IL62847A - Pharmaceutical composition for the treatment of juvenile diabetes mellitus comprising insulin and l-carnitine and/or an l-acylcarnitine - Google Patents
Pharmaceutical composition for the treatment of juvenile diabetes mellitus comprising insulin and l-carnitine and/or an l-acylcarnitineInfo
- Publication number
- IL62847A IL62847A IL62847A IL6284781A IL62847A IL 62847 A IL62847 A IL 62847A IL 62847 A IL62847 A IL 62847A IL 6284781 A IL6284781 A IL 6284781A IL 62847 A IL62847 A IL 62847A
- Authority
- IL
- Israel
- Prior art keywords
- acylcarnitine
- carnitine
- insulin
- treatment
- pharmaceutical composition
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 229960001518 levocarnitine Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48692/80A IT1133010B (it) | 1980-05-15 | 1980-05-15 | Metodo terapuetico per il trattamento del diabete mellito a insorgenza giovanile e composizione farmaceutica per tale metodo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL62847A0 IL62847A0 (en) | 1981-07-31 |
| IL62847A true IL62847A (en) | 1985-01-31 |
Family
ID=11268073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL62847A IL62847A (en) | 1980-05-15 | 1981-05-12 | Pharmaceutical composition for the treatment of juvenile diabetes mellitus comprising insulin and l-carnitine and/or an l-acylcarnitine |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4362719A (it) |
| JP (1) | JPS579721A (it) |
| AU (1) | AU540859B2 (it) |
| BE (1) | BE888797A (it) |
| CA (1) | CA1173749A (it) |
| CH (1) | CH654208A5 (it) |
| DE (1) | DE3119460A1 (it) |
| FR (1) | FR2482588B1 (it) |
| GB (1) | GB2075838B (it) |
| IE (1) | IE51224B1 (it) |
| IL (1) | IL62847A (it) |
| IT (1) | IT1133010B (it) |
| NL (1) | NL8102384A (it) |
| SE (1) | SE8103003L (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1157238B (it) * | 1982-10-29 | 1987-02-11 | Sigma Tau Ind Farmaceuti | Impiego di 1-carnitina per migliorare i paramenti biochimici e comportamentali dell'eta' senile |
| IT1237343B (it) * | 1984-03-28 | 1993-05-31 | Francia Farma | Dicloridrato di acetildicarnitina, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono |
| US4537772A (en) * | 1984-05-02 | 1985-08-27 | Merck & Co., Inc. | Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines |
| US5545412A (en) * | 1985-01-07 | 1996-08-13 | Syntex (U.S.A.) Inc. | N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4731360A (en) * | 1985-08-16 | 1988-03-15 | Merck & Co., Inc. | Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments |
| DE3635864A1 (de) * | 1986-06-26 | 1988-05-05 | Gerhard Gergely | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
| US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| US5321009A (en) * | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
| US5420108A (en) * | 1992-09-14 | 1995-05-30 | Shohet; Isaac H. | Method of controlling diabetes mellitus |
| US6046232A (en) * | 1997-10-17 | 2000-04-04 | Centaur Pharmaceuticals, Inc. | α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same |
| IT1306178B1 (it) * | 1999-07-27 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina e dei suoi alcanoil derivati per la preparazionedi un medicamento utile nel trattamento del paziente affetto da |
| US6835754B2 (en) * | 2001-01-08 | 2004-12-28 | Renovis, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| ITRM20040327A1 (it) * | 2004-07-01 | 2004-10-01 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici. |
| RU2324479C2 (ru) * | 2006-07-11 | 2008-05-20 | Денис Владимирович Сидько | Способ комплексной инфузионной терапии у больных с гипергликемической кетоацидотической диабетической комой |
| EP2162127A1 (en) * | 2007-05-24 | 2010-03-17 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Composition useful for the prevention of adverse effect due to the use of ppar-gamma agonists |
| CN107121540B (zh) * | 2016-02-24 | 2020-06-12 | 中国科学院上海营养与健康研究所 | 酰基肉碱谱或其检测试剂在2型糖尿病发病风险预测中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624887A (en) * | 1970-03-02 | 1971-12-07 | Bunker Ramo | Pin and socket removal tool |
| US3810994A (en) * | 1972-06-01 | 1974-05-14 | Ethyl Corp | Method and composition for treating obesity |
| JPS5058213A (it) * | 1973-09-26 | 1975-05-21 | ||
| FR2414914A1 (fr) * | 1978-01-18 | 1979-08-17 | Sigma Tau Ind Farmaceuti | Utilisations therapeutiques nouvelles de l'acetyl-1-carnitine et d'autres derives acyles de la 1-carnitine |
-
1980
- 1980-05-15 IT IT48692/80A patent/IT1133010B/it active
-
1981
- 1981-05-07 IE IE1011/81A patent/IE51224B1/en not_active IP Right Cessation
- 1981-05-12 AU AU70486/81A patent/AU540859B2/en not_active Expired
- 1981-05-12 GB GB8114456A patent/GB2075838B/en not_active Expired
- 1981-05-12 IL IL62847A patent/IL62847A/xx not_active IP Right Cessation
- 1981-05-13 SE SE8103003A patent/SE8103003L/ unknown
- 1981-05-13 CA CA000377523A patent/CA1173749A/en not_active Expired
- 1981-05-14 BE BE0/204781A patent/BE888797A/fr not_active IP Right Cessation
- 1981-05-14 NL NL8102384A patent/NL8102384A/nl not_active Application Discontinuation
- 1981-05-14 CH CH3155/81A patent/CH654208A5/it not_active IP Right Cessation
- 1981-05-15 JP JP7407781A patent/JPS579721A/ja active Pending
- 1981-05-15 FR FR8109780A patent/FR2482588B1/fr not_active Expired
- 1981-05-15 DE DE19813119460 patent/DE3119460A1/de not_active Ceased
- 1981-05-15 US US06/264,044 patent/US4362719A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2075838A (en) | 1981-11-25 |
| SE8103003L (sv) | 1981-11-16 |
| AU7048681A (en) | 1981-11-26 |
| IT1133010B (it) | 1986-07-09 |
| JPS579721A (en) | 1982-01-19 |
| AU540859B2 (en) | 1984-12-06 |
| GB2075838B (en) | 1984-05-10 |
| FR2482588B1 (fr) | 1986-03-07 |
| IE51224B1 (en) | 1986-11-12 |
| IE811011L (en) | 1981-11-15 |
| IL62847A0 (en) | 1981-07-31 |
| US4362719A (en) | 1982-12-07 |
| FR2482588A1 (fr) | 1981-11-20 |
| CA1173749A (en) | 1984-09-04 |
| CH654208A5 (it) | 1986-02-14 |
| DE3119460A1 (de) | 1982-03-04 |
| NL8102384A (nl) | 1981-12-01 |
| BE888797A (fr) | 1981-08-28 |
| IT8048692A0 (it) | 1980-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| EXP | Patent expired |