IL62327A0 - Method and vector organism for controlled accumulation of cloned heterologous gene products in bacillus subtilis - Google Patents
Method and vector organism for controlled accumulation of cloned heterologous gene products in bacillus subtilisInfo
- Publication number
- IL62327A0 IL62327A0 IL62327A IL6232781A IL62327A0 IL 62327 A0 IL62327 A0 IL 62327A0 IL 62327 A IL62327 A IL 62327A IL 6232781 A IL6232781 A IL 6232781A IL 62327 A0 IL62327 A0 IL 62327A0
- Authority
- IL
- Israel
- Prior art keywords
- bacillus subtilis
- gene products
- heterologous gene
- controlled accumulation
- cloned heterologous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12853780A | 1980-03-10 | 1980-03-10 | |
US22180080A | 1980-12-31 | 1980-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL62327A0 true IL62327A0 (en) | 1981-05-20 |
Family
ID=26826682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL62327A IL62327A0 (en) | 1980-03-10 | 1981-03-09 | Method and vector organism for controlled accumulation of cloned heterologous gene products in bacillus subtilis |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0036259B1 (xx) |
AU (1) | AU545912B2 (xx) |
CA (1) | CA1182408A (xx) |
DE (1) | DE3177067D1 (xx) |
DK (1) | DK172711B1 (xx) |
ES (2) | ES8307895A1 (xx) |
FI (1) | FI810722L (xx) |
IL (1) | IL62327A0 (xx) |
NO (1) | NO810803L (xx) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3005843A1 (de) * | 1980-02-16 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
FI64813C (fi) * | 1980-12-31 | 1984-01-10 | Ilkka Antero Palva | Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer |
PT74811B (en) * | 1981-04-29 | 1983-10-26 | Biogen Nv | Bacillus cloning vectors recombinant dna molecules bacillus hosts transformed with them and methods for expressing foreign dna sequences and producing polypeptides coded thereby |
US4460689A (en) * | 1982-04-15 | 1984-07-17 | Merck & Co., Inc. | DNA Cloning vector TG1, derivatives, and processes of making |
US4508826A (en) * | 1982-04-15 | 1985-04-02 | Merck & Co., Inc. | Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1 |
FR2537602B2 (fr) * | 1982-09-24 | 1986-10-24 | Centre Nat Rech Scient | Nouvel adn recombinant perfectionne utile dans la preparation d'a-amylase par bacillus subtilis |
FR2533583A1 (fr) * | 1982-09-24 | 1984-03-30 | Centre Nat Rech Scient | Nouvel adn recombinant utile dans la preparation d'a-amylase |
US4559300A (en) * | 1983-01-18 | 1985-12-17 | Eli Lilly And Company | Method for using an homologous bacillus promoter and associated natural or modified ribosome binding site-containing DNA sequence in streptomyces |
US4783405A (en) * | 1983-01-18 | 1988-11-08 | Eli Lilly And Company | Recombinant DNA expression vectors useful in bacillus and other host cells |
US4585739A (en) * | 1983-03-07 | 1986-04-29 | E. I. Du Pont De Nemours And Company | Plasmid for foreign gene expression in B. subtilis |
DK138984A (da) * | 1983-03-08 | 1984-09-09 | Rikagaku Kenkyusho | Plasmid, fremgangsmaade til fremstilling heraf, mikroorganismer indeholdende samme samt fremgangsmaade til dyrkning af mikroorganismen |
NZ207842A (en) * | 1983-04-25 | 1988-02-12 | Chiron Corp | Production of human insulin-like growth factor (igf) using cdna |
US4663280A (en) * | 1983-05-19 | 1987-05-05 | Public Health Research Institute Of The City Of New York | Expression and secretion vectors and method of constructing vectors |
US4912046A (en) * | 1983-06-27 | 1990-03-27 | Genentech, Inc. | Portable inducible control system |
US5624829A (en) * | 1984-07-03 | 1997-04-29 | Gist-Brocades, B.V. | Transformed industrial bacillus strains and methods for making and using them |
AU570709B2 (en) * | 1983-07-06 | 1988-03-24 | Dsm N.V. | Cloning and expression in industrial species |
JPS60137291A (ja) * | 1983-12-26 | 1985-07-20 | Takeda Chem Ind Ltd | 発現ベクター |
WO1986000619A1 (en) * | 1984-07-13 | 1986-01-30 | Chiron Corporation | Prepro insulin-like growth factors i and ii |
JPH062074B2 (ja) * | 1984-07-27 | 1994-01-12 | 國男 山根 | オリゴペプチドの製法 |
SE8403929L (sv) * | 1984-07-31 | 1986-02-21 | Sten Gatenbeck | Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas |
US5032510A (en) * | 1984-09-26 | 1991-07-16 | Eli Lilly And Company | Method for expression and secretion in bacillus |
IT1177378B (it) * | 1984-12-11 | 1987-08-26 | Anic Spa | Vettore plasmidico psm112 ad espressione in bacillus subtilis |
IT1208514B (it) * | 1985-03-19 | 1989-07-10 | Eniricerche Spa | Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis. |
EP0221923A4 (en) * | 1985-03-29 | 1990-03-22 | Bioteknika International | SECRETION VECTOR. |
IT1186750B (it) * | 1985-07-10 | 1987-12-16 | Eniricerche Spa | Vettore di clonaggio,molecole di dna ricombinante,ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni |
US4977089A (en) * | 1987-01-30 | 1990-12-11 | Eli Lilly And Company | Vector comprising signal peptide-encoding DNA for use in Bacillus and other microorganisms |
EP0785273A1 (en) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Paired basic amino acid converting enzyme and DNA sequence encoding it |
GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
AU1979599A (en) | 1998-01-14 | 1999-08-02 | Chiron S.P.A. | (neisseria meningitidis) antigens |
GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
EP1093517B1 (en) | 1998-05-01 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
NZ581940A (en) | 1999-04-30 | 2011-07-29 | Novartis Vaccines & Diagnostic | Conserved neisserial antigens |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
PT2275553E (pt) | 1999-10-29 | 2015-09-18 | Glaxosmithkline Biolog Sa | Péptidos antigénicos de neisseria |
BR0107679A (pt) | 2000-01-17 | 2004-07-06 | Chiron Spa | Vacina de vesìcula de membrana externa (omv) compreendendo proteìnas de membrana externa do grupo sérico b de neisseria meningitidis |
JP4254931B1 (ja) | 2000-10-27 | 2009-04-15 | カイロン ソチエタ ア レスポンサビリタ リミタータ | A群連鎖球菌およびb群連鎖球菌由来の核酸およびタンパク質 |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
US20050232936A1 (en) | 2001-07-27 | 2005-10-20 | Chiron Corporation | Meningococcus adhesins nada, app and orf 40 |
EP2335724A1 (en) | 2001-12-12 | 2011-06-22 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation against chlamydia trachomatis |
EP1513945A4 (en) | 2002-05-24 | 2008-12-24 | Restoragen Inc | PROCESS FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES |
WO2003099854A2 (en) | 2002-05-24 | 2003-12-04 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
DK2279746T3 (da) | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
CA2546319A1 (en) | 2003-11-21 | 2005-07-28 | Nps Allelix Corp. | Production of glucagon like peptide 2 and analogs |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
EP2886551A3 (en) | 2008-02-21 | 2015-09-23 | Novartis AG | Meningococcal fhbp polypeptides |
ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
CN104650241A (zh) | 2009-08-27 | 2015-05-27 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
MX2012004850A (es) | 2009-10-27 | 2012-05-22 | Novartis Ag | Polipeptidos fhbp meningococicos modificados. |
FR2954349A1 (fr) | 2009-12-22 | 2011-06-24 | Agronomique Inst Nat Rech | Sulfatase modifiant selectivement les glycosaminoglycanes |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
GR71912B (xx) * | 1978-08-11 | 1983-08-16 | Univ California | |
FR2442271A1 (fr) * | 1978-11-27 | 1980-06-20 | Pasteur Institut | Vecteur permettant l'insertion d'un gene procaryote ou eucaryote, et l'excretion de la proteine exprimee |
GB2048894A (en) * | 1979-05-11 | 1980-12-17 | Gist Brocades Nv | Plasmid |
GR70279B (xx) * | 1979-09-12 | 1982-09-03 | Univ California | |
IL61982A (en) * | 1980-02-15 | 1984-01-31 | Cpc International Inc | Genetically engineered microorganisms for massive production of amyloytic enzymes and process for preparing same using the corresponding recombinant dnas containing amylase coding genes |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
-
1981
- 1981-02-27 AU AU67902/81A patent/AU545912B2/en not_active Expired
- 1981-03-02 EP EP81300858A patent/EP0036259B1/en not_active Expired
- 1981-03-02 DE DE8181300858T patent/DE3177067D1/de not_active Expired
- 1981-03-09 IL IL62327A patent/IL62327A0/xx unknown
- 1981-03-09 ES ES500201A patent/ES8307895A1/es not_active Expired
- 1981-03-09 FI FI810722A patent/FI810722L/fi not_active Application Discontinuation
- 1981-03-10 DK DK198101095A patent/DK172711B1/da not_active IP Right Cessation
- 1981-03-10 NO NO810803A patent/NO810803L/no unknown
- 1981-03-10 CA CA000372633A patent/CA1182408A/en not_active Expired
-
1982
- 1982-03-01 ES ES510011A patent/ES8306796A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES510011A0 (es) | 1983-06-01 |
DK172711B1 (da) | 1999-06-07 |
FI810722L (fi) | 1981-09-11 |
ES8306796A1 (es) | 1983-06-01 |
ES500201A0 (es) | 1983-07-01 |
CA1182408A (en) | 1985-02-12 |
DK109581A (da) | 1981-09-11 |
ES8307895A1 (es) | 1983-07-01 |
AU6790281A (en) | 1981-09-17 |
AU545912B2 (en) | 1985-08-08 |
EP0036259B1 (en) | 1989-06-14 |
NO810803L (no) | 1981-09-11 |
EP0036259A3 (en) | 1982-06-09 |
DE3177067D1 (en) | 1989-07-20 |
EP0036259A2 (en) | 1981-09-23 |
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