IL43329A - Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them - Google Patents

Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them

Info

Publication number
IL43329A
IL43329A IL7343329A IL4332973A IL43329A IL 43329 A IL43329 A IL 43329A IL 7343329 A IL7343329 A IL 7343329A IL 4332973 A IL4332973 A IL 4332973A IL 43329 A IL43329 A IL 43329A
Authority
IL
Israel
Prior art keywords
acid
ester
general
compound according
hereinbefore described
Prior art date
Application number
IL7343329A
Other languages
English (en)
Other versions
IL43329A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL43329A0 publication Critical patent/IL43329A0/xx
Publication of IL43329A publication Critical patent/IL43329A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL7343329A 1972-09-30 1973-09-26 Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them IL43329A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722248150 DE2248150A1 (de) 1972-09-30 1972-09-30 Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
IL43329A0 IL43329A0 (en) 1973-11-28
IL43329A true IL43329A (en) 1977-04-29

Family

ID=5857927

Family Applications (1)

Application Number Title Priority Date Filing Date
IL7343329A IL43329A (en) 1972-09-30 1973-09-26 Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US3905983A (no)
JP (1) JPS5647905B2 (no)
AT (1) AT330175B (no)
AU (1) AU476129B2 (no)
BE (1) BE805451A (no)
CA (1) CA1005061A (no)
CH (3) CH605752A5 (no)
CS (3) CS178440B2 (no)
DD (1) DD110659A5 (no)
DE (1) DE2248150A1 (no)
DK (1) DK137722C (no)
ES (3) ES419193A1 (no)
FR (1) FR2201095B1 (no)
GB (1) GB1389509A (no)
HU (1) HU166357B (no)
IE (1) IE38335B1 (no)
IL (1) IL43329A (no)
LU (1) LU68530A1 (no)
NL (1) NL7313422A (no)
PL (3) PL92084B1 (no)
SE (1) SE403777B (no)
ZA (1) ZA737659B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970662A (en) * 1975-06-19 1976-07-20 Sterling Drug Inc. 4-(3-Nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid and intermediates
US4338322A (en) * 1975-07-02 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
DK152285C (da) * 1975-07-02 1988-10-10 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
US4055588A (en) * 1976-02-20 1977-10-25 Sterling Drug Inc. Tetra-(lower-alkyl)3-(3-nitrophenyl)-1,5-pentanedione-1,2,4,5-tetracarboxylates
DE2837477A1 (de) * 1978-08-28 1980-03-13 Bayer Ag Sila-substituierte 1,4-dihydropyridin- derivate
DE3022002A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-4-carbonsaeureamide, verfahren zu deren herstellung, sowie diese enthaltende arzneimittel
CS228917B2 (en) 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
EP0107293A3 (en) * 1982-09-04 1984-06-06 Pfizer Limited Dihydropyridines
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
JPS59144249U (ja) * 1983-03-16 1984-09-27 株式会社御田釦製作所 紐類の端末処理具
EP0125803A3 (en) * 1983-04-27 1987-01-21 FISONS plc Pharmaceutically active dihydropyridines
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
FI862343A (fi) 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
DE3629545A1 (de) * 1986-08-30 1988-03-10 Bayer Ag Dihydropyridinverbindungen, verfahren zu ihrer herstellung und ihre verwendung
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
IE38335L (en) 1974-03-30
CS178435B2 (no) 1977-09-15
ES419193A1 (es) 1976-12-16
LU68530A1 (no) 1973-12-10
CH605752A5 (no) 1978-10-13
PL92084B1 (no) 1977-03-31
GB1389509A (en) 1975-04-03
CS178440B2 (no) 1977-09-15
DK137722C (da) 1978-10-02
ES443521A1 (es) 1977-05-16
CA1005061A (en) 1977-02-08
AT330175B (de) 1976-06-25
BE805451A (fr) 1974-03-28
AU476129B2 (en) 1976-09-09
IL43329A0 (en) 1973-11-28
DE2248150A1 (de) 1974-04-04
AU6071673A (en) 1975-03-27
CH583703A5 (no) 1977-01-14
JPS5647905B2 (no) 1981-11-12
FR2201095B1 (no) 1977-09-09
IE38335B1 (en) 1978-02-15
PL92079B1 (no) 1977-03-31
DD110659A5 (no) 1974-01-05
US3905983A (en) 1975-09-16
SE403777B (sv) 1978-09-04
FR2201095A1 (no) 1974-04-26
DK137722B (da) 1978-04-24
PL91085B1 (no) 1977-02-28
HU166357B (no) 1975-03-28
ZA737659B (en) 1974-08-28
ATA834773A (de) 1975-09-15
NL7313422A (no) 1974-04-02
ES443522A1 (es) 1977-05-01
JPS4970977A (no) 1974-07-09
CS178441B2 (no) 1977-09-15
CH601233A5 (no) 1978-06-30

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