IL81233A - Functionalized peptidyl aminodiols and-triols and pharmaceutical compositions comprising them - Google Patents

Functionalized peptidyl aminodiols and-triols and pharmaceutical compositions comprising them

Info

Publication number
IL81233A
IL81233A IL81233A IL8123387A IL81233A IL 81233 A IL81233 A IL 81233A IL 81233 A IL81233 A IL 81233A IL 8123387 A IL8123387 A IL 8123387A IL 81233 A IL81233 A IL 81233A
Authority
IL
Israel
Prior art keywords
aminodiols
peptidyl
triols
functionalized
pharmaceutical compositions
Prior art date
Application number
IL81233A
Other languages
English (en)
Other versions
IL81233A0 (en
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL81233A0 publication Critical patent/IL81233A0/xx
Priority to IL9197440A priority Critical patent/IL97440A0/xx
Publication of IL81233A publication Critical patent/IL81233A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL81233A 1986-01-16 1987-01-21 Functionalized peptidyl aminodiols and-triols and pharmaceutical compositions comprising them IL81233A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL9197440A IL97440A0 (en) 1986-01-16 1991-03-05 Intermediates useful for the preparation of functionalized peptidyl aminodiol and aminotriol renin inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871586A 1986-01-16 1986-01-16
US94356686A 1986-12-31 1986-12-31

Publications (2)

Publication Number Publication Date
IL81233A0 IL81233A0 (en) 1987-08-31
IL81233A true IL81233A (en) 1992-06-21

Family

ID=27124299

Family Applications (2)

Application Number Title Priority Date Filing Date
IL81233A IL81233A (en) 1986-01-16 1987-01-21 Functionalized peptidyl aminodiols and-triols and pharmaceutical compositions comprising them
IL9197440A IL97440A0 (en) 1986-01-16 1991-03-05 Intermediates useful for the preparation of functionalized peptidyl aminodiol and aminotriol renin inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL9197440A IL97440A0 (en) 1986-01-16 1991-03-05 Intermediates useful for the preparation of functionalized peptidyl aminodiol and aminotriol renin inhibitors

Country Status (6)

Country Link
EP (1) EP0230266A3 (ko)
KR (1) KR910002694B1 (ko)
AU (1) AU583971B2 (ko)
DK (1) DK20887A (ko)
IL (2) IL81233A (ko)
NZ (1) NZ218937A (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
US4977141A (en) * 1987-10-01 1990-12-11 G. D. Searle & Co. Peptidyl α-aminoacyl aminodiol carbamates as anti-hypertensive agents
CA1328333C (en) * 1988-03-04 1994-04-05 Quirico Branca Amino acid derivatives
US4994477A (en) * 1988-03-24 1991-02-19 Abbott Laboratories Heterocyclic renin inhibitors
US4977277A (en) * 1988-05-09 1990-12-11 Abbott Laboratories Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
FI893212A (fi) * 1988-07-01 1990-01-02 Searle & Co Antihypertensiva aminoalkylaminokarbo- nylaminodiolaminsyraderivat.
NO892727L (no) * 1988-07-01 1990-01-02 Searle & Co Eterholdige n-terminale aminodiolaminosyre derivater som anti-hypertensive midler.
EP0355331A3 (en) * 1988-07-01 1991-08-14 G.D. Searle & Co. Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents
US5059589A (en) * 1988-09-08 1991-10-22 Abbott Laboratories Glaucoma treatment
IL91780A (en) * 1988-10-04 1995-08-31 Abbott Lab History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5360791A (en) * 1988-11-24 1994-11-01 Hoechst Aktiengesellschaft Renin-inhibiting aminodiol derivatives
JPH04506808A (ja) * 1989-07-19 1992-11-26 ジ・アップジョン・カンパニー 転移状態擬態としてのジアミノグリコール類を含有するペプチド類
DK0410278T3 (da) * 1989-07-25 1994-05-24 Hoechst Ag Reninhæmmende aminooligohydroxyderivater
CA2023099A1 (en) * 1989-09-04 1991-03-05 Quirico Branca Amino acid derivatives
ATE135368T1 (de) * 1989-09-12 1996-03-15 Hoechst Ag Aminosäurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
EP0428849A3 (en) * 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
DK0435059T3 (da) * 1989-12-16 1998-07-27 Hoechst Ag Inhibitorer af retrovirale proteaser
TW198712B (ko) * 1991-04-17 1993-01-21 Hoffmann La Roche
US5258362A (en) * 1991-06-11 1993-11-02 Abbott Laboratories Renin inhibiting compounds
US6133296A (en) * 1996-05-10 2000-10-17 Bayer Aktiengesellschaft Substituted pyridyl keto enols

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
FI88400C (fi) * 1984-08-06 1993-05-10 Upjohn Co Foerfarande foer framstaellning av renin inhiberande peptider
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
AU6759887A (en) 1987-07-23
DK20887D0 (da) 1987-01-15
IL97440A0 (en) 1992-06-21
NZ218937A (en) 1990-03-27
EP0230266A2 (en) 1987-07-29
IL81233A0 (en) 1987-08-31
DK20887A (da) 1988-07-17
AU583971B2 (en) 1989-05-11
KR910002694B1 (ko) 1991-05-03
KR870007204A (ko) 1987-08-17
EP0230266A3 (en) 1990-01-17

Similar Documents

Publication Publication Date Title
IL81233A (en) Functionalized peptidyl aminodiols and-triols and pharmaceutical compositions comprising them
NZ222980A (en) 3-aryloxy-3-substituted propanamines and pharmaceutical compositions
NZ223096A (en) Peptidylaminodiols and pharmaceutical compositions
IL95351A0 (en) 17beta-acyl-4-aza-5alpha-androst-1-en-3-ones and pharmaceutical compositions containing them
NZ220880A (en) Di-tert-butyl-phenol derivatives and pharmaceutical compositions
IL82221A0 (en) Phenyl-piperazines and pharmaceutical compositions containing them
NZ222373A (en) Antihypertensive agents and pharmaceutical compositions containing nor-statine and cyclostatine
NZ222977A (en) Aminotetralins and pharmaceutical compositions; 8-substituted-2-aminotetralins and pharmaceutical compositions thereof
NZ218823A (en) Indole derivatives and pharmaceutical compositions thereof
NZ220353A (en) Pyrazoles and pharmaceutical compositions
NZ221996A (en) Imidazo-pyridine derivatives and pharmaceutical compositions
NZ220171A (en) Dihydro-benzopyran derivatives and pharmaceutical compositions
NZ223875A (en) 9-aminotetrahydroacridines and related homologues and pharmaceutical compositions
NZ220020A (en) 1-hydroxy-2-pyridones and pharmaceutical composition
NZ220441A (en) Unca-hydrazide-immunoglobulin (glyoprotein) conjugates and pharmaceutical composition
NZ221222A (en) Renin-inhibiting di and tripeptides and pharmaceutical compositions
IL78939A0 (en) N-substituted arylalkyl-and arylalkylene-aminoheterocyclics and pharmaceutical compositions containing them
NZ214821A (en) Spiro-dioxolanes, -dithiolanes and -oxothiolanes and pharmaceutical compositions
NZ233011A (en) Thieno-triazole-diazepine and pharmaceutical compositions
NZ217798A (en) N-substituted diphenylpiperidines and pharmaceutical compositions
NZ226450A (en) Crystalline-1-carbacephalosporin and pharmaceutical compositions
NZ218837A (en) Melphalan derivatives and pharmaceutical compositions
NZ215070A (en) Imidazole-indoles and pharmaceutical compositions
EP0257616A3 (en) Dihydropyridine derivates and pharmaceutical composition thereof
NZ223051A (en) Carbamoyloxylabdane derivatives and pharmaceutical compositions