IL70998A - Method of obtaining vincristine and its addition salts and products thus obtained - Google Patents
Method of obtaining vincristine and its addition salts and products thus obtainedInfo
- Publication number
- IL70998A IL70998A IL70998A IL7099884A IL70998A IL 70998 A IL70998 A IL 70998A IL 70998 A IL70998 A IL 70998A IL 7099884 A IL7099884 A IL 7099884A IL 70998 A IL70998 A IL 70998A
- Authority
- IL
- Israel
- Prior art keywords
- vincristine
- addition salts
- obtaining
- products
- vinblastine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229960004528 vincristine Drugs 0.000 title abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229960003048 vinblastine Drugs 0.000 abstract 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84640A LU84640A1 (fr) | 1983-02-10 | 1983-02-10 | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL70998A true IL70998A (en) | 1986-12-31 |
Family
ID=19730034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL70998A IL70998A (en) | 1983-02-10 | 1984-02-17 | Method of obtaining vincristine and its addition salts and products thus obtained |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0117861B1 (enExample) |
| JP (1) | JPS59152390A (enExample) |
| AT (1) | ATE31311T1 (enExample) |
| DE (1) | DE3468028D1 (enExample) |
| ES (1) | ES529562A0 (enExample) |
| HU (1) | HU189817B (enExample) |
| IL (1) | IL70998A (enExample) |
| LU (1) | LU84640A1 (enExample) |
| ZA (1) | ZA84963B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| FR2651348B1 (enExample) * | 1989-08-04 | 1993-01-22 | Adir | |
| CN101362771B (zh) * | 2008-09-26 | 2010-12-08 | 深圳万乐药业有限公司 | 高纯度硫酸长春新碱的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
| US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
-
1983
- 1983-02-10 LU LU84640A patent/LU84640A1/fr unknown
-
1984
- 1984-02-08 ES ES529562A patent/ES529562A0/es active Granted
- 1984-02-09 AT AT84870018T patent/ATE31311T1/de not_active IP Right Cessation
- 1984-02-09 EP EP84870018A patent/EP0117861B1/fr not_active Expired
- 1984-02-09 ZA ZA84963A patent/ZA84963B/xx unknown
- 1984-02-09 HU HU84526A patent/HU189817B/hu not_active IP Right Cessation
- 1984-02-09 DE DE8484870018T patent/DE3468028D1/de not_active Expired
- 1984-02-09 JP JP59022703A patent/JPS59152390A/ja active Granted
- 1984-02-17 IL IL70998A patent/IL70998A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8506033A1 (es) | 1985-07-01 |
| HU189817B (en) | 1986-08-28 |
| DE3468028D1 (en) | 1988-01-21 |
| LU84640A1 (fr) | 1984-11-08 |
| JPS59152390A (ja) | 1984-08-31 |
| ATE31311T1 (de) | 1987-12-15 |
| EP0117861B1 (fr) | 1987-12-09 |
| ES529562A0 (es) | 1985-07-01 |
| ZA84963B (en) | 1984-09-26 |
| JPH041758B2 (enExample) | 1992-01-14 |
| EP0117861A1 (fr) | 1984-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2964981D1 (en) | Continuous process for the recovery of polycarbonate from solutions of it, and polycarbonate powders thus obtained | |
| PT70128A (en) | Process for preparing 4,5-diaryl-2-nitroimidazoles having antiinflammatory activity | |
| YU43032B (en) | Process for obtaining 2,5-diketo-d-gluconic acid | |
| PT79683A (en) | Chemical process for preparing l 17392 (deglucoteicoplanin) and its salts | |
| IL70998A (en) | Method of obtaining vincristine and its addition salts and products thus obtained | |
| IL56946A0 (en) | Process for prparing 2,3,5,6,-tetrachloropyridine and pentachloropyridine | |
| ZA841146B (en) | Process for manufacturing detergent powder | |
| EG14602A (en) | Process for preparing of 1-benzoyl-3-(aryloxy or arylthiopyridinyl)urea compound | |
| EP0256590A3 (en) | Bimetallic catalyst | |
| IL57850A (en) | Process for recovering 2,3,5,6-tetrachloropyridine from mixtures of chlorinated pyridines | |
| DE3161632D1 (en) | Process for the preparation of opaque perylene-tetracarboxylic-bis-(3,5-dimethylphenyl imide) | |
| GB8623771D0 (en) | Chemical compounds | |
| GB8616074D0 (en) | Chemical process | |
| EG15938A (en) | Process for preparing p.chlorophenoxyacetyl-peronylpine-razine | |
| HU178105B (en) | Process for preparing 7beta-/halo-aryl /-malonamido/- 7alpha-methoxy-3-/ alkyl-tetrazol-5-yl- or -1,3,4-thiadiazol-2-yl /-thiomethyl/- 1-dethia-1-oxa-3-cephem-4-carboxylic acid derivatives | |
| PL253590A1 (en) | Method of obtaining novel 9-/1-or 3-monoacyloxy-or 1,3-diacyloxy-2-propoxymethyl/purines or their addition salts with acids | |
| Srinivasan | Oxidation/Corrosion of Surface-Modified Alloys | |
| Zaritskii et al. | The Corrosion of Carbon Steel in Aqueous, Acetone, and Aqueous-Acetone Solutions of Allyl Alcohol | |
| Fares et al. | Determination of the stability constants(log K) for Fe-fulvic acid and Fe-humic acid complexes by super (55) Fe super (3+). | |
| Vu et al. | Carburizing Ni--Mo Steels Prepared From Mixed Powders | |
| ES8404969A1 (es) | Un procedimiento para preparar acido-hidroxi-metilglutarico. | |
| YU40779B (en) | Process for, the oxidizing chemical decomposition of uranium or by means ofa carbanate solution | |
| Shishkin et al. | Influence of Means of Introducing Oxygen on the Emission Properties of Niobium | |
| Bates | Preparation of Tantalum Powder | |
| DE2966854D1 (en) | Process for recovering 2,3,5,6-tetrachloropyridine from mixtures of chlorinated pyridines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |