IL44008A - Production of antisera - Google Patents
Production of antiseraInfo
- Publication number
- IL44008A IL44008A IL44008A IL4400874A IL44008A IL 44008 A IL44008 A IL 44008A IL 44008 A IL44008 A IL 44008A IL 4400874 A IL4400874 A IL 4400874A IL 44008 A IL44008 A IL 44008A
- Authority
- IL
- Israel
- Prior art keywords
- molecular weight
- copolymer
- supernatant
- precipitate
- admixing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title description 4
- 229920001400 block copolymer Polymers 0.000 claims abstract description 15
- 210000002381 plasma Anatomy 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 12
- -1 polyoxypropylene Polymers 0.000 claims abstract description 9
- 210000002966 serum Anatomy 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims abstract description 3
- 239000006228 supernatant Substances 0.000 claims description 21
- 239000002244 precipitate Substances 0.000 claims description 19
- 239000000725 suspension Substances 0.000 claims description 9
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 238000007865 diluting Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims 7
- 239000012467 final product Substances 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 230000000717 retained effect Effects 0.000 description 11
- 229920001983 poloxamer Polymers 0.000 description 10
- 239000007858 starting material Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000463 material Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000012460 protein solution Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000013618 particulate matter Substances 0.000 description 3
- 102000006395 Globulins Human genes 0.000 description 2
- 108010044091 Globulins Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- QMHLJNFGMZBHIP-UHFFFAOYSA-N oxirane;propane-1,2-diol Chemical compound C1CO1.CC(O)CO QMHLJNFGMZBHIP-UHFFFAOYSA-N 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NYEPHMYJRNWPLA-UHFFFAOYSA-N (6-amino-2-ethoxyacridin-9-yl)azanium;2-hydroxypropanoate;hydrate Chemical compound O.CC(O)C([O-])=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3[NH+]=C21 NYEPHMYJRNWPLA-UHFFFAOYSA-N 0.000 description 1
- 102000006734 Beta-Globulins Human genes 0.000 description 1
- 108010087504 Beta-Globulins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 102000005686 Serum Globulins Human genes 0.000 description 1
- 108010045362 Serum Globulins Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- GCWPGEWXYDEQAY-NKWVEPMBSA-N [(1r,2r)-2-aminocyclohexyl]methanol Chemical compound N[C@@H]1CCCC[C@H]1CO GCWPGEWXYDEQAY-NKWVEPMBSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 231100000319 bleeding Toxicity 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US327894A US3880989A (en) | 1973-01-30 | 1973-01-30 | Production of antisera comprising fractionating plasma or serum with an ethylene oxide-polyoxypropylene block copolymer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44008A0 IL44008A0 (en) | 1974-05-16 |
| IL44008A true IL44008A (en) | 1977-08-31 |
Family
ID=23278541
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44008A IL44008A (en) | 1973-01-30 | 1974-01-15 | Production of antisera |
| IL50191A IL50191A (en) | 1973-01-30 | 1974-01-15 | Production of antisera |
| IL50191A IL50191A0 (en) | 1973-01-30 | 1976-08-03 | The production of antisera |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL50191A IL50191A (en) | 1973-01-30 | 1974-01-15 | Production of antisera |
| IL50191A IL50191A0 (en) | 1973-01-30 | 1976-08-03 | The production of antisera |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3880989A (it) |
| JP (1) | JPS49109523A (it) |
| AU (1) | AU6495374A (it) |
| BE (1) | BE810218A (it) |
| DE (1) | DE2403994A1 (it) |
| ES (1) | ES422768A1 (it) |
| FR (1) | FR2215203B1 (it) |
| GB (1) | GB1418849A (it) |
| IL (3) | IL44008A (it) |
| IT (1) | IT1053753B (it) |
| ZA (1) | ZA74353B (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148869A (en) * | 1975-03-06 | 1979-04-10 | Baxter Travenol Laboratories, Inc. | Immunological reagent and method of using same |
| CA1064396A (en) * | 1975-02-18 | 1979-10-16 | Myer L. Coval | Fractional precipitation of gamma globulin with polyethylene glycol |
| US4126605A (en) * | 1975-12-29 | 1978-11-21 | Plasmesco Ag | Process of improving the compatibility of gamma globulins |
| US4164495A (en) * | 1976-04-06 | 1979-08-14 | Nordisk Insulinlaboratorium | Method of recovering immunoglobulin using a polyol and an alkanoic acid |
| DK139056B (da) * | 1976-04-06 | 1978-12-11 | Nordisk Insulinlab | Fremgangsmåde til udvinding af immunoglobulin, der er egnet til intravenøs indgivelse. |
| US4057628A (en) * | 1976-04-19 | 1977-11-08 | William L. Wilson | Removal of hepatitis associated antigen from plasma |
| US4165370A (en) * | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
| US4087415A (en) * | 1976-06-09 | 1978-05-02 | William L. Wilson | Antithrombin III |
| US4357272A (en) * | 1978-03-22 | 1982-11-02 | The South African Inventions Development Corporation | Recovering purified antibodies from egg yolk |
| DE2814981C3 (de) * | 1978-04-07 | 1981-08-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Faktor zur Stimulation der Proliferationsrate von Leberzellen |
| JPS6029687B2 (ja) * | 1978-11-07 | 1985-07-12 | 株式会社ミドリ十字 | ヒト胎盤由来血液凝固第１０３因子の濃縮液の製造方法 |
| DE2914903C2 (de) * | 1979-04-12 | 1981-08-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Leberzellwachstumfaktor |
| US5006287A (en) * | 1988-01-14 | 1991-04-09 | The Standard Oil Company | Affinity membranes having pendant hydroxy groups and processes for the preparation and use thereof |
| US4919811A (en) * | 1988-01-14 | 1990-04-24 | The Standard Oil Company | Affinity membranes having pendant hydroxy groups and processes for the preparation and use thereof |
| JP2684069B2 (ja) * | 1988-10-13 | 1997-12-03 | 昇一 首藤 | 免疫学的活性物質の測定方法及びそのための試薬 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390074A (en) * | 1942-02-09 | 1945-12-04 | Research Corp | Protein product and process |
| NL286954A (it) * | 1962-01-03 | |||
| US3450502A (en) * | 1967-09-25 | 1969-06-17 | Wyandotte Chemicals Corp | Method of operating heart-lung apparatus |
| US3770631A (en) * | 1971-06-29 | 1973-11-06 | Baxter Laboratories Inc | Clarification of blood serum and plasma |
-
1973
- 1973-01-30 US US327894A patent/US3880989A/en not_active Expired - Lifetime
-
1974
- 1974-01-15 IL IL44008A patent/IL44008A/en unknown
- 1974-01-15 IL IL50191A patent/IL50191A/en unknown
- 1974-01-17 ZA ZA740353A patent/ZA74353B/xx unknown
- 1974-01-21 JP JP49009170A patent/JPS49109523A/ja active Pending
- 1974-01-28 IT IT19894/74A patent/IT1053753B/it active
- 1974-01-28 BE BE140218A patent/BE810218A/xx unknown
- 1974-01-29 GB GB402174A patent/GB1418849A/en not_active Expired
- 1974-01-29 FR FR7402808A patent/FR2215203B1/fr not_active Expired
- 1974-01-29 AU AU64953/74A patent/AU6495374A/en not_active Expired
- 1974-01-29 DE DE2403994A patent/DE2403994A1/de active Pending
- 1974-01-30 ES ES422768A patent/ES422768A1/es not_active Expired
-
1976
- 1976-08-03 IL IL50191A patent/IL50191A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS49109523A (it) | 1974-10-18 |
| IL50191A0 (en) | 1976-10-31 |
| IT1053753B (it) | 1981-10-10 |
| ZA74353B (en) | 1974-11-27 |
| FR2215203B1 (it) | 1976-09-03 |
| IL44008A0 (en) | 1974-05-16 |
| DE2403994A1 (de) | 1974-08-08 |
| ES422768A1 (es) | 1976-08-01 |
| AU6495374A (en) | 1975-07-31 |
| BE810218A (fr) | 1974-05-16 |
| IL50191A (en) | 1977-08-31 |
| FR2215203A1 (it) | 1974-08-23 |
| US3880989A (en) | 1975-04-29 |
| GB1418849A (en) | 1975-12-24 |
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