IL82710A - 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it - Google Patents

3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it

Info

Publication number
IL82710A
IL82710A IL82710A IL8271087A IL82710A IL 82710 A IL82710 A IL 82710A IL 82710 A IL82710 A IL 82710A IL 8271087 A IL8271087 A IL 8271087A IL 82710 A IL82710 A IL 82710A
Authority
IL
Israel
Prior art keywords
dichlorophenyl
diamino
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL82710A
Other languages
English (en)
Other versions
IL82710A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL82710A0 publication Critical patent/IL82710A0/xx
Publication of IL82710A publication Critical patent/IL82710A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
IL82710A 1986-05-30 1987-05-29 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it IL82710A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868613183A GB8613183D0 (en) 1986-05-30 1986-05-30 Triazine salt

Publications (2)

Publication Number Publication Date
IL82710A0 IL82710A0 (en) 1987-11-30
IL82710A true IL82710A (en) 1992-01-15

Family

ID=10598692

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82710A IL82710A (en) 1986-05-30 1987-05-29 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it

Country Status (18)

Country Link
US (1) US4847249A (ja)
EP (1) EP0247892B1 (ja)
JP (1) JPH0751571B2 (ja)
KR (1) KR910002254B1 (ja)
AT (1) ATE62902T1 (ja)
AU (1) AU597982B2 (ja)
CA (1) CA1286670C (ja)
DE (1) DE3769516D1 (ja)
DK (1) DK166278C (ja)
ES (1) ES2021709B3 (ja)
FI (1) FI90770C (ja)
GB (1) GB8613183D0 (ja)
GR (1) GR3001942T3 (ja)
HU (1) HU196769B (ja)
IE (1) IE60626B1 (ja)
IL (1) IL82710A (ja)
NZ (1) NZ220497A (ja)
ZA (1) ZA873896B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
EP0522128B1 (en) * 1991-01-30 1996-01-17 The Wellcome Foundation Limited Water-dispersible tablets
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
JP3439211B2 (ja) * 1992-06-12 2003-08-25 ザ ウエルカム ファウンデーション リミテッド 薬物に対する依存性，耐性および感作の処置および予防における３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジン イセチオネートの使用
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2699078B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application de la lamotrigine dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700117B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
FR2702148B1 (fr) * 1993-03-05 1995-04-07 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement du neuro-sida.
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9306639D0 (en) * 1993-03-30 1993-05-26 Tocris Neuramin Limited Organic compounds
FR2702149B1 (fr) * 1993-06-03 1995-04-07 Rhone Poulenc Rorer Sa Application de la lamotrigine dans le traitement du neuro-sida.
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
AU1292400A (en) * 1998-12-14 2000-07-03 Sharad Kumar Vyas An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
AU763244B2 (en) * 2000-01-03 2003-07-17 Rpg Life Sciences Limited A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
IL134730A (en) * 2000-02-25 2003-10-31 Chemagis Ltd Process for preparing substituted benzoyl cyanide amidinohydrazones
EP1390355A4 (en) * 2001-02-27 2005-02-23 Teva Pharma NEW CRYSTALLINE FORMS OF LAMOTRIGIN AND METHOD FOR THE PRODUCTION THEREOF
US20050238724A1 (en) * 2002-04-23 2005-10-27 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing lamotrigine particles of defined morphology
HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
WO2009061513A1 (en) 2007-11-09 2009-05-14 Thar Pharmaceuticals Crystalline forms of lamotrigine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530999B2 (en) * 1979-06-01 1983-08-04 Wellcome Foundation Limited, The Substituted amino triazines and their use in treatment of cns disorders
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
DE3271930D1 (en) * 1982-05-03 1986-08-14 Richardson Vicks Ltd Pharmaceutical preparation for the topical treatment of acne
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds

Also Published As

Publication number Publication date
KR910002254B1 (ko) 1991-04-08
DK166278C (da) 1993-08-23
AU7368487A (en) 1987-12-03
JPS62289570A (ja) 1987-12-16
IE871415L (en) 1987-11-30
IL82710A0 (en) 1987-11-30
US4847249A (en) 1989-07-11
DE3769516D1 (de) 1991-05-29
ZA873896B (en) 1989-01-25
IE60626B1 (en) 1994-07-27
DK275987A (da) 1987-12-01
FI872406A (fi) 1987-12-01
DK166278B (da) 1993-03-29
HUT45978A (en) 1988-09-28
ES2021709B3 (es) 1991-11-16
EP0247892A1 (en) 1987-12-02
FI872406A0 (fi) 1987-05-29
JPH0751571B2 (ja) 1995-06-05
ATE62902T1 (de) 1991-05-15
EP0247892B1 (en) 1991-04-24
GB8613183D0 (en) 1986-07-02
HU196769B (en) 1989-01-30
AU597982B2 (en) 1990-06-14
FI90770B (fi) 1993-12-15
DK275987D0 (da) 1987-05-29
KR870011112A (ko) 1987-12-21
CA1286670C (en) 1991-07-23
NZ220497A (en) 1990-05-28
GR3001942T3 (en) 1992-11-23
FI90770C (fi) 1994-03-25

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Legal Events

Date Code Title Description
KB Patent renewed