IL44622A - Single - sodium citrate crystals Monohydrate in the form of a prism and their preparation - Google Patents
Single - sodium citrate crystals Monohydrate in the form of a prism and their preparationInfo
- Publication number
- IL44622A IL44622A IL44622A IL4462274A IL44622A IL 44622 A IL44622 A IL 44622A IL 44622 A IL44622 A IL 44622A IL 4462274 A IL4462274 A IL 4462274A IL 44622 A IL44622 A IL 44622A
- Authority
- IL
- Israel
- Prior art keywords
- crystals
- monosodium
- monosodium citrate
- weak
- citrate
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title claims description 142
- IGHGOYDCVRUTSU-UHFFFAOYSA-M sodium;2-hydroxypropane-1,2,3-tricarboxylic acid;hydroxide Chemical compound [OH-].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O IGHGOYDCVRUTSU-UHFFFAOYSA-M 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 3
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 85
- 235000018342 monosodium citrate Nutrition 0.000 claims description 85
- 239000002524 monosodium citrate Substances 0.000 claims description 85
- 239000000243 solution Substances 0.000 claims description 49
- 238000002425 crystallisation Methods 0.000 claims description 45
- 230000008025 crystallization Effects 0.000 claims description 44
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 claims description 34
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 25
- 239000007864 aqueous solution Substances 0.000 claims description 20
- 238000002441 X-ray diffraction Methods 0.000 claims description 6
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 42
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 235000010633 broth Nutrition 0.000 description 14
- 239000012452 mother liquor Substances 0.000 description 11
- 238000001914 filtration Methods 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 238000001000 micrograph Methods 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 4
- 239000001354 calcium citrate Substances 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 235000013337 tricalcium citrate Nutrition 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 238000007738 vacuum evaporation Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229940038773 trisodium citrate Drugs 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000186249 Corynebacterium sp. Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000000909 electrodialysis Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000010956 selective crystallization Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4789073A JPS5724334B2 (it) | 1973-04-26 | 1973-04-26 | |
| JP13711273A JPS5724773B2 (it) | 1973-12-07 | 1973-12-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44622A0 IL44622A0 (en) | 1974-06-30 |
| IL44622A true IL44622A (en) | 1977-06-30 |
Family
ID=26388097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44622A IL44622A (en) | 1973-04-26 | 1974-04-12 | Single - sodium citrate crystals Monohydrate in the form of a prism and their preparation |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3925465A (it) |
| AR (1) | AR207952A1 (it) |
| AU (1) | AU484484B2 (it) |
| BE (1) | BE814178A (it) |
| BR (1) | BR7403333D0 (it) |
| CA (1) | CA1029394A (it) |
| DE (1) | DE2419622A1 (it) |
| FR (1) | FR2227258B1 (it) |
| GB (1) | GB1425437A (it) |
| HK (1) | HK15379A (it) |
| IE (1) | IE39376B1 (it) |
| IL (1) | IL44622A (it) |
| IN (1) | IN139392B (it) |
| IT (1) | IT1020587B (it) |
| MY (1) | MY7900158A (it) |
| NL (1) | NL178683C (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4014930A (en) * | 1974-05-10 | 1977-03-29 | Monsanto Company | Carboxy methoxy malonate |
| US4014929A (en) * | 1975-11-17 | 1977-03-29 | Monsanto Company | Ether carboxylate monohydrate |
| US5965028A (en) * | 1994-09-12 | 1999-10-12 | Reilly Industries, Inc. | Process for treating a liquid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4942556B1 (it) * | 1967-06-07 | 1974-11-15 | ||
| JPS5128709B1 (it) * | 1967-12-13 | 1976-08-20 | ||
| JPS496117B1 (it) * | 1969-01-22 | 1974-02-12 | ||
| JPS496118B1 (it) * | 1969-01-30 | 1974-02-12 | ||
| JPS4720395B1 (it) * | 1969-06-25 | 1972-06-09 |
-
1974
- 1974-01-01 AR AR253459A patent/AR207952A1/es active
- 1974-04-12 IL IL44622A patent/IL44622A/en unknown
- 1974-04-22 IE IE862/74A patent/IE39376B1/xx unknown
- 1974-04-24 AU AU68229/74A patent/AU484484B2/en not_active Expired
- 1974-04-24 DE DE2419622A patent/DE2419622A1/de not_active Withdrawn
- 1974-04-24 IT IT5/74A patent/IT1020587B/it active
- 1974-04-24 BR BR3333/74A patent/BR7403333D0/pt unknown
- 1974-04-25 FR FR7414481A patent/FR2227258B1/fr not_active Expired
- 1974-04-25 CA CA198,123A patent/CA1029394A/en not_active Expired
- 1974-04-25 US US464614A patent/US3925465A/en not_active Expired - Lifetime
- 1974-04-25 IN IN942/CAL/74A patent/IN139392B/en unknown
- 1974-04-25 BE BE143604A patent/BE814178A/xx not_active IP Right Cessation
- 1974-04-25 GB GB1813774A patent/GB1425437A/en not_active Expired
- 1974-04-26 NL NLAANVRAGE7405716,A patent/NL178683C/xx not_active IP Right Cessation
-
1979
- 1979-03-22 HK HK153/79A patent/HK15379A/xx unknown
- 1979-12-30 MY MY158/79A patent/MY7900158A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE39376L (en) | 1974-10-26 |
| NL178683C (nl) | 1986-05-01 |
| IN139392B (it) | 1976-06-12 |
| BR7403333D0 (pt) | 1974-11-19 |
| FR2227258B1 (it) | 1976-12-17 |
| IL44622A0 (en) | 1974-06-30 |
| NL7405716A (it) | 1974-10-29 |
| AU6822974A (en) | 1975-10-30 |
| MY7900158A (en) | 1979-12-31 |
| AU484484B2 (en) | 1975-10-30 |
| GB1425437A (en) | 1976-02-18 |
| US3925465A (en) | 1975-12-09 |
| CA1029394A (en) | 1978-04-11 |
| HK15379A (en) | 1979-03-30 |
| IT1020587B (it) | 1977-12-30 |
| BE814178A (fr) | 1974-10-25 |
| AR207952A1 (es) | 1976-11-22 |
| NL178683B (nl) | 1985-12-02 |
| IE39376B1 (en) | 1978-09-27 |
| FR2227258A1 (it) | 1974-11-22 |
| DE2419622A1 (de) | 1974-11-14 |
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