IL45807A - תולדות של א7 - מתילאסטר - 4 - אנ - א3, ב71 - מדיאולים - Google Patents
תולדות של א7 - מתילאסטר - 4 - אנ - א3, ב71 - מדיאוליםInfo
- Publication number
- IL45807A IL45807A IL45807A IL4580774A IL45807A IL 45807 A IL45807 A IL 45807A IL 45807 A IL45807 A IL 45807A IL 4580774 A IL4580774 A IL 4580774A IL 45807 A IL45807 A IL 45807A
- Authority
- IL
- Israel
- Prior art keywords
- ene
- methylestr
- methy
- diol
- hydroxy
- Prior art date
Links
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- -1 2-tetrahydropyranyl Chemical group 0.000 claims description 21
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- 210000004877 mucosa Anatomy 0.000 description 1
- NPAGDVCDWIYMMC-IZPLOLCNSA-N nandrolone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 NPAGDVCDWIYMMC-IZPLOLCNSA-N 0.000 description 1
- 229960004719 nandrolone Drugs 0.000 description 1
- KPMKEVXVVHNIEY-RITPCOANSA-N norcamphor Chemical compound C1C[C@@H]2C(=O)C[C@H]1C2 KPMKEVXVVHNIEY-RITPCOANSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 150000007530 organic bases Chemical group 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 238000006053 organic reaction Methods 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000028742 placenta development Effects 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000035752 proliferative phase Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- PMXCMJLOPOFPBT-HNNXBMFYSA-N purvalanol A Chemical compound C=12N=CN(C(C)C)C2=NC(N[C@@H](CO)C(C)C)=NC=1NC1=CC=CC(Cl)=C1 PMXCMJLOPOFPBT-HNNXBMFYSA-N 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 238000011916 stereoselective reduction Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000011121 vaginal smear Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US411791A US3928398A (en) | 1973-11-01 | 1973-11-01 | Derivatives of 7{60 -methylestr-4-en-3{60 ,17{62 -diol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL45807A0 IL45807A0 (en) | 1974-12-31 |
| IL45807A true IL45807A (he) | 1977-10-31 |
Family
ID=23630345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL45807A IL45807A (he) | 1973-11-01 | 1974-10-07 | תולדות של א7 - מתילאסטר - 4 - אנ - א3, ב71 - מדיאולים |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3928398A (he) |
| JP (1) | JPS5071666A (he) |
| CA (1) | CA1020544A (he) |
| CH (1) | CH614721A5 (he) |
| DE (1) | DE2450036A1 (he) |
| DK (1) | DK137762B (he) |
| FR (1) | FR2249675B1 (he) |
| GB (1) | GB1438889A (he) |
| IL (1) | IL45807A (he) |
| NL (1) | NL7413751A (he) |
| SE (1) | SE416053B (he) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4073899A (en) * | 1974-09-16 | 1978-02-14 | Richardson-Merrell, Inc. | Method of terminating pregnancy |
| JPS589574B2 (ja) * | 1978-12-18 | 1983-02-22 | ティーディーケイ株式会社 | 自動巻線機のからげ装置 |
| MX9301121A (es) | 1992-03-02 | 1993-09-01 | Schering Ag | Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina. |
| US7704983B1 (en) | 1992-03-02 | 2010-04-27 | Eastern Virginia Medical School | Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception |
| US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
| US5516769A (en) * | 1993-02-19 | 1996-05-14 | The Medical College Of Hampton Roads | Method of inhibiting fertilization |
| US5468736A (en) * | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
| DE4344463A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Kombinationsprodukt zur Kontrazeption |
| PL356465A1 (en) * | 2002-10-04 | 2004-04-05 | ANPHARM Przedsiębiorstwo Farmaceutyczne S.A. | METHOD OF MANUFACTURE OF 17beta-HYDROXY-7alpha-METHYL-19-NOR-17alpha-PREGN-5(10)-ENE-20-YNE-3-ONE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262949A (en) * | 1956-11-13 | 1966-07-26 | Syntex Corp | 7-methyl androstane compounds |
| DE1250819B (de) * | 1962-11-23 | 1967-09-28 | Ciba Aktiengesellschaft, Basel (Schweiz) | Verfahren zur Herstellung von 3-Hydroxy - (bzw. -Acyloxy)-7a-alkyl-19-nor-4androstenen |
| BE642575A (he) * | 1963-01-16 | |||
| US3384543A (en) * | 1965-04-07 | 1968-05-21 | Upjohn Co | 7alpha-methyl-5-androstanes |
| US3846456A (en) * | 1965-04-07 | 1974-11-05 | Upjohn Co | Organic compounds |
| US3423404A (en) * | 1965-10-21 | 1969-01-21 | Searle & Co | (optionally 17-alkylated) estra-4,9(10)-diene - 3alpha/3beta,17beta - diols and esters corresponding |
-
1973
- 1973-11-01 US US411791A patent/US3928398A/en not_active Expired - Lifetime
-
1974
- 1974-09-23 CA CA209,767A patent/CA1020544A/en not_active Expired
- 1974-10-07 IL IL45807A patent/IL45807A/he unknown
- 1974-10-21 NL NL7413751A patent/NL7413751A/xx not_active Application Discontinuation
- 1974-10-22 DE DE19742450036 patent/DE2450036A1/de not_active Withdrawn
- 1974-10-28 CH CH1441074A patent/CH614721A5/xx not_active IP Right Cessation
- 1974-10-29 JP JP49123987A patent/JPS5071666A/ja active Pending
- 1974-10-30 SE SE7413684A patent/SE416053B/xx unknown
- 1974-10-31 GB GB4726674A patent/GB1438889A/en not_active Expired
- 1974-10-31 DK DK568674AA patent/DK137762B/da unknown
- 1974-10-31 FR FR7436464A patent/FR2249675B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1020544A (en) | 1977-11-08 |
| CH614721A5 (he) | 1979-12-14 |
| IL45807A0 (en) | 1974-12-31 |
| DE2450036A1 (de) | 1975-05-07 |
| FR2249675A1 (he) | 1975-05-30 |
| US3928398A (en) | 1975-12-23 |
| NL7413751A (nl) | 1975-05-06 |
| JPS5071666A (he) | 1975-06-13 |
| DK137762B (da) | 1978-05-01 |
| AU7369074A (en) | 1976-04-01 |
| DK568674A (he) | 1975-06-23 |
| GB1438889A (en) | 1976-06-09 |
| FR2249675B1 (he) | 1977-11-04 |
| SE416053B (sv) | 1980-11-24 |
| DK137762C (he) | 1978-11-06 |
| SE7413684L (he) | 1975-05-02 |
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