IL55862A0 - Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them - Google Patents

Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them

Info

Publication number
IL55862A0
IL55862A0 IL55862A IL5586278A IL55862A0 IL 55862 A0 IL55862 A0 IL 55862A0 IL 55862 A IL55862 A IL 55862A IL 5586278 A IL5586278 A IL 5586278A IL 55862 A0 IL55862 A0 IL 55862A0
Authority
IL
Israel
Prior art keywords
oxygenated
dioxo
novel
preparation
pregnane derivatives
Prior art date
Application number
IL55862A
Other languages
English (en)
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of IL55862A0 publication Critical patent/IL55862A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0089—Sulfur-containing hetero ring containing sulfur and oxygen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
IL55862A 1977-11-08 1978-11-03 Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them IL55862A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/849,563 US4201778A (en) 1977-11-08 1977-11-08 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates

Publications (1)

Publication Number Publication Date
IL55862A0 true IL55862A0 (en) 1979-01-31

Family

ID=25306004

Family Applications (1)

Application Number Title Priority Date Filing Date
IL55862A IL55862A0 (en) 1977-11-08 1978-11-03 Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them

Country Status (9)

Country Link
US (1) US4201778A (de)
EP (1) EP0001864A1 (de)
JP (1) JPS5473765A (de)
AU (1) AU4127478A (de)
DK (1) DK489378A (de)
FI (1) FI783340A (de)
IL (1) IL55862A0 (de)
IT (1) IT1099828B (de)
ZA (1) ZA786054B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
US4808610A (en) * 1986-10-02 1989-02-28 Schering Corporation Mometasone furoate anti-inflammatory cream composition using hexylene glycol
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (de) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-Informatiksystem
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10231979B2 (en) * 2015-08-07 2019-03-19 Indiana University Research And Technology Corporation Modulation of inflammation using progesterone metabolites

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1184505A (fr) * 1955-06-07 1959-07-22 Scherico Ltd Procédé de préparation de composés stéroïdes de la série du prégnane
US3079301A (en) * 1956-04-25 1963-02-26 Schering Corp 9alpha-halo-1, 4, 6-pregnatrienes and therapeutic compositions containing same
US2816902A (en) * 1957-01-14 1957-12-17 Schering Corp Hydroxylated steroids
US2937975A (en) * 1958-08-18 1960-05-24 Pfizer & Co C Steroid halohydrins and process therefor
US2887499A (en) * 1958-11-13 1959-05-19 Schering Corp Hydroxylated steroid intermediates and methods for their manufacture
US3032565A (en) * 1960-08-24 1962-05-01 Searle & Co Process for the manufacture of 6-alkoxy-and 6-keto steroids and compounds obtained thereby
US3071580A (en) * 1961-04-28 1963-01-01 American Cyanamid Co 6beta-hydroxy-16alpha, 17alpha-alkylidendioxy-11-oxygenated pregnenes
US3131181A (en) * 1961-05-29 1964-04-28 American Cyanamid Co Method of preparing 6-hydroxy pregnenes and pregnadienes and products resulting therefrom
US3629303A (en) * 1969-06-09 1971-12-21 Schering Corp 6-alkoxy - 16 - alkylidene - 17alpha - lower alkanoyloxy-21-desoxy - 4 6 - pregnadienes methods for their manufacture and intermediates produced thereby
SE418294B (sv) * 1974-03-27 1981-05-18 Plurichemie Anstalt Sett att framstella en 16alfa- eller 16beta-9alfa-klor eller -fluorsteroidester
US4076708A (en) * 1976-12-22 1978-02-28 Schering Corporation Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby

Also Published As

Publication number Publication date
EP0001864A1 (de) 1979-05-16
AU4127478A (en) 1979-05-17
DK489378A (da) 1979-05-09
JPS5473765A (en) 1979-06-13
IT1099828B (it) 1985-09-28
US4201778A (en) 1980-05-06
ZA786054B (en) 1979-10-31
IT7829133A0 (it) 1978-10-26
FI783340A (fi) 1979-05-09

Similar Documents

Publication Publication Date Title
DE2860900D1 (en) Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
IL55109A (en) 1-acyl-2-cyanoaziridines,process for their preparation and pharmaceutical compositions containing them
DE2860637D1 (en) Dihydrouracils, process for their preparation and pharmaceuticals containing them
DE2861361D1 (en) 1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing them
IL55862A0 (en) Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them
DE2861482D1 (en) Pyrazino-benzoxazepine and -benzthiazepine derivatives, processes for their production and pharmaceutical compositions containing them
IL54069A (en) 14,15-dihydro-20,21-dinoreburnamenin-14-ol derivatives,process for preparing them and pharmaceutical compositions containing them
DE2860928D1 (en) 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them
IL60408A (en) Sulfur-containing isoquinoline derivatives,process for the preparation thereof and pharmaceutical compositions containing them
IL55427A0 (en) 2-hydrazonopropionic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL52148A (en) Substituted 1-phenoxy-2-hydroxy-3-aminopropanes,process for preparing same and pharmaceutical compositions containing them
DE2861767D1 (en) Cephalosprin derivatives, process for their preparation and pharmaceutical compositions containing them
IL53685A (en) N2-arylsulfonyl-l-argininamides and the pharmaceutical salts thereof,process for their preparation and pharmaceutical compositions containing them
DE2860067D1 (en) Aminophenoxymethyl-2-morpholine derivatives, the preparation thereof and pharmaceuticals containing them
DE2860614D1 (en) N-benzylpyrimidinyl-amidines, process for their preparation and medicines containing them
DE3061160D1 (en) 15-methanesulfonamidoprostaglandin derivatives, pharmaceutical compositions thereof and process therefor
ZA784123B (en) Imidazo-isoquinoline-diones,process for preparation and pharmaceutical compositions thereof
ZA782432B (en) 2-benzyl-perhydroazepines,process for their preparation and pharmaceutical compositions containing them
IL55139A (en) Substituted 2-cyclopropyl-chromones,process for their preparation and pharmaceutical compositions containing them
IL52207A (en) Substituted 2-vinyl-chromones, process for their preparation and pharmaceutical compositions containing them
IL54736A0 (en) 4-hydroxythiazolidine-2-thione derivatives, a process for their preparation and pharmaceutical compositions containing them
IL54718A (en) 17beta-hydroxy delta4-androsten-3-ones,process for their manufacture and pharmaceutical compositions containing them
GB2004885B (en) Indolopyrones process for the preparation thereof and pharmaceutical compositions containing them
ZA785599B (en) New piperazinopyrrolobenzodiazepines,process for their manufacture and pharmaceutical preparations containing them
ZA786963B (en) 5,6-dihydro-prostacyclin derivatives and process for their preparation