ZA786054B - Novel 6-oxy-genated-3,20-dioxo-pregnane-derivatives,process for the preparation thereof,and pharmaceutical compositions containing them - Google Patents

Novel 6-oxy-genated-3,20-dioxo-pregnane-derivatives,process for the preparation thereof,and pharmaceutical compositions containing them

Info

Publication number
ZA786054B
ZA786054B ZA00786054A ZA786054A ZA786054B ZA 786054 B ZA786054 B ZA 786054B ZA 00786054 A ZA00786054 A ZA 00786054A ZA 786054 A ZA786054 A ZA 786054A ZA 786054 B ZA786054 B ZA 786054B
Authority
ZA
South Africa
Prior art keywords
genated
pregnane
dioxo
oxy
derivatives
Prior art date
Application number
ZA00786054A
Other languages
English (en)
Inventor
R Draper
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Priority to ES474745A priority Critical patent/ES474745A1/es
Priority to ES480141A priority patent/ES480141A1/es
Priority to ES480140A priority patent/ES480140A1/es
Publication of ZA786054B publication Critical patent/ZA786054B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0089—Sulfur-containing hetero ring containing sulfur and oxygen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
ZA00786054A 1977-11-08 1978-10-26 Novel 6-oxy-genated-3,20-dioxo-pregnane-derivatives,process for the preparation thereof,and pharmaceutical compositions containing them ZA786054B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES474745A ES474745A1 (es) 1977-11-08 1978-11-02 Procedimiento para la preparacion de derivados 6-oxigena- dos-3,20-dioxopregnano
ES480141A ES480141A1 (es) 1978-10-26 1979-05-02 Procedimiento para la preparacion de derivados 6-oxigenados-3, 20-dioxo-pregnano.
ES480140A ES480140A1 (es) 1977-11-08 1979-05-02 Procedimiento para preparacion de derivados de 3,6,20-trio- xo-pregnano.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/849,563 US4201778A (en) 1977-11-08 1977-11-08 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates

Publications (1)

Publication Number Publication Date
ZA786054B true ZA786054B (en) 1979-10-31

Family

ID=25306004

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00786054A ZA786054B (en) 1977-11-08 1978-10-26 Novel 6-oxy-genated-3,20-dioxo-pregnane-derivatives,process for the preparation thereof,and pharmaceutical compositions containing them

Country Status (9)

Country Link
US (1) US4201778A (xx)
EP (1) EP0001864A1 (xx)
JP (1) JPS5473765A (xx)
AU (1) AU4127478A (xx)
DK (1) DK489378A (xx)
FI (1) FI783340A (xx)
IL (1) IL55862A0 (xx)
IT (1) IT1099828B (xx)
ZA (1) ZA786054B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572589B2 (en) 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
US4808610A (en) * 1986-10-02 1989-02-28 Schering Corporation Mometasone furoate anti-inflammatory cream composition using hexylene glycol
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10231979B2 (en) * 2015-08-07 2019-03-19 Indiana University Research And Technology Corporation Modulation of inflammation using progesterone metabolites

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1184505A (fr) * 1955-06-07 1959-07-22 Scherico Ltd Procédé de préparation de composés stéroïdes de la série du prégnane
US3079301A (en) * 1956-04-25 1963-02-26 Schering Corp 9alpha-halo-1, 4, 6-pregnatrienes and therapeutic compositions containing same
US2816902A (en) * 1957-01-14 1957-12-17 Schering Corp Hydroxylated steroids
US2937975A (en) * 1958-08-18 1960-05-24 Pfizer & Co C Steroid halohydrins and process therefor
US2887499A (en) * 1958-11-13 1959-05-19 Schering Corp Hydroxylated steroid intermediates and methods for their manufacture
US3032565A (en) * 1960-08-24 1962-05-01 Searle & Co Process for the manufacture of 6-alkoxy-and 6-keto steroids and compounds obtained thereby
US3071580A (en) * 1961-04-28 1963-01-01 American Cyanamid Co 6beta-hydroxy-16alpha, 17alpha-alkylidendioxy-11-oxygenated pregnenes
US3131181A (en) * 1961-05-29 1964-04-28 American Cyanamid Co Method of preparing 6-hydroxy pregnenes and pregnadienes and products resulting therefrom
US3629303A (en) * 1969-06-09 1971-12-21 Schering Corp 6-alkoxy - 16 - alkylidene - 17alpha - lower alkanoyloxy-21-desoxy - 4 6 - pregnadienes methods for their manufacture and intermediates produced thereby
SE418294B (sv) * 1974-03-27 1981-05-18 Plurichemie Anstalt Sett att framstella en 16alfa- eller 16beta-9alfa-klor eller -fluorsteroidester
US4076708A (en) * 1976-12-22 1978-02-28 Schering Corporation Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby

Also Published As

Publication number Publication date
FI783340A (fi) 1979-05-09
JPS5473765A (en) 1979-06-13
AU4127478A (en) 1979-05-17
EP0001864A1 (en) 1979-05-16
IT1099828B (it) 1985-09-28
IT7829133A0 (it) 1978-10-26
DK489378A (da) 1979-05-09
IL55862A0 (en) 1979-01-31
US4201778A (en) 1980-05-06

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