IL42700A - G-25 antibiotic substance and method of preparation - Google Patents
G-25 antibiotic substance and method of preparationInfo
- Publication number
- IL42700A IL42700A IL42700A IL4270073A IL42700A IL 42700 A IL42700 A IL 42700A IL 42700 A IL42700 A IL 42700A IL 4270073 A IL4270073 A IL 4270073A IL 42700 A IL42700 A IL 42700A
- Authority
- IL
- Israel
- Prior art keywords
- acid addition
- pharmaceutically acceptable
- addition salt
- acceptable acid
- solvate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 21
- VIAXDDBFFSKHGA-UHFFFAOYSA-N Antibiotic G52 Natural products CNC1CC(N)C(OC2OCC(C)(O)C(NC)C2O)C(O)C1OC3OC(=CCC3N)CN VIAXDDBFFSKHGA-UHFFFAOYSA-N 0.000 title claims 9
- ARCVBMPERJRMKB-UHFFFAOYSA-N antibiotic g-52 Chemical compound O1C(CNC)=CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N ARCVBMPERJRMKB-UHFFFAOYSA-N 0.000 title claims 9
- 239000002253 acid Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 8
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 claims 6
- 229930192786 Sisomicin Natural products 0.000 claims 6
- 229960005456 sisomicin Drugs 0.000 claims 6
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 238000000855 fermentation Methods 0.000 claims 3
- 230000004151 fermentation Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 1
- 241000187720 Micromonospora zionensis Species 0.000 claims 1
- 238000000862 absorption spectrum Methods 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27183872A | 1972-07-14 | 1972-07-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42700A0 IL42700A0 (en) | 1973-10-25 |
| IL42700A true IL42700A (en) | 1976-07-30 |
Family
ID=23037307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42700A IL42700A (en) | 1972-07-14 | 1973-07-10 | G-25 antibiotic substance and method of preparation |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5713278B2 (en)) |
| AR (1) | AR199112A1 (en)) |
| AT (1) | ATA607973A (en)) |
| BE (1) | BE802185A (en)) |
| BG (1) | BG22409A3 (en)) |
| CA (1) | CA984774A (en)) |
| CH (1) | CH584754A5 (en)) |
| DD (2) | DD107483A5 (en)) |
| DE (1) | DE2334923A1 (en)) |
| DK (1) | DK131791C (en)) |
| FI (1) | FI50254C (en)) |
| FR (1) | FR2247220B1 (en)) |
| GB (1) | GB1424114A (en)) |
| HU (1) | HU175176B (en)) |
| IE (1) | IE38063B1 (en)) |
| IL (1) | IL42700A (en)) |
| LU (1) | LU67985A1 (en)) |
| NL (1) | NL7309610A (en)) |
| PH (1) | PH11419A (en)) |
| PL (1) | PL87638B1 (en)) |
| SE (1) | SE390541B (en)) |
| ZA (1) | ZA734694B (en)) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62150190U (en)) * | 1986-03-17 | 1987-09-22 | ||
| JPS6311876U (en)) * | 1986-07-09 | 1988-01-26 | ||
| JPS63112078U (en)) * | 1987-01-08 | 1988-07-19 |
-
1973
- 1973-07-06 CH CH993073A patent/CH584754A5/xx not_active IP Right Cessation
- 1973-07-10 FR FR7325226A patent/FR2247220B1/fr not_active Expired
- 1973-07-10 AT AT607973A patent/ATA607973A/de not_active Application Discontinuation
- 1973-07-10 IL IL42700A patent/IL42700A/en unknown
- 1973-07-10 SE SE7309696A patent/SE390541B/xx unknown
- 1973-07-10 CA CA176,036A patent/CA984774A/en not_active Expired
- 1973-07-10 NL NL7309610A patent/NL7309610A/xx unknown
- 1973-07-10 DK DK382873A patent/DK131791C/da active
- 1973-07-10 GB GB3271973A patent/GB1424114A/en not_active Expired
- 1973-07-10 DE DE19732334923 patent/DE2334923A1/de active Pending
- 1973-07-10 IE IE1171/73A patent/IE38063B1/xx unknown
- 1973-07-11 BE BE133342A patent/BE802185A/xx unknown
- 1973-07-11 JP JP7825173A patent/JPS5713278B2/ja not_active Expired
- 1973-07-11 FI FI732206A patent/FI50254C/fi active
- 1973-07-11 PH PH14815A patent/PH11419A/en unknown
- 1973-07-11 ZA ZA734694A patent/ZA734694B/xx unknown
- 1973-07-11 LU LU67985A patent/LU67985A1/xx unknown
- 1973-07-12 DD DD172234A patent/DD107483A5/xx unknown
- 1973-07-12 HU HU73SCHE438A patent/HU175176B/hu unknown
- 1973-07-12 PL PL1973164031A patent/PL87638B1/pl unknown
- 1973-07-12 DD DD179782*A patent/DD113169A5/xx unknown
- 1973-07-13 BG BG024094A patent/BG22409A3/xx unknown
-
1974
- 1974-07-11 AR AR249016A patent/AR199112A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| FI50254B (en)) | 1975-09-30 |
| IE38063B1 (en) | 1977-12-21 |
| FI50254C (fi) | 1976-01-12 |
| AU5797673A (en) | 1975-01-16 |
| ATA607973A (de) | 1977-11-15 |
| DK131791B (da) | 1975-09-01 |
| BG22409A3 (bg) | 1977-02-20 |
| CA984774A (en) | 1976-03-02 |
| PH11419A (en) | 1978-01-09 |
| JPS4955895A (en)) | 1974-05-30 |
| CH584754A5 (en)) | 1977-02-15 |
| LU67985A1 (en)) | 1973-09-13 |
| IE38063L (en) | 1974-01-14 |
| AR199112A1 (es) | 1974-08-08 |
| ZA734694B (en) | 1974-06-26 |
| SE390541B (sv) | 1976-12-27 |
| IL42700A0 (en) | 1973-10-25 |
| BE802185A (fr) | 1974-01-11 |
| JPS5713278B2 (en)) | 1982-03-16 |
| PL87638B1 (en)) | 1976-07-31 |
| FR2247220B1 (en)) | 1976-12-31 |
| FR2247220A1 (en)) | 1975-05-09 |
| DK131791C (da) | 1976-02-02 |
| DD107483A5 (en)) | 1974-08-05 |
| HU175176B (hu) | 1980-05-28 |
| NL7309610A (en)) | 1974-01-16 |
| DD113169A5 (en)) | 1975-05-20 |
| DE2334923A1 (de) | 1974-01-24 |
| GB1424114A (en) | 1976-02-11 |
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