IL43378A - Aqueous buffer solution for use as a plasma substitute - Google Patents
Aqueous buffer solution for use as a plasma substituteInfo
- Publication number
- IL43378A IL43378A IL43378A IL4337873A IL43378A IL 43378 A IL43378 A IL 43378A IL 43378 A IL43378 A IL 43378A IL 4337873 A IL4337873 A IL 4337873A IL 43378 A IL43378 A IL 43378A
- Authority
- IL
- Israel
- Prior art keywords
- buffer solution
- aqueous buffer
- alkali metal
- salt
- carcinoembryonic antigen
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Abstract
A composition suitable for use as a substitute for blood plasma extract in producing antiserum titration curves and standard antigen inhibition curves for the determination of carcinoembryonic antigen in human plasma is disclosed.
[US3852415A]
Claims (16)
1. An aqueous buffer solution suitable for use as a plasma substitute during the production of antiserum titration ' .curves-and-s-tanda-rd-an-tigen—i-nhibi-tion-curves~for-th~e~~d¾"ter-mination of carcinoembryonic antigen in human plasma having a pH of about 6.5 comprising per liter, a. salt of ethylenediamine tetraacetic acid with an alkali metal in an amount equivalent to about 1.3 grams per liter of disodium ethylenediamine tetraacetic acid dihydrate, a preservative to inhibit the growth of microorganisms, and an alkali metal hydroxide.
2. An aqueous buffer solution as claimed in claim 1 wherein the alkali metal of the salt is the same as the alkali metal of the hydroxide.
3. An aqueous buffer solution as claimed in claim 1 or claim 2 wherein the alkali metal is sodium.
4. An aqueous buffer solution as. claimed in any one of the preceding claims wherein the salt is disodium ethylenediamine tetraacetic acid dihydrate.
5. An aqueous- buffer- solution- as~ claimed i an one of the preceding claims wherein the salt is present in an amount equivalent to 1.25 to 1.32 gm/liter of disodium ethylenediamine tetraacetic acid dihydrate. 43378/2
6. An aqueous buffer solution as claimed in anyone of the preceding claims having a pH of from 6.45 to 6.55.
7. An aqueous buffer solution as claimed in any one of the preceding claims also containing a proteinaceous material which is inert to CEA antibody-antigen reactions.
8. An aqueous buffer solution as claimed in claim 7, containing, as the proteinaceous material, bovine serum albumin.
9. An aqueous buffer solution as claimed in claim 8 containing 70 ϋΐβΓβ/ϋΐβΓ of bovine serum albumin.
10. An aqueous buffer solution as claimed in any one of the preceding claims wherein the preservative is sodium azide.
11. .11. An aqueous buffer solution as claimed in claim 10 containing 0.17 gm/liter of sodium azide. 43378/2
12. A concentrate suitable for the preparation, by the addition of deionized or distilled water, of an aqueous buffer solution as claimed in any one of the preceding claims.
13. A concentrate as claimed in claim 12 having an pH of about 6.25 comprising, a salt of an organic acid with an alkali metal in an amount equivalent to about 13 grams per liter of disodium ethylenediamine tetra- acetic acid dihydrate, a preservative to inhibit, the growth of microorganisms* and an alkali metal hydroxide.
14. An aqueous buffer solution in concentrated or diluted form as claimed in any one of the preceding claims substantially as hereinbefore described with particular reference to Examples 1 and 2.
15. A process for the preparation of a carcinoembryonic antigen antiserum titration curve or a carcinoembryonic antigen standard antigen inhibition curve, wherein in place of blood plasma extract a buffer solution as claimed in any one of claims 1 to 11 is employed.
16. A process for the preparation of a carcinoembryonic antigen antiserum titration curve or an carcinoembryonic antigen standard antigen inhibition curve substantially as hereinbefore described with particular reference to the foregoing Examples 5/ 6, 8 and 9· AN/PAJHNj
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00297565A US3852415A (en) | 1972-10-13 | 1972-10-13 | Compositions for use in radioimmunoassay as a substitute for blood plasma extract in determination of carcinoembryonic antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43378A0 IL43378A0 (en) | 1974-01-14 |
| IL43378A true IL43378A (en) | 1976-04-30 |
Family
ID=23146844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43378A IL43378A (en) | 1972-10-13 | 1973-10-04 | Aqueous buffer solution for use as a plasma substitute |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3852415A (en) |
| JP (1) | JPS5315130B2 (en) |
| AU (1) | AU467511B2 (en) |
| BE (1) | BE805991A (en) |
| CA (1) | CA1012458A (en) |
| CH (1) | CH584409A5 (en) |
| DD (1) | DD108151A5 (en) |
| DE (1) | DE2349738C3 (en) |
| FR (1) | FR2203525A5 (en) |
| GB (1) | GB1423244A (en) |
| IL (1) | IL43378A (en) |
| IT (1) | IT1001584B (en) |
| NL (1) | NL161884C (en) |
| SE (1) | SE417460B (en) |
| ZA (2) | ZA723264B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901870A (en) * | 1974-03-12 | 1975-08-26 | Behringwerke Ag | Derivative of alpha' 1'-fetospecific serum protein and process for its manufacture |
| US4132769A (en) * | 1974-10-30 | 1979-01-02 | Osther Kurt B | Cancer antigen, cancer therapy, and cancer diagnosis |
| US3999944A (en) * | 1975-02-28 | 1976-12-28 | Hoffmann-La Roche Inc. | Detection of breast cancer |
| US4043757A (en) * | 1975-05-20 | 1977-08-23 | Ortho Pharmaceutical Corporation | Method for detection of human mammary carcinoma |
| US4152410A (en) * | 1975-09-03 | 1979-05-01 | Eisai Co., Ltd. | Diagnosis reagent for neoplasm and method for diagnosis of neoplasm |
| US4379839A (en) * | 1977-05-23 | 1983-04-12 | The Trustees Of Columbia University In The City Of New York | Method for detecting cancer |
| JPS562557A (en) * | 1979-06-22 | 1981-01-12 | Green Cross Corp:The | Aqueous solvent for coagulation test |
| US4349528A (en) * | 1979-11-21 | 1982-09-14 | The Wistar Institute | Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen |
| JPS57208459A (en) * | 1981-06-19 | 1982-12-21 | Eisai Co Ltd | Measuring method using enzyme-labelled antibody and reagent |
| US4631254A (en) * | 1982-12-06 | 1986-12-23 | Hoffmann-La Roche Inc. | Carcinoembryonic antigen determination |
| US4624916A (en) * | 1984-04-06 | 1986-11-25 | International Immunoassay Laboratories, Inc. | Process and composition for the rapid quantitation of small levels of creative kinase-MB isoenzyme |
| JPS61280566A (en) * | 1984-09-03 | 1986-12-11 | Hiroaki Sawai | Direct immunoassay of 2'-5'-oligoadenylic acid |
| US4690772A (en) * | 1985-06-03 | 1987-09-01 | National Medical Care | Sterilant compositions |
| US6013772A (en) * | 1986-08-13 | 2000-01-11 | Bayer Corporation | Antibody preparations specifically binding to unique determinants of CEA antigens or fragments thereof and use of the antibody preparations in immunoassays |
| CA1296253C (en) * | 1986-10-20 | 1992-02-25 | Praveen Tyle | Stabilized growth hormone compositions |
| US5296377A (en) * | 1992-12-15 | 1994-03-22 | Boehringer Mannheim Corporation | Control reagent containing a hydroxylamine or an antioxidant |
| MX349265B (en) | 2010-05-20 | 2017-07-20 | Ecolab Usa Inc | Rheology modified low foaming liquid antimicrobial compositions and methods of use thereof. |
| KR102384708B1 (en) * | 2020-06-19 | 2022-04-11 | 대한민국 | Artificial blood for bloodstain pattern analysis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US3697638A (en) * | 1970-06-01 | 1972-10-10 | Hoffmann La Roche | Antigens |
-
1972
- 1972-05-15 ZA ZA723264A patent/ZA723264B/en unknown
- 1972-10-13 US US00297565A patent/US3852415A/en not_active Expired - Lifetime
-
1973
- 1973-10-01 CH CH1403573A patent/CH584409A5/xx not_active IP Right Cessation
- 1973-10-01 ZA ZA737693A patent/ZA737693B/en unknown
- 1973-10-02 CA CA182,470A patent/CA1012458A/en not_active Expired
- 1973-10-03 DE DE2349738A patent/DE2349738C3/en not_active Expired
- 1973-10-04 IL IL43378A patent/IL43378A/en unknown
- 1973-10-08 IT IT29875/73A patent/IT1001584B/en active
- 1973-10-10 AU AU61242/73A patent/AU467511B2/en not_active Expired
- 1973-10-11 FR FR7336328A patent/FR2203525A5/fr not_active Expired
- 1973-10-12 DD DD174034A patent/DD108151A5/xx unknown
- 1973-10-12 SE SE7313919A patent/SE417460B/en unknown
- 1973-10-12 GB GB4780473A patent/GB1423244A/en not_active Expired
- 1973-10-12 NL NL7314093.A patent/NL161884C/en not_active IP Right Cessation
- 1973-10-12 BE BE136609A patent/BE805991A/en not_active IP Right Cessation
- 1973-10-12 JP JP11463773A patent/JPS5315130B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3852415A (en) | 1974-12-03 |
| JPS4971133A (en) | 1974-07-10 |
| AU6124273A (en) | 1975-05-01 |
| IT1001584B (en) | 1976-04-30 |
| NL161884B (en) | 1979-10-15 |
| IL43378A0 (en) | 1974-01-14 |
| DE2349738A1 (en) | 1974-04-18 |
| SE417460B (en) | 1981-03-16 |
| NL7314093A (en) | 1974-04-16 |
| DE2349738B2 (en) | 1978-01-19 |
| ZA723264B (en) | 1974-08-28 |
| AU467511B2 (en) | 1975-12-04 |
| JPS5315130B2 (en) | 1978-05-23 |
| ZA737693B (en) | 1974-08-28 |
| BE805991A (en) | 1974-04-12 |
| GB1423244A (en) | 1976-02-04 |
| CH584409A5 (en) | 1977-01-31 |
| DE2349738C3 (en) | 1981-06-19 |
| FR2203525A5 (en) | 1974-05-10 |
| CA1012458A (en) | 1977-06-21 |
| NL161884C (en) | 1980-03-17 |
| DD108151A5 (en) | 1974-09-05 |
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