IL43329A - Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them - Google Patents
Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing themInfo
- Publication number
- IL43329A IL43329A IL7343329A IL4332973A IL43329A IL 43329 A IL43329 A IL 43329A IL 7343329 A IL7343329 A IL 7343329A IL 4332973 A IL4332973 A IL 4332973A IL 43329 A IL43329 A IL 43329A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- ester
- general
- compound according
- hereinbefore described
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722248150 DE2248150A1 (de) | 1972-09-30 | 1972-09-30 | Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43329A0 IL43329A0 (en) | 1973-11-28 |
| IL43329A true IL43329A (en) | 1977-04-29 |
Family
ID=5857927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL7343329A IL43329A (en) | 1972-09-30 | 1973-09-26 | Dihydropyridine-di tri or tetra carboxylates their production and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3905983A (da) |
| JP (1) | JPS5647905B2 (da) |
| AT (1) | AT330175B (da) |
| AU (1) | AU476129B2 (da) |
| BE (1) | BE805451A (da) |
| CA (1) | CA1005061A (da) |
| CH (3) | CH605752A5 (da) |
| CS (3) | CS178441B2 (da) |
| DD (1) | DD110659A5 (da) |
| DE (1) | DE2248150A1 (da) |
| DK (1) | DK137722C (da) |
| ES (3) | ES419193A1 (da) |
| FR (1) | FR2201095B1 (da) |
| GB (1) | GB1389509A (da) |
| HU (1) | HU166357B (da) |
| IE (1) | IE38335B1 (da) |
| IL (1) | IL43329A (da) |
| LU (1) | LU68530A1 (da) |
| NL (1) | NL7313422A (da) |
| PL (3) | PL91085B1 (da) |
| SE (1) | SE403777B (da) |
| ZA (1) | ZA737659B (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3970662A (en) * | 1975-06-19 | 1976-07-20 | Sterling Drug Inc. | 4-(3-Nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid and intermediates |
| DK152285C (da) * | 1975-07-02 | 1988-10-10 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater |
| US4338322A (en) * | 1975-07-02 | 1982-07-06 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same |
| GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
| FR2320750A1 (fr) * | 1975-08-12 | 1977-03-11 | Hexachimie | Dihydro-1,4 pyridines et leur application therapeutique |
| US4055588A (en) * | 1976-02-20 | 1977-10-25 | Sterling Drug Inc. | Tetra-(lower-alkyl)3-(3-nitrophenyl)-1,5-pentanedione-1,2,4,5-tetracarboxylates |
| DE2837477A1 (de) * | 1978-08-28 | 1980-03-13 | Bayer Ag | Sila-substituierte 1,4-dihydropyridin- derivate |
| DE3022002A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridin-4-carbonsaeureamide, verfahren zu deren herstellung, sowie diese enthaltende arzneimittel |
| CS228917B2 (en) | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| US4497808A (en) * | 1981-12-30 | 1985-02-05 | Ciba-Geigy Corporation | N-Oxide compounds useful in the treatment of cardiovascular ailments |
| DE3363743D1 (en) * | 1982-07-22 | 1986-07-03 | Pfizer Ltd | Dihydropyridine anti-ischaemic and antihypertensive agents |
| EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
| PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
| JPS59144249U (ja) * | 1983-03-16 | 1984-09-27 | 株式会社御田釦製作所 | 紐類の端末処理具 |
| EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
| US4678796A (en) * | 1984-11-30 | 1987-07-07 | Warner-Lambert Company | 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
| FI862343A (fi) | 1985-06-17 | 1986-12-18 | Warner Lambert Co | Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar. |
| US4732898A (en) * | 1986-04-29 | 1988-03-22 | Warner-Lambert Company | 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
| DE3629545A1 (de) * | 1986-08-30 | 1988-03-10 | Bayer Ag | Dihydropyridinverbindungen, verfahren zu ihrer herstellung und ihre verwendung |
| JPH0688973B2 (ja) * | 1987-03-12 | 1994-11-09 | 京都薬品工業株式会社 | １，４−ジヒドロピリジン誘導体 |
| US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117572C3 (de) * | 1971-04-10 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
-
1972
- 1972-09-30 DE DE19722248150 patent/DE2248150A1/de active Pending
-
1973
- 1973-09-24 US US399850A patent/US3905983A/en not_active Expired - Lifetime
- 1973-09-25 CA CA181,860A patent/CA1005061A/en not_active Expired
- 1973-09-26 AU AU60716/73A patent/AU476129B2/en not_active Expired
- 1973-09-26 IL IL7343329A patent/IL43329A/en unknown
- 1973-09-27 DD DD173732A patent/DD110659A5/xx unknown
- 1973-09-28 NL NL7313422A patent/NL7313422A/xx not_active Application Discontinuation
- 1973-09-28 AT AT834773A patent/AT330175B/de active
- 1973-09-28 IE IE1735/73A patent/IE38335B1/xx unknown
- 1973-09-28 CH CH1113776A patent/CH605752A5/xx not_active IP Right Cessation
- 1973-09-28 BE BE136158A patent/BE805451A/xx unknown
- 1973-09-28 FR FR7334944A patent/FR2201095B1/fr not_active Expired
- 1973-09-28 DK DK533473A patent/DK137722C/da active
- 1973-09-28 CH CH1390273A patent/CH583703A5/xx not_active IP Right Cessation
- 1973-09-28 HU HUBA2984A patent/HU166357B/hu unknown
- 1973-09-28 LU LU68530A patent/LU68530A1/xx unknown
- 1973-09-28 ZA ZA737659*A patent/ZA737659B/xx unknown
- 1973-09-28 JP JP10862773A patent/JPS5647905B2/ja not_active Expired
- 1973-09-28 GB GB4548173A patent/GB1389509A/en not_active Expired
- 1973-09-29 PL PL1973165524A patent/PL91085B1/pl unknown
- 1973-09-29 PL PL1973182553A patent/PL92079B1/pl unknown
- 1973-09-29 PL PL1973182552A patent/PL92084B1/pl unknown
- 1973-09-29 ES ES419193A patent/ES419193A1/es not_active Expired
- 1973-10-01 SE SE7313187A patent/SE403777B/xx unknown
- 1973-10-01 CS CS5597A patent/CS178441B2/cs unknown
- 1973-10-01 CS CS6765A patent/CS178435B2/cs unknown
- 1973-10-01 CS CS5596A patent/CS178440B2/cs unknown
-
1975
- 1975-12-16 ES ES443521A patent/ES443521A1/es not_active Expired
- 1975-12-16 ES ES443522A patent/ES443522A1/es not_active Expired
-
1977
- 1977-09-28 CH CH538177A patent/CH601233A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LU68530A1 (da) | 1973-12-10 |
| SE403777B (sv) | 1978-09-04 |
| ES443522A1 (es) | 1977-05-01 |
| AU476129B2 (en) | 1976-09-09 |
| ZA737659B (en) | 1974-08-28 |
| PL92084B1 (da) | 1977-03-31 |
| FR2201095B1 (da) | 1977-09-09 |
| DK137722B (da) | 1978-04-24 |
| JPS5647905B2 (da) | 1981-11-12 |
| IE38335B1 (en) | 1978-02-15 |
| BE805451A (fr) | 1974-03-28 |
| CA1005061A (en) | 1977-02-08 |
| CS178441B2 (da) | 1977-09-15 |
| DD110659A5 (da) | 1974-01-05 |
| ATA834773A (de) | 1975-09-15 |
| ES419193A1 (es) | 1976-12-16 |
| PL92079B1 (da) | 1977-03-31 |
| CH605752A5 (da) | 1978-10-13 |
| FR2201095A1 (da) | 1974-04-26 |
| AU6071673A (en) | 1975-03-27 |
| CH583703A5 (da) | 1977-01-14 |
| ES443521A1 (es) | 1977-05-16 |
| JPS4970977A (da) | 1974-07-09 |
| US3905983A (en) | 1975-09-16 |
| CS178435B2 (da) | 1977-09-15 |
| DE2248150A1 (de) | 1974-04-04 |
| PL91085B1 (da) | 1977-02-28 |
| NL7313422A (da) | 1974-04-02 |
| CH601233A5 (da) | 1978-06-30 |
| GB1389509A (en) | 1975-04-03 |
| HU166357B (da) | 1975-03-28 |
| DK137722C (da) | 1978-10-02 |
| AT330175B (de) | 1976-06-25 |
| IE38335L (en) | 1974-03-30 |
| IL43329A0 (en) | 1973-11-28 |
| CS178440B2 (da) | 1977-09-15 |
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