IL39294A - Method of inducing infertility and inhibiting the growth of the prostate in male animals by 3,5-bis(substituted amino)-1,2,4-dithiazolium salts or 1,5-bis(substituted)-dithiobiurets - Google Patents
Method of inducing infertility and inhibiting the growth of the prostate in male animals by 3,5-bis(substituted amino)-1,2,4-dithiazolium salts or 1,5-bis(substituted)-dithiobiuretsInfo
- Publication number
- IL39294A IL39294A IL39294A IL3929472A IL39294A IL 39294 A IL39294 A IL 39294A IL 39294 A IL39294 A IL 39294A IL 3929472 A IL3929472 A IL 3929472A IL 39294 A IL39294 A IL 39294A
- Authority
- IL
- Israel
- Prior art keywords
- bis
- substituted
- prostate
- inhibiting
- growth
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims description 8
- -1 3,5-bis(substituted amino)-1,2,4-dithiazolium salts Chemical class 0.000 title claims description 7
- 238000000034 method Methods 0.000 title claims description 7
- 210000002307 prostate Anatomy 0.000 title claims description 7
- 230000002401 inhibitory effect Effects 0.000 title claims description 5
- 208000000509 infertility Diseases 0.000 title description 7
- 230000036512 infertility Effects 0.000 title description 7
- 231100000535 infertility Toxicity 0.000 title description 4
- 230000001939 inductive effect Effects 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 23
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 4
- 210000001625 seminal vesicle Anatomy 0.000 claims description 4
- 201000010653 vesiculitis Diseases 0.000 claims description 4
- 230000035558 fertility Effects 0.000 claims description 3
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 241000700159 Rattus Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000002054 antogonadotrophic effect Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 210000000918 epididymis Anatomy 0.000 description 2
- 201000010063 epididymitis Diseases 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000026234 pro-estrus Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000001741 seminiferous epithelium Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 206010024870 Loss of libido Diseases 0.000 description 1
- 241000257226 Muscidae Species 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- JIRRNZWTWJGJCT-UHFFFAOYSA-N carbamothioylthiourea Chemical compound NC(=S)NC(N)=S JIRRNZWTWJGJCT-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000002837 defoliant Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000002332 leydig cell Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13742671A | 1971-04-26 | 1971-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL39294A0 IL39294A0 (en) | 1972-06-28 |
| IL39294A true IL39294A (en) | 1974-11-29 |
Family
ID=22477382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL39294A IL39294A (en) | 1971-04-26 | 1972-04-25 | Method of inducing infertility and inhibiting the growth of the prostate in male animals by 3,5-bis(substituted amino)-1,2,4-dithiazolium salts or 1,5-bis(substituted)-dithiobiurets |
Country Status (7)
| Country | Link |
|---|---|
| AT (2) | AT321024B (de) |
| AU (1) | AU4144172A (de) |
| BE (1) | BE782641A (de) |
| DE (1) | DE2219992A1 (de) |
| GB (1) | GB1351412A (de) |
| IL (1) | IL39294A (de) |
| ZA (1) | ZA722822B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
| TW200640888A (en) * | 2005-02-11 | 2006-12-01 | Solvay Pharm Bv | [1,2,4]-dithiazoli (di) ne derivatives, inducers of glutha-thione-S-transferase and NADPH quinone oxido-reduc-tase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular |
| US7678789B2 (en) | 2005-02-11 | 2010-03-16 | Solvay Pharmaceuticals B.V. | [1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular |
-
1972
- 1972-04-21 AU AU41441/72A patent/AU4144172A/en not_active Expired
- 1972-04-24 DE DE19722219992 patent/DE2219992A1/de active Pending
- 1972-04-24 GB GB1885772A patent/GB1351412A/en not_active Expired
- 1972-04-25 IL IL39294A patent/IL39294A/en unknown
- 1972-04-25 BE BE782641A patent/BE782641A/xx unknown
- 1972-04-26 AT AT707273A patent/AT321024B/de not_active IP Right Cessation
- 1972-04-26 ZA ZA722822A patent/ZA722822B/xx unknown
- 1972-04-26 AT AT367272A patent/AT315564B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2219992A1 (de) | 1972-11-09 |
| AU4144172A (en) | 1973-10-25 |
| IL39294A0 (en) | 1972-06-28 |
| AT321024B (de) | 1975-03-10 |
| AT315564B (de) | 1974-05-27 |
| ZA722822B (en) | 1973-12-19 |
| GB1351412A (en) | 1974-05-01 |
| BE782641A (fr) | 1972-10-25 |
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