IL41476A - Picolinic acid derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents
Picolinic acid derivatives,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL41476A IL41476A IL41476A IL4147673A IL41476A IL 41476 A IL41476 A IL 41476A IL 41476 A IL41476 A IL 41476A IL 4147673 A IL4147673 A IL 4147673A IL 41476 A IL41476 A IL 41476A
- Authority
- IL
- Israel
- Prior art keywords
- pyridine
- butyl
- compound
- methoxy
- amino
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 9
- 238000004519 manufacturing process Methods 0.000 title claims 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 28
- 238000000034 method Methods 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- -1 pyridine compound Chemical class 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 3
- CJCSPKMFHVPWAR-JTQLQIEISA-N alpha-methyl-L-dopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- QEEGJLSZBDISLG-UHFFFAOYSA-N 5-butyl-4-methoxypyridine-2-carboxylic acid Chemical compound CCCCC1=CN=C(C(O)=O)C=C1OC QEEGJLSZBDISLG-UHFFFAOYSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 159000000007 calcium salts Chemical class 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- WSRJWHWKBDHVGA-UHFFFAOYSA-N 5-butyl-4,6-dimethoxypyridine-2-carboxylic acid Chemical compound CCCCC1=C(OC)C=C(C(O)=O)N=C1OC WSRJWHWKBDHVGA-UHFFFAOYSA-N 0.000 claims 1
- PKZMJGHIEXFEHC-UHFFFAOYSA-N 5-butyl-4-methoxy-6-piperidin-1-ylpyridine-2-carboxylic acid Chemical compound CCCCC1=C(OC)C=C(C(O)=O)N=C1N1CCCCC1 PKZMJGHIEXFEHC-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000005237 alkyleneamino group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- ZUNWOYXJINYCNJ-UHFFFAOYSA-N methyl 5-butyl-4-chloro-6-oxo-1h-pyridine-2-carboxylate Chemical compound CCCCC1=C(Cl)C=C(C(=O)OC)N=C1O ZUNWOYXJINYCNJ-UHFFFAOYSA-N 0.000 claims 1
- QFAITDVDBDFACQ-UHFFFAOYSA-N methyl 5-butyl-6-chloro-4-piperidin-1-ylpyridine-2-carboxylate Chemical compound CCCCC1=C(Cl)N=C(C(=O)OC)C=C1N1CCCCC1 QFAITDVDBDFACQ-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000005504 styryl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH230172A CH570376A5 (OSRAM) | 1972-02-17 | 1972-02-17 | |
| CH1354372 | 1972-09-15 | ||
| CH1872972 | 1972-12-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41476A0 IL41476A0 (en) | 1973-04-30 |
| IL41476A true IL41476A (en) | 1976-06-30 |
Family
ID=27173606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41476A IL41476A (en) | 1972-02-17 | 1973-02-06 | Picolinic acid derivatives,their manufacture and pharmaceutical compositions containing them |
Country Status (9)
| Country | Link |
|---|---|
| AR (3) | AR204708A1 (OSRAM) |
| DD (1) | DD104977A5 (OSRAM) |
| EG (1) | EG10917A (OSRAM) |
| ES (1) | ES411657A1 (OSRAM) |
| HU (1) | HU171241B (OSRAM) |
| IE (1) | IE37260B1 (OSRAM) |
| IL (1) | IL41476A (OSRAM) |
| PH (1) | PH10009A (OSRAM) |
| RO (1) | RO62813A (OSRAM) |
-
1973
- 1973-01-01 AR AR25125873A patent/AR204708A1/es active
- 1973-02-06 IL IL41476A patent/IL41476A/en unknown
- 1973-02-06 IE IE18373A patent/IE37260B1/xx unknown
- 1973-02-13 RO RO7382573A patent/RO62813A/ro unknown
- 1973-02-13 PH PH14343*A patent/PH10009A/en unknown
- 1973-02-15 EG EG6173A patent/EG10917A/xx active
- 1973-02-15 DD DD16893973A patent/DD104977A5/xx unknown
- 1973-02-16 HU HU73CI00001343A patent/HU171241B/hu unknown
- 1973-03-15 ES ES411657A patent/ES411657A1/es not_active Expired
- 1973-11-29 AR AR25125773A patent/AR200160A1/es active
-
1974
- 1974-09-24 AR AR25571574A patent/AR202045A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| PH10009A (en) | 1976-07-13 |
| HU171241B (hu) | 1977-12-28 |
| IL41476A0 (en) | 1973-04-30 |
| AR200160A1 (es) | 1974-10-24 |
| DD104977A5 (OSRAM) | 1974-04-05 |
| RO62813A (fr) | 1977-11-15 |
| AR202045A1 (es) | 1975-05-09 |
| IE37260L (en) | 1973-08-17 |
| EG10917A (en) | 1976-08-31 |
| IE37260B1 (en) | 1977-06-08 |
| AR204708A1 (es) | 1976-02-27 |
| ES411657A1 (es) | 1977-03-01 |
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