IL58299A - Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use - Google Patents
Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal useInfo
- Publication number
- IL58299A IL58299A IL58299A IL5829979A IL58299A IL 58299 A IL58299 A IL 58299A IL 58299 A IL58299 A IL 58299A IL 5829979 A IL5829979 A IL 5829979A IL 58299 A IL58299 A IL 58299A
- Authority
- IL
- Israel
- Prior art keywords
- fluorine
- production
- medicinal use
- dihydropyridine derivatives
- dihydropyridine
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- 239000011737 fluorine Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782841667 DE2841667A1 (de) | 1978-09-25 | 1978-09-25 | Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL58299A0 IL58299A0 (en) | 1979-12-30 |
| IL58299A true IL58299A (en) | 1983-03-31 |
Family
ID=6050376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL58299A IL58299A (en) | 1978-09-25 | 1979-09-21 | Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4256749A (ru) |
| EP (1) | EP0009206B1 (ru) |
| JP (2) | JPS6016934B2 (ru) |
| AT (1) | ATE290T1 (ru) |
| CA (1) | CA1130291A (ru) |
| DE (2) | DE2841667A1 (ru) |
| DK (1) | DK157013C (ru) |
| ES (1) | ES484397A1 (ru) |
| FI (1) | FI70887C (ru) |
| GR (1) | GR74127B (ru) |
| HK (1) | HK15184A (ru) |
| HU (1) | HU178449B (ru) |
| IE (1) | IE49462B1 (ru) |
| IL (1) | IL58299A (ru) |
| SG (1) | SG38783G (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508446B1 (fr) * | 1981-06-25 | 1986-05-02 | Rhone Poulenc Agrochimie | Herbicides a fonctions amide et ester derives de la pyridine ainsi que leur procede de preparation et leur application |
| DE3130041A1 (de) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| JPS5897332U (ja) * | 1981-12-24 | 1983-07-02 | 株式会社昭和製作所 | 油圧緩衝器の減衰力調整機構 |
| JPS5897333U (ja) * | 1981-12-24 | 1983-07-02 | 株式会社昭和製作所 | 油圧緩衝器の減衰力調整機構 |
| DE3312283A1 (de) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern |
| DE3316510A1 (de) * | 1983-05-06 | 1984-11-08 | Bayer Ag | Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen |
| US4677101A (en) * | 1983-09-26 | 1987-06-30 | Merck & Co., Inc. | Substituted dihydroazepines useful as calcium channel blockers |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| EP0169009A3 (en) * | 1984-07-17 | 1988-08-31 | FISONS plc | Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals |
| DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS62292757A (ja) * | 1986-06-12 | 1987-12-19 | Taisho Pharmaceut Co Ltd | １，４−ジヒドロピリジン誘導体 |
| US4868181A (en) * | 1986-08-04 | 1989-09-19 | E. I. Du Pont De Nemours And Company | 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
| JPS63160458U (ru) * | 1987-04-09 | 1988-10-20 | ||
| US5177211A (en) * | 1988-01-21 | 1993-01-05 | Alter, S.A. | 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity |
| US5216172A (en) * | 1988-02-24 | 1993-06-01 | Ajinomoto Co., Inc. | 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells |
| EP0330470A3 (en) * | 1988-02-24 | 1992-01-02 | Ajinomoto Co., Inc. | 1,4-dihydropyridine derivatives useful against tumour cells |
| DE3833893A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte |
| JP3040364U (ja) * | 1996-07-23 | 1997-08-19 | 清秀 中川 | 芳香含有物質の詰め替え可能な枕 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
| GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1978
- 1978-09-25 DE DE19782841667 patent/DE2841667A1/de not_active Withdrawn
-
1979
- 1979-09-10 US US06/074,048 patent/US4256749A/en not_active Expired - Lifetime
- 1979-09-12 AT AT79103411T patent/ATE290T1/de active
- 1979-09-12 DE DE7979103411T patent/DE2961012D1/de not_active Expired
- 1979-09-12 EP EP79103411A patent/EP0009206B1/de not_active Expired
- 1979-09-21 JP JP54120911A patent/JPS6016934B2/ja not_active Expired
- 1979-09-21 IL IL58299A patent/IL58299A/xx unknown
- 1979-09-21 FI FI792939A patent/FI70887C/fi not_active IP Right Cessation
- 1979-09-21 CA CA336,100A patent/CA1130291A/en not_active Expired
- 1979-09-24 HU HU79BA3852A patent/HU178449B/hu not_active IP Right Cessation
- 1979-09-24 ES ES484397A patent/ES484397A1/es not_active Expired
- 1979-09-24 GR GR60102A patent/GR74127B/el unknown
- 1979-09-24 IE IE1802/79A patent/IE49462B1/en unknown
- 1979-09-24 DK DK399079A patent/DK157013C/da not_active IP Right Cessation
-
1983
- 1983-07-02 SG SG387/83A patent/SG38783G/en unknown
-
1984
- 1984-02-23 HK HK151/84A patent/HK15184A/xx unknown
- 1984-07-27 JP JP59155722A patent/JPS6069018A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0009206A3 (en) | 1980-04-16 |
| IE49462B1 (en) | 1985-10-16 |
| DE2841667A1 (de) | 1980-04-10 |
| EP0009206A2 (de) | 1980-04-02 |
| HK15184A (en) | 1984-03-02 |
| CA1130291A (en) | 1982-08-24 |
| IL58299A0 (en) | 1979-12-30 |
| US4256749A (en) | 1981-03-17 |
| ATE290T1 (de) | 1981-10-15 |
| FI792939A (fi) | 1980-03-26 |
| DK399079A (da) | 1980-03-26 |
| JPS6016934B2 (ja) | 1985-04-30 |
| HU178449B (en) | 1982-05-28 |
| DK157013C (da) | 1990-03-26 |
| GR74127B (ru) | 1984-06-06 |
| JPS5547657A (en) | 1980-04-04 |
| DE2961012D1 (en) | 1981-12-24 |
| JPS6217972B2 (ru) | 1987-04-21 |
| FI70887C (fi) | 1986-10-27 |
| SG38783G (en) | 1984-07-27 |
| DK157013B (da) | 1989-10-30 |
| FI70887B (fi) | 1986-07-18 |
| ES484397A1 (es) | 1980-05-16 |
| JPS6069018A (ja) | 1985-04-19 |
| EP0009206B1 (de) | 1981-10-14 |
| IE791802L (en) | 1980-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2963183D1 (en) | 1,4-dihydropyridine compounds, their preparation, pharmaceutical compositions containing said compounds and preparation of these compositions | |
| PH15562A (en) | New hydroxyethyl-azole compounds,their production and their medicinal use | |
| IL58299A (en) | Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use | |
| PT77898B (en) | Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation | |
| ZA796356B (en) | New hydroxypropyl-triazole compounds, their production and their medicinal use | |
| DE2961609D1 (en) | Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation | |
| DE3064109D1 (en) | Pseudotrisaccharides, their preparation and use as medicaments | |
| PT71308A (en) | Process for the preparation of new 3,4,5-trihidrocy-piperidine derivatives with pharmaceutical and/or veterinary effect | |
| IL58774A0 (en) | Fluorenyl-azolylmethyl-carbinol compounds,their production and pharmaceutical compositions containing them | |
| JPS5536484A (en) | Novel 1*44dihydropyridazinee33carboxylic acid derivative | |
| JPS5536485A (en) | Nnaminoo3*4*55trihydoxypiperidines*their manufacture and use as drug |