IL70998A - Method of obtaining vincristine and its addition salts and products thus obtained - Google Patents

Method of obtaining vincristine and its addition salts and products thus obtained

Info

Publication number
IL70998A
IL70998A IL70998A IL7099884A IL70998A IL 70998 A IL70998 A IL 70998A IL 70998 A IL70998 A IL 70998A IL 7099884 A IL7099884 A IL 7099884A IL 70998 A IL70998 A IL 70998A
Authority
IL
Israel
Prior art keywords
vincristine
addition salts
obtaining
products
vinblastine
Prior art date
Application number
IL70998A
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of IL70998A publication Critical patent/IL70998A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

1. Process for the preparation of vincristine or its addition salts from vinblastine characterized in that vinblastine is treated with permanganate ion in acid medium in an inert solvent consisting of toluene or dichloromethane, the permanganate ion being solubilized by action of a macrocyclic polyether on the potassium permanganate or in the state of a quaternary ammonium salt soluble in the said inert solvant, and in that the reaction medium is maintained at a temperature of between -40 degrees C and -75 degrees C.
IL70998A 1983-02-10 1984-02-17 Method of obtaining vincristine and its addition salts and products thus obtained IL70998A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU84640A LU84640A1 (en) 1983-02-10 1983-02-10 NEW PROCESS FOR OBTAINING VINCRISTINE AND VINCRISTINE SULFATE

Publications (1)

Publication Number Publication Date
IL70998A true IL70998A (en) 1986-12-31

Family

ID=19730034

Family Applications (1)

Application Number Title Priority Date Filing Date
IL70998A IL70998A (en) 1983-02-10 1984-02-17 Method of obtaining vincristine and its addition salts and products thus obtained

Country Status (9)

Country Link
EP (1) EP0117861B1 (en)
JP (1) JPS59152390A (en)
AT (1) ATE31311T1 (en)
DE (1) DE3468028D1 (en)
ES (1) ES8506033A1 (en)
HU (1) HU189817B (en)
IL (1) IL70998A (en)
LU (1) LU84640A1 (en)
ZA (1) ZA84963B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582651B1 (en) * 1985-06-03 1987-08-28 Pf Medicament PROCESS FOR THE PREPARATION OF VINCRISTINE
FR2651348B1 (en) * 1989-08-04 1993-01-22 Adir
CN101362771B (en) * 2008-09-26 2010-12-08 深圳万乐药业有限公司 Method for preparing high purity vincristine sulfate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
US4303584A (en) * 1980-04-02 1981-12-01 Eli Lilly And Company Method of preparing vincristine
HU183385B (en) * 1980-04-02 1984-04-28 Lilly Co Eli Process for preparing vinca dimer derivatives

Also Published As

Publication number Publication date
EP0117861A1 (en) 1984-09-05
LU84640A1 (en) 1984-11-08
JPH041758B2 (en) 1992-01-14
ZA84963B (en) 1984-09-26
HU189817B (en) 1986-08-28
EP0117861B1 (en) 1987-12-09
JPS59152390A (en) 1984-08-31
ES529562A0 (en) 1985-07-01
ATE31311T1 (en) 1987-12-15
ES8506033A1 (en) 1985-07-01
DE3468028D1 (en) 1988-01-21

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