IL41932A - Pyridine carboxylic acid esters of cycloalkenylphenyl-alkyl derivatives and their manufacture - Google Patents
Pyridine carboxylic acid esters of cycloalkenylphenyl-alkyl derivatives and their manufactureInfo
- Publication number
- IL41932A IL41932A IL41932A IL4193273A IL41932A IL 41932 A IL41932 A IL 41932A IL 41932 A IL41932 A IL 41932A IL 4193273 A IL4193273 A IL 4193273A IL 41932 A IL41932 A IL 41932A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- process according
- formula
- phenyl
- cyclohexen
- Prior art date
Links
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 26
- 238000000034 method Methods 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- -1 pyridinecarboxylic acid ester Chemical class 0.000 claims 4
- 150000008064 anhydrides Chemical class 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- HVMFHGSZDUOIGR-UHFFFAOYSA-N 2-[4-(cyclohexen-1-yl)phenyl]-1-propylpyridine-2-carboxylic acid Chemical compound CCCN1C=CC=CC1(C2=CC=C(C=C2)C3=CCCCC3)C(=O)O HVMFHGSZDUOIGR-UHFFFAOYSA-N 0.000 claims 1
- TUZDUZAMUJTDSK-UHFFFAOYSA-N CCCN1C=CC(C(O)=O)=CC1C(C=C1)=CC=C1C1=CCCCC1 Chemical compound CCCN1C=CC(C(O)=O)=CC1C(C=C1)=CC=C1C1=CCCCC1 TUZDUZAMUJTDSK-UHFFFAOYSA-N 0.000 claims 1
- 241000282320 Panthera leo Species 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
- C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH521372A CH571497A5 (en) | 1972-04-10 | 1972-04-10 | Pyridine-carboxylic acid aralkyl esters - anti-inflammatories, anti-phlogistics and peripheral analgesics |
| CH292073 | 1973-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL41932A true IL41932A (en) | 1976-08-31 |
Family
ID=25691731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41932A IL41932A (en) | 1972-04-10 | 1973-04-02 | Pyridine carboxylic acid esters of cycloalkenylphenyl-alkyl derivatives and their manufacture |
Country Status (13)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330838A1 (de) * | 1973-06-16 | 1975-01-09 | Thomae Gmbh Dr K | Neue carbonsaeureester von 3-(4biphenylyl)-1-butanolen und 3-(4-biphenylyl)2-buten-1-olen |
| JPS5344572A (en) * | 1976-09-30 | 1978-04-21 | Meiji Seika Kaisha Ltd | 5-alkoxy-picolic acid, its preparation and hypotensives containing the same |
| JPS5836660B2 (ja) * | 1978-12-13 | 1983-08-10 | 財団法人特殊無機材料研究所 | 延性に優れた高強度耐熱性分散強化型金属材料の製造方法 |
| FR2466458A1 (fr) * | 1979-09-27 | 1981-04-10 | Mathieu Andre | Nouveaux medicaments derives de l'eugenol |
| US4327218A (en) * | 1979-10-01 | 1982-04-27 | Stauffer Chemical Company | N-Aryl, 2-phenoxy nicotinamide compounds and the herbicidal use thereof |
| ITMI20010395A1 (it) | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
| DK1581474T3 (da) * | 2002-12-10 | 2008-12-08 | Dompe Spa | Chirale arylketoner i behandlingen af neutrofilt afhængige inflammatoriske sygdomme |
| AR092355A1 (es) * | 2012-07-24 | 2015-04-15 | Dow Agrosciences Llc | Fluoruros de fluoropicolinoilo y procesos para su preparacion |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557129A (en) * | 1968-05-14 | 1971-01-19 | Ortho Pharma Corp | Certain pyridoyl and furoyl esters of 2-(lower alkyl) - 3 - (lower alkayl)-4-aryl-3 or 4-cyclohexene carbinols |
| DE2222791A1 (de) * | 1971-05-19 | 1972-12-07 | Ciba Geigy Ag | Neue Pyridinessigsaeurederivate und Verfahren zu ihrer Herstellung |
-
1973
- 1973-03-29 SE SE7304444A patent/SE385883B/xx unknown
- 1973-04-02 AR AR247342A patent/AR197495A1/es active
- 1973-04-02 IL IL41932A patent/IL41932A/en unknown
- 1973-04-03 CA CA167,838A patent/CA998676A/en not_active Expired
- 1973-04-04 US US347931A patent/US3876648A/en not_active Expired - Lifetime
- 1973-04-04 DE DE2316851A patent/DE2316851A1/de active Pending
- 1973-04-05 FR FR7312273A patent/FR2182936B1/fr not_active Expired
- 1973-04-09 IE IE551/73A patent/IE37506B1/xx unknown
- 1973-04-09 DD DD170046A patent/DD105217A5/xx unknown
- 1973-04-09 GB GB1682173A patent/GB1393515A/en not_active Expired
- 1973-04-09 ES ES413489A patent/ES413489A1/es not_active Expired
- 1973-04-10 JP JP48040080A patent/JPS497285A/ja active Pending
- 1973-04-10 NL NL7305007A patent/NL7305007A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2316851A1 (de) | 1973-10-25 |
| AR197495A1 (es) | 1974-04-15 |
| NL7305007A (US20100223739A1-20100909-C00025.png) | 1973-10-12 |
| FR2182936A1 (US20100223739A1-20100909-C00025.png) | 1973-12-14 |
| US3876648A (en) | 1975-04-08 |
| IE37506B1 (en) | 1977-08-03 |
| SE385883B (sv) | 1976-07-26 |
| CA998676A (en) | 1976-10-19 |
| FR2182936B1 (US20100223739A1-20100909-C00025.png) | 1975-10-31 |
| DD105217A5 (US20100223739A1-20100909-C00025.png) | 1974-04-12 |
| IE37506L (en) | 1973-10-10 |
| JPS497285A (US20100223739A1-20100909-C00025.png) | 1974-01-22 |
| GB1393515A (en) | 1975-05-07 |
| ES413489A1 (es) | 1976-05-01 |
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