IL48514A - Hexapeptide intermediate for the preparation of the lh-and fsh-releasing hormone - Google Patents
Hexapeptide intermediate for the preparation of the lh-and fsh-releasing hormoneInfo
- Publication number
- IL48514A IL48514A IL48514A IL4851473A IL48514A IL 48514 A IL48514 A IL 48514A IL 48514 A IL48514 A IL 48514A IL 4851473 A IL4851473 A IL 4851473A IL 48514 A IL48514 A IL 48514A
- Authority
- IL
- Israel
- Prior art keywords
- ester
- isolating
- treating
- mixture
- solution
- Prior art date
Links
- 108700012941 GNRH1 Proteins 0.000 title 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 9
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- -1 aralkyl ester Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000012442 inert solvent Substances 0.000 claims 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 5
- 239000011707 mineral Substances 0.000 claims 5
- 229910000510 noble metal Inorganic materials 0.000 claims 3
- 150000007530 organic bases Chemical class 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 150000008282 halocarbons Chemical class 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 150000004292 cyclic ethers Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00226508A US3835108A (en) | 1972-02-15 | 1972-02-15 | Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor |
| US24346572A | 1972-04-12 | 1972-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL48514A true IL48514A (en) | 1976-08-31 |
Family
ID=26920599
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL48514A IL48514A (en) | 1972-02-15 | 1973-01-17 | Hexapeptide intermediate for the preparation of the lh-and fsh-releasing hormone |
| IL41313A IL41313A (en) | 1972-02-15 | 1973-01-17 | Preparation of the lh-and fsh-releasing hormone and compositions containing it |
| IL48514A IL48514A0 (en) | 1972-02-15 | 1975-11-21 | Hexapeptide intermediate for the preparation of the lh-and fsh-releasing hormone |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41313A IL41313A (en) | 1972-02-15 | 1973-01-17 | Preparation of the lh-and fsh-releasing hormone and compositions containing it |
| IL48514A IL48514A0 (en) | 1972-02-15 | 1975-11-21 | Hexapeptide intermediate for the preparation of the lh-and fsh-releasing hormone |
Country Status (9)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE454879B (sv) * | 1982-06-29 | 1988-06-06 | Astra Laekemedel Ab | Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS528831B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-10-04 | 1977-03-11 |
-
1973
- 1973-01-17 NZ NZ169577A patent/NZ169577A/xx unknown
- 1973-01-17 IL IL48514A patent/IL48514A/en unknown
- 1973-01-17 IL IL41313A patent/IL41313A/en unknown
- 1973-02-13 DE DE2307010A patent/DE2307010C2/de not_active Expired
- 1973-02-14 GB GB3217475A patent/GB1425513A/en not_active Expired
- 1973-02-14 CH CH210773A patent/CH589608A5/xx not_active IP Right Cessation
- 1973-02-14 SE SE7302099A patent/SE403772B/xx unknown
- 1973-02-14 GB GB3217675A patent/GB1425512A/en not_active Expired
- 1973-02-14 GB GB718073A patent/GB1425511A/en not_active Expired
- 1973-02-14 FR FR7305151A patent/FR2181730B1/fr not_active Expired
- 1973-02-15 CA CA163,972A patent/CA1025441A/en not_active Expired
- 1973-02-15 JP JP1884473A patent/JPS5729462B2/ja not_active Expired
-
1975
- 1975-11-21 IL IL48514A patent/IL48514A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL41313A0 (en) | 1973-03-30 |
| DE2307010C2 (de) | 1986-08-21 |
| GB1425513A (en) | 1976-02-18 |
| GB1425512A (en) | 1976-02-18 |
| JPS5729462B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-06-23 |
| SE403772B (sv) | 1978-09-04 |
| CH589608A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-07-15 |
| FR2181730A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-12-07 |
| GB1425511A (en) | 1976-02-18 |
| FR2181730B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-07-15 |
| IL48514A0 (en) | 1976-01-30 |
| DE2307010A1 (de) | 1973-08-23 |
| IL41313A (en) | 1976-08-31 |
| NZ169577A (en) | 1984-09-28 |
| CA1025441A (en) | 1978-01-31 |
| JPS4886868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-11-15 |
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