IL42858A - 2-amino-7,7-diethyl-6-hydroxymethyl-7,8-dihydro-4-pteridinones,their preparation and pharmaceutical compositions containing them - Google Patents

2-amino-7,7-diethyl-6-hydroxymethyl-7,8-dihydro-4-pteridinones,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL42858A
IL42858A IL42858A IL4285873A IL42858A IL 42858 A IL42858 A IL 42858A IL 42858 A IL42858 A IL 42858A IL 4285873 A IL4285873 A IL 4285873A IL 42858 A IL42858 A IL 42858A
Authority
IL
Israel
Prior art keywords
compound
formula
salt
prepared
acid
Prior art date
Application number
IL42858A
Other languages
English (en)
Other versions
IL42858A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL42858A0 publication Critical patent/IL42858A0/xx
Publication of IL42858A publication Critical patent/IL42858A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C207/00Compounds containing nitroso groups bound to a carbon skeleton
    • C07C207/04Compounds containing nitroso groups bound to a carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/02Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL42858A 1972-08-01 1973-07-31 2-amino-7,7-diethyl-6-hydroxymethyl-7,8-dihydro-4-pteridinones,their preparation and pharmaceutical compositions containing them IL42858A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3581472A GB1454165A (en) 1972-08-01 1972-08-01 Biologically active compounds and compositions

Publications (2)

Publication Number Publication Date
IL42858A0 IL42858A0 (en) 1973-10-25
IL42858A true IL42858A (en) 1977-02-28

Family

ID=10381816

Family Applications (1)

Application Number Title Priority Date Filing Date
IL42858A IL42858A (en) 1972-08-01 1973-07-31 2-amino-7,7-diethyl-6-hydroxymethyl-7,8-dihydro-4-pteridinones,their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US3963719A (US07816562-20101019-C00012.png)
JP (1) JPS4955692A (US07816562-20101019-C00012.png)
BE (1) BE803090A (US07816562-20101019-C00012.png)
CA (1) CA1019736A (US07816562-20101019-C00012.png)
CH (1) CH609985A5 (US07816562-20101019-C00012.png)
DE (1) DE2338787A1 (US07816562-20101019-C00012.png)
DK (1) DK138019B (US07816562-20101019-C00012.png)
ES (2) ES417415A1 (US07816562-20101019-C00012.png)
FI (1) FI55662C (US07816562-20101019-C00012.png)
FR (1) FR2194438B1 (US07816562-20101019-C00012.png)
GB (1) GB1454165A (US07816562-20101019-C00012.png)
HU (1) HU171199B (US07816562-20101019-C00012.png)
IL (1) IL42858A (US07816562-20101019-C00012.png)
NL (1) NL7310579A (US07816562-20101019-C00012.png)
SE (1) SE407576B (US07816562-20101019-C00012.png)
ZA (1) ZA735210B (US07816562-20101019-C00012.png)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635978A (en) * 1969-01-28 1972-01-18 Univ Strathclyde Amino pyrimidines
GB1363064A (en) * 1970-07-27 1974-08-14 Wellcome Found Pyrimidine derivatives as intermediates in the synthesis of pteridines
BE787236A (fr) * 1971-08-05 1973-02-05 Wellcome Found Compositions de potentialisation

Also Published As

Publication number Publication date
NL7310579A (US07816562-20101019-C00012.png) 1974-02-05
FR2194438B1 (US07816562-20101019-C00012.png) 1976-07-02
ZA735210B (en) 1975-03-26
US3963719A (en) 1976-06-15
HU171199B (hu) 1977-11-28
CA1019736A (en) 1977-10-25
DK138019B (da) 1978-06-26
DE2338787A1 (de) 1974-02-14
DK138019C (US07816562-20101019-C00012.png) 1978-11-13
GB1454165A (en) 1976-10-27
IL42858A0 (en) 1973-10-25
SE407576B (sv) 1979-04-02
BE803090A (fr) 1974-01-31
CH609985A5 (US07816562-20101019-C00012.png) 1979-03-30
ES417415A1 (es) 1976-06-16
FR2194438A1 (US07816562-20101019-C00012.png) 1974-03-01
ES442673A1 (es) 1977-04-16
JPS4955692A (US07816562-20101019-C00012.png) 1974-05-30
AU5873273A (en) 1975-02-06
FI55662B (fi) 1979-05-31
FI55662C (fi) 1979-09-10

Similar Documents

Publication Publication Date Title
US4232022A (en) Heterocyclic compounds
Neil et al. Biochemical and Pharmacological Effects of the Fermentation-derived Antitumor Agent,(α S, 5 S)-α-Amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic Acid (AT-125)
EP0760818A1 (de) Verwendung von tetrahydropteridin-derivaten als hemmstoffe der no-synthase
HUT67711A (en) Tetrahydropyrimidine derivatives and pharmaceutical compositions comprising them
EP0760664A1 (de) Verwendung von pteridin-derivaten als hemmstoffe der no-synthase
DE102004029784A1 (de) Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DD201896A5 (de) Verfahren zur herstellung neuer in 5-position substituierter 2,4-diamino-pyrimidine
Mead et al. The effect of reduced derivatives of folic acid on toxicity and antileukemic effect of methotrexate in mice
US4532240A (en) Diaminopyrimidines
US4073786A (en) 2-Amino-4-hydroxy-6-hydroxymethyl-7,7-diethyl-7,8-dihydropteridine and the 7-spirocyclohexyl analogue thereof
US3963719A (en) 6-Spirocycloalkylamino 5-nitropyrimidines
US4992444A (en) Antifolate agents
DE2238536C2 (de) Zubereitungen zur Behandlung von Mikrobeninfektionen
US3939160A (en) Pteridines
US4156725A (en) Bacteriostatic biologically active compositions
US4036961A (en) Pharmaceutical compositions containing pteridines
US4044130A (en) Compositions for the control of microorganisms
US4795639A (en) Potentiating formulations
US3933820A (en) 5-Nitropyrimidines
CA1050981A (en) Intermediates for pteridine derivatives
US4042589A (en) Pteridine compounds
US4303790A (en) 2-Amino-4-imino-6-hydrazinopyrimidine
JPS6399061A (ja) ベンジルピリミジン誘導体、その製造方法及びそれを含有する医薬
IL44124A (en) Compositions containing 2-amino-4-hydroxy-7,8-dihydro pteridine derivatives for treating microbial infections
IL44123A (en) 2-amino-4-hydroxy-7,8-dihydropteridine-6-carboxaldehyde derivatives their preparation and pharmaceutical compositions containing them