IL41798A - Pyrrolidylidene-,piperidylidene-and hexahydroazepinylidene-ureas and their preparation - Google Patents

Pyrrolidylidene-,piperidylidene-and hexahydroazepinylidene-ureas and their preparation

Info

Publication number
IL41798A
IL41798A IL7341798A IL4179873A IL41798A IL 41798 A IL41798 A IL 41798A IL 7341798 A IL7341798 A IL 7341798A IL 4179873 A IL4179873 A IL 4179873A IL 41798 A IL41798 A IL 41798A
Authority
IL
Israel
Prior art keywords
reacting
group
preparing
pyrrolidylidene
hydrogen
Prior art date
Application number
IL7341798A
Other versions
IL41798A0 (en
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Publication of IL41798A0 publication Critical patent/IL41798A0/en
Publication of IL41798A publication Critical patent/IL41798A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (1)

1. PROCESS CIA A process for preparing 1 chemical compounds selected from the group 2 consisting of pyrrolidylidene piperidylidene 3 hydroazepinylidene ureas having the and the therapeutically active acid addition salts n is the integer 2 or the group consisting 8 hydrogen and lo 9 is a member selected from the group consisting 10 of loweralkyl and benzyl 11 is member selected from the group consisting 12 hydrogen and and PROCESS CLAIMS Ar s a from the croup of and and and and trifluoro halophenyl and provided when said n is 2 or then said R is hydrogen and said is characterized by 6 reacting a compound of the formula 7 with a compound of the formula 8 erably i n a c PROCESS CLAIMS reacting a compound of the formula II with a compound of the formula 0 R2 preferably in a and if preparing a therapeutically active acid addition salt of the products of steps or A process for preparing according to claim characterized by reacting with phenylisocyanate A process for preparing phenylurea with A process for preparing urea according to claim characterized by reacting with CLAIMS 243 A process for preparing according to claim characterized reacting with fluorophenylisocyanate A process for preparing pyrrolidylidene according to claim characterized by reacting with A process for preparing according to claim by reacting A process for preparing pyrrolidylidene according to claim characterized by reacting with te A process for preparing according to claim characterized by reacting with A process for preparing pyrrolidylidene according to claim characterized by reacting with A process for preparing according characterized by reacting with A process for preparing according to claim characterized reacting with A process for preparing acc0rding to claim characterized by reacting with phenylisocyanate PROCES 243 A process for preparing according to claim characterized by reacting with methylphenylisocyanate A process for preparing according to claim characterized by reacting with A process for preparing according to claim characterized by reacting with A process for preparing according to claim characterized by reacting with process for preparing according to claim characterized by reacting with PRODUCT 19 Chemical selected from the group consisting of piperidylidene and hydroazepinylidene ureas having the PRODUCT CLAIMS Ar is a member selected from the group consisting of and and and and 20 21 trifluoro 22 halophenyl and 23 provided PRODUCT CLAIMS 243 is a selected from group i of hydrogen and 7 is a member selected from the group 8 loweralkyl and 9 a selected from the group consisting 10 of hydrogen and and 11 Ar is a member selected from the group consisting of and halpp enyl and t 15 and 19 arid 20 21 Chemical selected the consisting of pyrrolidylidene ureas having the and the therapeutically active acid addition salts wherein Ar is a member selected from the group consisting of and and and nit 22 A compound selected from the group consisting piperidylidene ureas having the r PRODUCT CLAIMS and the therapeutically active acid addition salts is lkyl is a from the group consisting of hydrogen and and Ar is a member selected from the group consistin of and and and and i halophenyl and A selected from the group consisting of hexahydroazepinylidene ureas havin and the is selected from the group consisting of hydrogen and and Ar is a member selected from the group consisting of and and cyanop and 24 25 26 27 28 pyrrolidylidene 4 32 pyrrolidylidene PRODUCT 33 34 35 36 40 243 PRODUCT CLAIMS 41 A central nervous system characterized by the fact that the active ingredient has the I 42 A process for preparing a compound of the formula substantially as hereinbefore and with reference to the accompanying 43 A compound of the formula I herein whenever prepared according to the process claimed in claim insufficientOCRQuality
IL7341798A 1972-03-17 1973-03-16 Pyrrolidylidene-,piperidylidene-and hexahydroazepinylidene-ureas and their preparation IL41798A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23581672A 1972-03-17 1972-03-17
US33584573A 1973-02-26 1973-02-26

Publications (2)

Publication Number Publication Date
IL41798A0 IL41798A0 (en) 1973-05-31
IL41798A true IL41798A (en) 1976-04-30

Family

ID=26929245

Family Applications (1)

Application Number Title Priority Date Filing Date
IL7341798A IL41798A (en) 1972-03-17 1973-03-16 Pyrrolidylidene-,piperidylidene-and hexahydroazepinylidene-ureas and their preparation

Country Status (12)

Country Link
AT (2) AT323191B (en)
CA (1) CA950464A (en)
CH (1) CH578539A5 (en)
CS (2) CS179412B2 (en)
DE (1) DE2313257A1 (en)
DK (1) DK136715B (en)
FI (1) FI56831C (en)
FR (1) FR2181826B1 (en)
GB (1) GB1414048A (en)
IL (1) IL41798A (en)
NL (1) NL7303723A (en)
NO (1) NO140136C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ183570A (en) * 1976-03-19 1979-06-08 Mcneilab Inc Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717648A (en) * 1970-10-21 1973-02-20 Sterling Drug Inc 1-phenyl-azacarbocyclic-2-imines

Also Published As

Publication number Publication date
NO140136B (en) 1979-04-02
FI56831C (en) 1980-04-10
CA950464A (en) 1974-07-02
NL7303723A (en) 1973-09-19
NO140136C (en) 1979-07-11
CH578539A5 (en) 1976-08-13
GB1414048A (en) 1975-11-12
CS179412B2 (en) 1977-10-31
DE2313257A1 (en) 1973-10-04
FI56831B (en) 1979-12-31
IL41798A0 (en) 1973-05-31
AT323191B (en) 1975-06-25
AT323194B (en) 1975-06-25
FR2181826A1 (en) 1973-12-07
DK136715C (en) 1978-04-24
CS179444B2 (en) 1977-10-31
DK136715B (en) 1977-11-14
FR2181826B1 (en) 1976-04-09

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