ES529562A0 - Procedimiento de obtencion de vincristina y de sus sales de adicion - Google Patents
Procedimiento de obtencion de vincristina y de sus sales de adicionInfo
- Publication number
- ES529562A0 ES529562A0 ES529562A ES529562A ES529562A0 ES 529562 A0 ES529562 A0 ES 529562A0 ES 529562 A ES529562 A ES 529562A ES 529562 A ES529562 A ES 529562A ES 529562 A0 ES529562 A0 ES 529562A0
- Authority
- ES
- Spain
- Prior art keywords
- vincristine
- procedure
- obtaining
- additional salts
- vinblastine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229960004528 vincristine Drugs 0.000 title abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229960003048 vinblastine Drugs 0.000 abstract 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84640A LU84640A1 (fr) | 1983-02-10 | 1983-02-10 | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8506033A1 ES8506033A1 (es) | 1985-07-01 |
| ES529562A0 true ES529562A0 (es) | 1985-07-01 |
Family
ID=19730034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529562A Granted ES529562A0 (es) | 1983-02-10 | 1984-02-08 | Procedimiento de obtencion de vincristina y de sus sales de adicion |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0117861B1 (enExample) |
| JP (1) | JPS59152390A (enExample) |
| AT (1) | ATE31311T1 (enExample) |
| DE (1) | DE3468028D1 (enExample) |
| ES (1) | ES529562A0 (enExample) |
| HU (1) | HU189817B (enExample) |
| IL (1) | IL70998A (enExample) |
| LU (1) | LU84640A1 (enExample) |
| ZA (1) | ZA84963B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| FR2651348B1 (enExample) * | 1989-08-04 | 1993-01-22 | Adir | |
| CN101362771B (zh) * | 2008-09-26 | 2010-12-08 | 深圳万乐药业有限公司 | 高纯度硫酸长春新碱的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
| HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
-
1983
- 1983-02-10 LU LU84640A patent/LU84640A1/fr unknown
-
1984
- 1984-02-08 ES ES529562A patent/ES529562A0/es active Granted
- 1984-02-09 AT AT84870018T patent/ATE31311T1/de not_active IP Right Cessation
- 1984-02-09 ZA ZA84963A patent/ZA84963B/xx unknown
- 1984-02-09 HU HU84526A patent/HU189817B/hu not_active IP Right Cessation
- 1984-02-09 JP JP59022703A patent/JPS59152390A/ja active Granted
- 1984-02-09 EP EP84870018A patent/EP0117861B1/fr not_active Expired
- 1984-02-09 DE DE8484870018T patent/DE3468028D1/de not_active Expired
- 1984-02-17 IL IL70998A patent/IL70998A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0117861B1 (fr) | 1987-12-09 |
| ZA84963B (en) | 1984-09-26 |
| ES8506033A1 (es) | 1985-07-01 |
| HU189817B (en) | 1986-08-28 |
| IL70998A (en) | 1986-12-31 |
| DE3468028D1 (en) | 1988-01-21 |
| JPS59152390A (ja) | 1984-08-31 |
| LU84640A1 (fr) | 1984-11-08 |
| JPH041758B2 (enExample) | 1992-01-14 |
| ATE31311T1 (de) | 1987-12-15 |
| EP0117861A1 (fr) | 1984-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2964981D1 (en) | Continuous process for the recovery of polycarbonate from solutions of it, and polycarbonate powders thus obtained | |
| NZ189726A (en) | Chemical process on surface of rotating body | |
| DE3071055D1 (en) | Process for prolonging the validity of the memory working zone of a data carrier | |
| IT8424192A0 (it) | Metodo per la produzione continuadi dispersioni di pigmento di ftalocianina in un solvente organico. | |
| DE3367594D1 (en) | Potassium reagent and process for the determination of potassium ions | |
| GB1549447A (en) | Process for the production of 4,4'-isopropylidene-bis-(2,6-dibromophenol) | |
| NL188930C (nl) | Werkwijze voor het stabiliseren van bekledingen van metaaloxydedeeltjes op buisvormige substraten van koolstof. | |
| OA05784A (fr) | Procédé d'oxydation de solutions d'un sel ferreux. | |
| LU80576A1 (fr) | Procede de preparation de nouvelles indolo(2,3-a)quinolizidines | |
| YU40717B (en) | Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids | |
| DE3468028D1 (en) | Process for the preparation of vincristine | |
| NL7708910A (nl) | Werkwijze voor de bereiding van nieuwe gesubstitueerde 2-fenylaminoimidazoline-(2) verbindingen alsmede zuuradditiezouten daarvan. | |
| IT8048317A0 (it) | Procedimento per stabilizzare un bagno acquoso per elettrodeposizione e bagno cosi' ottenuto | |
| PT75708A (en) | Improved process for the preparation of supported reverse osmosis membranes | |
| IT7927484A0 (it) | Procedimento per l'incisione disuperfici di pezzi mediante attacco chimico. | |
| YU41614B (en) | Process for obtaining recemic or opticaly active 11-disubstituted actahydroindolo (2,3,-a) quinalizine | |
| IL57850A (en) | Process for recovering 2,3,5,6-tetrachloropyridine from mixtures of chlorinated pyridines | |
| BE877937A (fr) | Compose chimique heterocyclique 6-phenyl 1,2,3, oxadiazolo-(4,5d) pyridazine-7(6h)-one et procede pour sa prepaeation | |
| Korol et al. | Investigation of Magnetoresistors Based on CdxHg 1-xTe in the Temperature Range 4. 2-300 K | |
| PT66491A (en) | Process for preparing novel derivatives of 6-(m-aminophenyl)-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole(m-aminotetramisole | |
| BAHNSEN | FERTIGUNG EINER ELEKTRONISCHEN...(FABRICATION OF AN ELECTRONIC PLUG-IN CONNECTION) | |
| PL199356A1 (pl) | Sposob ustawiania magnetycznego zespolu odchylajacego w kineskopie,kineskop posiadajacy zespol odchylajacy albo punkty odniesienia umieszczone wedlug tego sposobu-oraz zespol odchylajacy zaopatrzony w punkty odniesienia umieszczone wedlug tego sposobu | |
| Petrov et al. | The principle of developing systems(minimum dispersion error for goal seeking linear dynamic systems) | |
| YU161079A (en) | Process for poducing suspensions or solutions of cyanuric chloride in organic solvents | |
| IT7826429A0 (it) | Processo per la produzione di polifosfato d'ammonio ed apparecchiatura relativa. |