GB1182983A - Fermentation Process for the Production of Citric Acid. - Google Patents

Fermentation Process for the Production of Citric Acid.

Info

Publication number
GB1182983A
GB1182983A GB25572/68A GB2557268A GB1182983A GB 1182983 A GB1182983 A GB 1182983A GB 25572/68 A GB25572/68 A GB 25572/68A GB 2557268 A GB2557268 A GB 2557268A GB 1182983 A GB1182983 A GB 1182983A
Authority
GB
United Kingdom
Prior art keywords
citric acid
medium
recovered
per litre
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25572/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB1182983A publication Critical patent/GB1182983A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/48—Tricarboxylic acids, e.g. citric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1,182,983. Citric acid. CHAS. PFIZER & CO. Inc. 28 May, 1968 [14 Dec., 1967], No. 25572/68. Heading C2C. [Also in Division C6] A citric acid-accumulating yeast strain of the genera Candida, Endomycopsis, Hansenula, Pichia or Torulopsis, is propagated under aerobic conditions in an aqueous carbohydratecontaining medium until a level of at least 1 gram of citric acid accumulates per litre of medium, and the citric acid is recovered. The pH is maintained between 1.5 and 8, and the temperature between 20‹ and 37‹ C. during the propagating. The medium may contain 5-25 grams of calcium carbonate per litre (or similar basic substance) whereby the citric acid is recovered in the form of a precipitate of calcium citrate. The accumulation of citric acid is enhanced by the inclusion in the medium of a minute amount of an α-chloro- or α-fluorosubstituted lower alkanoic mono- or di-carboxylic acid (containing up to 4 carbon atoms) or the corresponding salt or amide, exemplified by chloroacetic, fluoroacetic, trichloroacetic, trifluoroacetic and chlorosuccinic acids, and sodium, potassium, ammonium, lithium, cadmium, barium and amine addition salts. Species and strains of yeasts, and carbohydrate and nitrogen sources for the medium, are specifically mentioned.
GB25572/68A 1967-12-14 1968-05-28 Fermentation Process for the Production of Citric Acid. Expired GB1182983A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69037567A 1967-12-14 1967-12-14

Publications (1)

Publication Number Publication Date
GB1182983A true GB1182983A (en) 1970-03-04

Family

ID=24772210

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25572/68A Expired GB1182983A (en) 1967-12-14 1968-05-28 Fermentation Process for the Production of Citric Acid.

Country Status (9)

Country Link
BE (1) BE723829A (en)
BR (1) BR6803901D0 (en)
CA (1) CA942218A (en)
DE (1) DE1808615B2 (en)
ES (1) ES360190A1 (en)
FR (1) FR1593170A (en)
GB (1) GB1182983A (en)
IL (1) IL30978A (en)
NL (1) NL6816175A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5324516B1 (en) * 1970-04-02 1978-07-21

Also Published As

Publication number Publication date
IL30978A0 (en) 1968-12-26
BR6803901D0 (en) 1973-08-09
DE1808615B2 (en) 1974-04-18
BE723829A (en) 1969-05-14
CA942218A (en) 1974-02-19
FR1593170A (en) 1970-05-25
DE1808615A1 (en) 1969-07-17
ES360190A1 (en) 1970-07-01
NL6816175A (en) 1969-06-17
IL30978A (en) 1972-08-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years