IL43470A - 2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL43470A IL43470A IL43470A IL4347073A IL43470A IL 43470 A IL43470 A IL 43470A IL 43470 A IL43470 A IL 43470A IL 4347073 A IL4347073 A IL 4347073A IL 43470 A IL43470 A IL 43470A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- methylamine
- formula
- formula iii
- methylamine methylamine
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 3
- QJODJSOWQNYRDH-UHFFFAOYSA-N 3-phenylbicyclo[2.2.2]octane Chemical class C1CC2CCC1CC2C1=CC=CC=C1 QJODJSOWQNYRDH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 25
- 238000000034 method Methods 0.000 claims 11
- BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 2
- 239000012954 diazonium Substances 0.000 claims 2
- 150000001989 diazonium salts Chemical class 0.000 claims 2
- 238000006193 diazotization reaction Methods 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- -1 methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine propylamine Chemical compound 0.000 claims 2
- 238000006722 reduction reaction Methods 0.000 claims 2
- 238000006268 reductive amination reaction Methods 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000005576 amination reaction Methods 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940066769 systemic antihistamines substituted alkylamines Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/453—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5093172A GB1444717A (en) | 1972-11-04 | 1972-11-04 | Bicycloalkyl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43470A0 IL43470A0 (en) | 1974-01-14 |
| IL43470A true IL43470A (en) | 1976-08-31 |
Family
ID=10457988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43470A IL43470A (en) | 1972-11-04 | 1973-10-23 | 2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (11)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1549174A (en) * | 1975-05-08 | 1979-08-01 | Lilly Industries Ltd | Amine derivatives |
| GB1551035A (en) * | 1975-07-24 | 1979-08-22 | Lilly Industries Ltd | Derivatives of bicyclo (2,2,2)oct-3-ylmethylamine |
| US4215074A (en) * | 1978-07-15 | 1980-07-29 | Lilly Industries Limited | Process for preparing cis-bicyclooctylamines |
| GB2367554A (en) * | 2000-10-04 | 2002-04-10 | Lilly Co Eli | Pharmacologically active amines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1468808A1 (de) * | 1965-04-21 | 1969-04-17 | Du Pont | Verfahren zur Herstellung von substituierten Phenylbicyclo-(2,2,2)-octanen |
-
1972
- 1972-11-04 GB GB5093172A patent/GB1444717A/en not_active Expired
-
1973
- 1973-10-12 IE IE1824/73A patent/IE38375B1/xx unknown
- 1973-10-23 IL IL43470A patent/IL43470A/en unknown
- 1973-10-30 SE SE7314756A patent/SE419980B/xx unknown
- 1973-10-31 FR FR7338821A patent/FR2205324B1/fr not_active Expired
- 1973-10-31 BE BE137315A patent/BE806808A/xx not_active IP Right Cessation
- 1973-11-01 NL NLAANVRAGE7315031,A patent/NL182143C/xx not_active IP Right Cessation
- 1973-11-02 DK DK593573AA patent/DK142111B/da not_active IP Right Cessation
- 1973-11-02 JP JP48123891A patent/JPS5747664B2/ja not_active Expired
- 1973-11-02 DE DE2354931A patent/DE2354931C2/de not_active Expired
- 1973-11-02 CH CH1542273A patent/CH588440A5/xx not_active IP Right Cessation
-
1982
- 1982-02-05 JP JP57018087A patent/JPS5936973B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2205324A1 (enrdf_load_html_response) | 1974-05-31 |
| DK142111C (enrdf_load_html_response) | 1981-02-02 |
| IL43470A0 (en) | 1974-01-14 |
| NL182143C (nl) | 1988-01-18 |
| BE806808A (fr) | 1974-04-30 |
| CH588440A5 (enrdf_load_html_response) | 1977-05-31 |
| NL7315031A (enrdf_load_html_response) | 1974-05-07 |
| IE38375B1 (en) | 1978-03-01 |
| GB1444717A (en) | 1976-08-04 |
| NL182143B (nl) | 1987-08-17 |
| SE419980B (sv) | 1981-09-07 |
| JPS57171941A (en) | 1982-10-22 |
| JPS5747664B2 (enrdf_load_html_response) | 1982-10-12 |
| DK142111B (da) | 1980-09-01 |
| DE2354931C2 (de) | 1983-12-08 |
| FR2205324B1 (enrdf_load_html_response) | 1976-05-14 |
| IE38375L (en) | 1974-05-04 |
| JPS49132058A (enrdf_load_html_response) | 1974-12-18 |
| JPS5936973B2 (ja) | 1984-09-06 |
| DE2354931A1 (de) | 1974-05-09 |
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