ATE31311T1 - Verfahren zur herstellung von vincristin. - Google Patents
Verfahren zur herstellung von vincristin.Info
- Publication number
- ATE31311T1 ATE31311T1 AT84870018T AT84870018T ATE31311T1 AT E31311 T1 ATE31311 T1 AT E31311T1 AT 84870018 T AT84870018 T AT 84870018T AT 84870018 T AT84870018 T AT 84870018T AT E31311 T1 ATE31311 T1 AT E31311T1
- Authority
- AT
- Austria
- Prior art keywords
- vinblastine
- degrees
- permanganate
- vincristin
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229960004528 vincristine Drugs 0.000 title abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229960003048 vinblastine Drugs 0.000 abstract 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84640A LU84640A1 (fr) | 1983-02-10 | 1983-02-10 | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
| EP84870018A EP0117861B1 (fr) | 1983-02-10 | 1984-02-09 | Procédé d'obtention de la vincristine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE31311T1 true ATE31311T1 (de) | 1987-12-15 |
Family
ID=19730034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84870018T ATE31311T1 (de) | 1983-02-10 | 1984-02-09 | Verfahren zur herstellung von vincristin. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0117861B1 (enExample) |
| JP (1) | JPS59152390A (enExample) |
| AT (1) | ATE31311T1 (enExample) |
| DE (1) | DE3468028D1 (enExample) |
| ES (1) | ES8506033A1 (enExample) |
| HU (1) | HU189817B (enExample) |
| IL (1) | IL70998A (enExample) |
| LU (1) | LU84640A1 (enExample) |
| ZA (1) | ZA84963B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| FR2651348B1 (enExample) * | 1989-08-04 | 1993-01-22 | Adir | |
| CN101362771B (zh) * | 2008-09-26 | 2010-12-08 | 深圳万乐药业有限公司 | 高纯度硫酸长春新碱的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
| HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
-
1983
- 1983-02-10 LU LU84640A patent/LU84640A1/fr unknown
-
1984
- 1984-02-08 ES ES529562A patent/ES8506033A1/es not_active Expired
- 1984-02-09 ZA ZA84963A patent/ZA84963B/xx unknown
- 1984-02-09 AT AT84870018T patent/ATE31311T1/de not_active IP Right Cessation
- 1984-02-09 DE DE8484870018T patent/DE3468028D1/de not_active Expired
- 1984-02-09 HU HU84526A patent/HU189817B/hu not_active IP Right Cessation
- 1984-02-09 EP EP84870018A patent/EP0117861B1/fr not_active Expired
- 1984-02-09 JP JP59022703A patent/JPS59152390A/ja active Granted
- 1984-02-17 IL IL70998A patent/IL70998A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU189817B (en) | 1986-08-28 |
| ES529562A0 (es) | 1985-07-01 |
| EP0117861A1 (fr) | 1984-09-05 |
| ES8506033A1 (es) | 1985-07-01 |
| JPS59152390A (ja) | 1984-08-31 |
| LU84640A1 (fr) | 1984-11-08 |
| DE3468028D1 (en) | 1988-01-21 |
| ZA84963B (en) | 1984-09-26 |
| IL70998A (en) | 1986-12-31 |
| EP0117861B1 (fr) | 1987-12-09 |
| JPH041758B2 (enExample) | 1992-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT377522B (de) | Verfahren zur herstellung von furo-(3,4-c)pyridinderivaten | |
| DE3788939D1 (de) | Verfahren zur Herstellung von Uretdionringen enthaltenden Polyurethanen. | |
| ATE23533T1 (de) | Kaliumreagens und verfahren zur bestimmung von kaliumionen. | |
| ATE46503T1 (de) | Verfahren zur herstellung von perhalogenomethansulfinsaeuren und -sulfonsaeuren und deren salze. | |
| AT362477B (de) | Verfahren zur herstellung von (u,pu)02-misch- kristallen | |
| AT359064B (de) | Verfahren zur herstellung von neuen 1h- -pyrazolo (3,4-b)-pyridinen und deren saeure- additionssalzen | |
| ATE31311T1 (de) | Verfahren zur herstellung von vincristin. | |
| PT75708B (en) | Improved process for the preparation of supported reverse osmosis membranes | |
| DD132664A5 (de) | Verfahren zur herstellung von 1,2,4-triazol-(5)-yl(thio)-phosphat | |
| ATE20536T1 (de) | Verfahren zur herstellung von detergenspulver. | |
| ATA585977A (de) | Verfahren zur herstellung von 5-amino-1,2,3- thiadiazol | |
| AT364842B (de) | Verfahren zur herstellung von neuen octahydroindolo(2,3-a)chinolizinen, deren saeureadditionssalzen und optischen antipoden | |
| ATA345079A (de) | Verfahren zur herstellung von 4'-substituierten 2,4-dichlor-alpha-(imidazol-n-ylmethyl)dibenzyl[thern und von deren salzen | |
| ATA112277A (de) | Verfahren zur herstellung von neuen 2,9-dioxa- tricyclo (4,3,1,03,7) decanen und deren salzen | |
| AT377586B (de) | Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen | |
| ATE14211T1 (de) | Verfahren zur herstellung von ceriumcarboxylaten. | |
| PT70874A (de) | Verfahren zur herstellung von einem enthaltenden 6-substituierte 3-dimethylamino-4-methyl-1,2,4-triazin-5(4h)-one herbizidemittel | |
| DD130248A5 (de) | Verfahren zur herstellung von thiophosphorsaeure-0,0-dialkylesterchlorid | |
| AT385655B (de) | Verfahren zur herstellung von therapeutisch anwendbaren loesungen - insbesondere von solchen zur parenteralen verabreichung -, welche als wirkstoff einen polynuklearen, gemischten eisen/ iii/-komplex enthalten | |
| DD129445A6 (de) | Verfahren zur herstellung von 1-sulfonyl-5(6)-subst.-benzimidazolen | |
| GB8623771D0 (en) | Chemical compounds | |
| ATE23527T1 (de) | Verfahren zur herstellung von p.chlorophenoxyacetyl-piperonylpiperazin. | |
| AT373593B (de) | Verfahren zur herstellung von 1,2,3-thiadiazol-5- yl-harnstoffen | |
| PT65684A (de) | Verfahren zur herstellung von stabilisierten,reines theophyllin rein waessrigem,neutralem milieu enthaltenden loesungen | |
| GB1546068A (en) | Process for recovering 6-(d(-)-alpha-amino-alpha-(p-hydroxyphenyl)-acetamido)penicillanic acid or 7-(d-(-)-alpha-amino-alpha-(p-hydroxyphenyl)-acetamido)-3-(1,2,3-triazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acid from an acid solution thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |