IL41630A - Quinolineacetic acid derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents
Quinolineacetic acid derivatives,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL41630A IL41630A IL41630A IL4163073A IL41630A IL 41630 A IL41630 A IL 41630A IL 41630 A IL41630 A IL 41630A IL 4163073 A IL4163073 A IL 4163073A IL 41630 A IL41630 A IL 41630A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- group
- process according
- compound
- methyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- FPDPFLYDDGYGKP-UHFFFAOYSA-N 2-quinolin-2-ylacetic acid Chemical class C1=CC=CC2=NC(CC(=O)O)=CC=C21 FPDPFLYDDGYGKP-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 35
- 238000000034 method Methods 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 150000004702 methyl esters Chemical class 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000007513 acids Chemical class 0.000 claims 3
- RPKKVRZEOYPXSH-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)quinolin-6-yl]acetic acid Chemical compound C1=CC2=CC(CC(=O)O)=CC=C2N=C1C1=CC=C(Cl)C=C1 RPKKVRZEOYPXSH-UHFFFAOYSA-N 0.000 claims 2
- ABARUQJDWXAIBS-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)quinolin-6-yl]acetic acid Chemical compound C1=CC2=CC(CC(=O)O)=CC=C2N=C1C1=CC=C(F)C=C1 ABARUQJDWXAIBS-UHFFFAOYSA-N 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- -1 thiocarbamoyl group Chemical group 0.000 claims 2
- SRTYGKKHBXKZON-UHFFFAOYSA-N 2-(2-phenylquinolin-6-yl)acetic acid Chemical compound C1=CC2=CC(CC(=O)O)=CC=C2N=C1C1=CC=CC=C1 SRTYGKKHBXKZON-UHFFFAOYSA-N 0.000 claims 1
- DDILQTXIQDFSPD-UHFFFAOYSA-N 2-(2-thiophen-2-ylquinolin-6-yl)acetic acid Chemical compound C1=CC2=CC(CC(=O)O)=CC=C2N=C1C1=CC=CS1 DDILQTXIQDFSPD-UHFFFAOYSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 150000001448 anilines Chemical class 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 150000004653 carbonic acids Chemical class 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002560 nitrile group Chemical group 0.000 claims 1
- 125000003431 oxalo group Chemical group 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Chemical Treatment Of Metals (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH354972A CH567477A5 (enrdf_load_html_response) | 1972-03-10 | 1972-03-10 | |
| CH123073 | 1973-01-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41630A0 IL41630A0 (en) | 1973-04-30 |
| IL41630A true IL41630A (en) | 1976-01-30 |
Family
ID=25687064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41630A IL41630A (en) | 1972-03-10 | 1973-02-27 | Quinolineacetic acid derivatives,their manufacture and pharmaceutical compositions containing them |
Country Status (8)
| Country | Link |
|---|---|
| DD (1) | DD105803A5 (enrdf_load_html_response) |
| DK (1) | DK138387B (enrdf_load_html_response) |
| ES (2) | ES412441A1 (enrdf_load_html_response) |
| FI (1) | FI51177C (enrdf_load_html_response) |
| HU (1) | HU166552B (enrdf_load_html_response) |
| IE (1) | IE37321B1 (enrdf_load_html_response) |
| IL (1) | IL41630A (enrdf_load_html_response) |
| NO (1) | NO140267C (enrdf_load_html_response) |
-
1973
- 1973-02-12 FI FI39873A patent/FI51177C/fi active
- 1973-02-26 IE IE29673A patent/IE37321B1/xx unknown
- 1973-02-27 IL IL41630A patent/IL41630A/en unknown
- 1973-03-07 NO NO92473A patent/NO140267C/no unknown
- 1973-03-08 ES ES412441A patent/ES412441A1/es not_active Expired
- 1973-03-09 DK DK130373A patent/DK138387B/da unknown
- 1973-03-09 DD DD16933473A patent/DD105803A5/xx unknown
- 1973-03-09 HU HUCI001349 patent/HU166552B/hu unknown
-
1975
- 1975-07-16 ES ES439490A patent/ES439490A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO140267C (no) | 1979-08-01 |
| IL41630A0 (en) | 1973-04-30 |
| IE37321B1 (en) | 1977-06-22 |
| HU166552B (enrdf_load_html_response) | 1975-04-28 |
| DK138387C (enrdf_load_html_response) | 1979-03-12 |
| NO140267B (no) | 1979-04-23 |
| DK138387B (da) | 1978-08-28 |
| FI51177B (enrdf_load_html_response) | 1976-08-02 |
| DD105803A5 (enrdf_load_html_response) | 1974-05-12 |
| FI51177C (fi) | 1976-11-10 |
| ES439490A1 (es) | 1977-06-01 |
| IE37321L (en) | 1973-09-10 |
| ES412441A1 (es) | 1976-05-01 |
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