DK489378A - 6-oxygenerede-3,20-dioxopregnanderivater samt fremgangsmaade til fremstilling der af og farmaceutiske kompositioner indeholdende disse - Google Patents

6-oxygenerede-3,20-dioxopregnanderivater samt fremgangsmaade til fremstilling der af og farmaceutiske kompositioner indeholdende disse

Info

Publication number
DK489378A
DK489378A DK489378A DK489378A DK489378A DK 489378 A DK489378 A DK 489378A DK 489378 A DK489378 A DK 489378A DK 489378 A DK489378 A DK 489378A DK 489378 A DK489378 A DK 489378A
Authority
DK
Denmark
Prior art keywords
dioxopregnan
oxygenated
procedures
derivatives
preparation
Prior art date
Application number
DK489378A
Other languages
English (en)
Inventor
R W Draper
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of DK489378A publication Critical patent/DK489378A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0068Nitrogen and oxygen at position 16(17)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073Sulfur-containing hetero ring
    • C07J71/0089Sulfur-containing hetero ring containing sulfur and oxygen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DK489378A 1977-11-08 1978-11-02 6-oxygenerede-3,20-dioxopregnanderivater samt fremgangsmaade til fremstilling der af og farmaceutiske kompositioner indeholdende disse DK489378A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/849,563 US4201778A (en) 1977-11-08 1977-11-08 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates

Publications (1)

Publication Number Publication Date
DK489378A true DK489378A (da) 1979-05-09

Family

ID=25306004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK489378A DK489378A (da) 1977-11-08 1978-11-02 6-oxygenerede-3,20-dioxopregnanderivater samt fremgangsmaade til fremstilling der af og farmaceutiske kompositioner indeholdende disse

Country Status (9)

Country Link
US (1) US4201778A (da)
EP (1) EP0001864A1 (da)
JP (1) JPS5473765A (da)
AU (1) AU4127478A (da)
DK (1) DK489378A (da)
FI (1) FI783340A (da)
IL (1) IL55862A0 (da)
IT (1) IT1099828B (da)
ZA (1) ZA786054B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
US4808610A (en) * 1986-10-02 1989-02-28 Schering Corporation Mometasone furoate anti-inflammatory cream composition using hexylene glycol
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10231979B2 (en) * 2015-08-07 2019-03-19 Indiana University Research And Technology Corporation Modulation of inflammation using progesterone metabolites

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1184505A (fr) * 1955-06-07 1959-07-22 Scherico Ltd Procédé de préparation de composés stéroïdes de la série du prégnane
US3079301A (en) * 1956-04-25 1963-02-26 Schering Corp 9alpha-halo-1, 4, 6-pregnatrienes and therapeutic compositions containing same
US2816902A (en) * 1957-01-14 1957-12-17 Schering Corp Hydroxylated steroids
US2937975A (en) * 1958-08-18 1960-05-24 Pfizer & Co C Steroid halohydrins and process therefor
US2887499A (en) * 1958-11-13 1959-05-19 Schering Corp Hydroxylated steroid intermediates and methods for their manufacture
US3032565A (en) * 1960-08-24 1962-05-01 Searle & Co Process for the manufacture of 6-alkoxy-and 6-keto steroids and compounds obtained thereby
US3071580A (en) * 1961-04-28 1963-01-01 American Cyanamid Co 6beta-hydroxy-16alpha, 17alpha-alkylidendioxy-11-oxygenated pregnenes
US3131181A (en) * 1961-05-29 1964-04-28 American Cyanamid Co Method of preparing 6-hydroxy pregnenes and pregnadienes and products resulting therefrom
US3629303A (en) * 1969-06-09 1971-12-21 Schering Corp 6-alkoxy - 16 - alkylidene - 17alpha - lower alkanoyloxy-21-desoxy - 4 6 - pregnadienes methods for their manufacture and intermediates produced thereby
DE2512915A1 (de) * 1974-03-27 1975-10-09 Plurichemie Anstalt 16-methyl-9 alpha-halogen-steroide ester, aether und verfahren zu ihrer herstellung
US4076708A (en) * 1976-12-22 1978-02-28 Schering Corporation Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby

Also Published As

Publication number Publication date
FI783340A (fi) 1979-05-09
JPS5473765A (en) 1979-06-13
IL55862A0 (en) 1979-01-31
ZA786054B (en) 1979-10-31
IT1099828B (it) 1985-09-28
IT7829133A0 (it) 1978-10-26
AU4127478A (en) 1979-05-17
EP0001864A1 (en) 1979-05-16
US4201778A (en) 1980-05-06

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