IL44304A - History 3 - Benzyl - pyrido] e - 4 [- sa, 3 - triazine and their preparation - Google Patents
History 3 - Benzyl - pyrido] e - 4 [- sa, 3 - triazine and their preparationInfo
- Publication number
- IL44304A IL44304A IL44304A IL4430474A IL44304A IL 44304 A IL44304 A IL 44304A IL 44304 A IL44304 A IL 44304A IL 4430474 A IL4430474 A IL 4430474A IL 44304 A IL44304 A IL 44304A
- Authority
- IL
- Israel
- Prior art keywords
- benzylpyrido
- triazine
- compound
- hydrochloride
- dihydro
- Prior art date
Links
- ROINDGIBYTXRFE-UHFFFAOYSA-N 3-benzylpyrido[3,4-e][1,2,4]triazine Chemical class N=1N=C2C=CN=CC2=NC=1CC1=CC=CC=C1 ROINDGIBYTXRFE-UHFFFAOYSA-N 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 230000000843 anti-fungal effect Effects 0.000 claims description 4
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 241000222122 Candida albicans Species 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- PCMRVTYTBSGXJT-UHFFFAOYSA-N 4-hydrazinylpyridin-3-amine hydrochloride Chemical compound NC=1C=NC=CC1NN.Cl PCMRVTYTBSGXJT-UHFFFAOYSA-N 0.000 claims 1
- 241000251124 Mustelus canis Species 0.000 claims 1
- 206010040880 Skin irritation Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- CJFGBCWGOQRURQ-UHFFFAOYSA-N ginsenoside Mc Natural products C1CC(C2(CCC3C(C)(C)C(O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC(C(C(O)C1O)O)OC1COC1OC(CO)C(O)C1O CJFGBCWGOQRURQ-UHFFFAOYSA-N 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000036556 skin irritation Effects 0.000 claims 1
- 231100000475 skin irritation Toxicity 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 abstract description 4
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 230000008029 eradication Effects 0.000 abstract 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- JECOSSASMXAXFV-UHFFFAOYSA-N chloroethane;hydrochloride Chemical compound Cl.CCCl JECOSSASMXAXFV-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- VYSYZMNJHYOXGN-UHFFFAOYSA-N ethyl n-aminocarbamate Chemical compound CCOC(=O)NN VYSYZMNJHYOXGN-UHFFFAOYSA-N 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US367500A US3883526A (en) | 1973-06-06 | 1973-06-06 | 3-Benzylpyrido {8 3,4-e{9 -as-triazine and 1,2-dihydro-3-benzylpyrido{8 3,4-e{9 -as-triazine hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44304A0 IL44304A0 (en) | 1974-05-16 |
| IL44304A true IL44304A (en) | 1977-05-31 |
Family
ID=23447426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44304A IL44304A (en) | 1973-06-06 | 1974-02-27 | History 3 - Benzyl - pyrido] e - 4 [- sa, 3 - triazine and their preparation |
Country Status (13)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE409863B (sv) * | 1975-08-01 | 1979-09-10 | Egyt Gyogyszervegyeszeti Gyar | Analogiforfarande for framstellning av pyrido(3,4-e)-as-triazinderivat |
| DE3064301D1 (en) * | 1979-10-18 | 1983-08-25 | Interox Chemicals Ltd | Magnesium salts of peroxycarboxylic acids, processes for their preparation and their use as bleaching agents in washing compositions, and processes |
| JPS6336085A (ja) * | 1986-07-30 | 1988-02-16 | Taiko Kikai Kogyo Kk | スクリユウ型真空ポンプ |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3597427A (en) * | 1969-01-13 | 1971-08-03 | American Cyanamid Co | 1,2-dihydropyrido(3,4-e)-as-triazines |
-
1973
- 1973-06-06 US US367500A patent/US3883526A/en not_active Expired - Lifetime
-
1974
- 1974-02-26 ZA ZA00741277A patent/ZA741277B/xx unknown
- 1974-02-27 IL IL44304A patent/IL44304A/en unknown
- 1974-03-01 GB GB943574A patent/GB1391900A/en not_active Expired
- 1974-03-18 NL NL7403598A patent/NL7403598A/xx not_active Application Discontinuation
- 1974-04-26 SE SE7405655A patent/SE7405655L/xx not_active Application Discontinuation
- 1974-05-13 AU AU68846/74A patent/AU473797B2/en not_active Expired
- 1974-05-22 JP JP49056787A patent/JPS5019772A/ja active Pending
- 1974-06-05 FR FR7419426A patent/FR2232322B1/fr not_active Expired
- 1974-06-06 CH CH774274A patent/CH591479A5/xx not_active IP Right Cessation
- 1974-06-06 BE BE145155A patent/BE816006A/xx unknown
- 1974-06-06 DK DK302274A patent/DK302274A/da unknown
- 1974-06-06 DE DE19742427382 patent/DE2427382A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU473797B2 (en) | 1976-07-01 |
| FR2232322B1 (enrdf_load_stackoverflow) | 1977-09-09 |
| FR2232322A1 (enrdf_load_stackoverflow) | 1975-01-03 |
| AU6884674A (en) | 1975-11-13 |
| BE816006A (fr) | 1974-12-06 |
| DE2427382A1 (de) | 1975-01-02 |
| IL44304A0 (en) | 1974-05-16 |
| SE7405655L (enrdf_load_stackoverflow) | 1974-12-09 |
| CH591479A5 (enrdf_load_stackoverflow) | 1977-09-15 |
| GB1391900A (en) | 1975-04-23 |
| NL7403598A (enrdf_load_stackoverflow) | 1974-12-10 |
| ZA741277B (en) | 1975-10-29 |
| JPS5019772A (enrdf_load_stackoverflow) | 1975-03-01 |
| DK302274A (enrdf_load_stackoverflow) | 1975-02-03 |
| US3883526A (en) | 1975-05-13 |
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