IL39147A - Amino alcohols derived from ortho trans-hydroxycinnamic acids,their esters and their amides,preparation thereof and pharmaceutical compositions containing them - Google Patents
Amino alcohols derived from ortho trans-hydroxycinnamic acids,their esters and their amides,preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- IL39147A IL39147A IL39147A IL3914772A IL39147A IL 39147 A IL39147 A IL 39147A IL 39147 A IL39147 A IL 39147A IL 3914772 A IL3914772 A IL 3914772A IL 39147 A IL39147 A IL 39147A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- alkoxy
- condensation
- same
- preparing compounds
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 5
- 150000002148 esters Chemical class 0.000 title claims 2
- 150000001408 amides Chemical class 0.000 title 1
- 150000001414 amino alcohols Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 10
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000002253 acid Substances 0.000 claims abstract 4
- 238000009833 condensation Methods 0.000 claims abstract 4
- 230000005494 condensation Effects 0.000 claims abstract 4
- 125000002431 aminoalkoxy group Chemical group 0.000 claims abstract 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000007513 acids Chemical class 0.000 claims abstract 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 239000001828 Gelatine Substances 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 1
- 244000061456 Solanum tuberosum Species 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- AMEDKBHURXXSQO-UHFFFAOYSA-N azonous acid Chemical group ONO AMEDKBHURXXSQO-UHFFFAOYSA-N 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- -1 Amino alcohol ethers Chemical class 0.000 abstract 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XXRJDOQENVGLJT-UHFFFAOYSA-N 6-bromochromen-2-one Chemical compound O1C(=O)C=CC2=CC(Br)=CC=C21 XXRJDOQENVGLJT-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100533387 Homo sapiens SCGB1D1 gene Proteins 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 102100028659 Secretoglobin family 1D member 1 Human genes 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- BRKHPXXMZRQYHR-GORDUTHDSA-N methyl (e)-3-(5-bromo-2-hydroxyphenyl)prop-2-enoate Chemical compound COC(=O)\C=C\C1=CC(Br)=CC=C1O BRKHPXXMZRQYHR-GORDUTHDSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- PMOWTIHVNWZYFI-AATRIKPKSA-N trans-2-coumaric acid Chemical class OC(=O)\C=C\C1=CC=CC=C1O PMOWTIHVNWZYFI-AATRIKPKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7112668A FR2132570B1 (nl) | 1971-04-09 | 1971-04-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL39147A0 IL39147A0 (en) | 1972-06-28 |
IL39147A true IL39147A (en) | 1976-12-31 |
Family
ID=9075074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL39147A IL39147A (en) | 1971-04-09 | 1972-04-06 | Amino alcohols derived from ortho trans-hydroxycinnamic acids,their esters and their amides,preparation thereof and pharmaceutical compositions containing them |
Country Status (26)
Country | Link |
---|---|
US (1) | US3828095A (nl) |
JP (1) | JPS5544738B1 (nl) |
AR (1) | AR192925A1 (nl) |
AT (1) | AT315151B (nl) |
AU (1) | AU463651B2 (nl) |
BE (1) | BE781805A (nl) |
BR (1) | BR7202015D0 (nl) |
CA (1) | CA999010A (nl) |
CH (1) | CH551942A (nl) |
CS (1) | CS171256B2 (nl) |
DD (1) | DD100459A5 (nl) |
DE (1) | DE2216537C2 (nl) |
ES (1) | ES401500A1 (nl) |
FR (1) | FR2132570B1 (nl) |
GB (1) | GB1358803A (nl) |
HU (1) | HU164931B (nl) |
IE (1) | IE36247B1 (nl) |
IL (1) | IL39147A (nl) |
IT (1) | IT998066B (nl) |
NL (1) | NL176453C (nl) |
NO (1) | NO139169C (nl) |
OA (1) | OA03987A (nl) |
SE (1) | SE385692B (nl) |
SU (1) | SU448639A3 (nl) |
YU (1) | YU35102B (nl) |
ZA (1) | ZA722318B (nl) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2623314C2 (de) * | 1976-05-25 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
DE2818765A1 (de) * | 1978-04-28 | 1979-11-08 | Basf Ag | Aminoderivate des 2-methyl-5-(2-hydroxystyrol)-1,3,4-thiadiazols |
CA1133494A (en) * | 1978-07-05 | 1982-10-12 | Erich Cohnen | Substituted 4-aryl-2,5-dihydro-furane- 2-ones and 4-aryl-1,5-dihydro-2h-pyrrole-2-ones and method of their production |
DE3062216D1 (en) * | 1979-09-06 | 1983-04-07 | Beecham Group Plc | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them |
SE8004087L (sv) | 1980-06-02 | 1981-12-03 | Haessle Ab | Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ... |
SE8004088L (sv) * | 1980-06-02 | 1981-12-03 | Haessle Ab | Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ... |
US4454154A (en) * | 1981-06-23 | 1984-06-12 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
ZA827646B (en) * | 1981-11-12 | 1983-08-31 | American Hospital Supply Corp | Esters of aryloxypropanolamine derivatives |
US4508725A (en) * | 1982-12-22 | 1985-04-02 | American Hospital Supply Corporation | Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives |
US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
US5232948A (en) * | 1990-09-10 | 1993-08-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity |
EP3311480B1 (en) | 2015-06-16 | 2020-02-12 | Danfoss Editron Oy | Method and arrangement for adjusting the magnetization of a permanent magnet machine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660230A (en) * | 1968-11-26 | 1972-05-02 | Gen Electric | Nuclear reactor control system |
CA945172A (en) * | 1969-02-21 | 1974-04-09 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
-
1971
- 1971-04-09 FR FR7112668A patent/FR2132570B1/fr not_active Expired
-
1972
- 1972-03-23 YU YU771/72A patent/YU35102B/xx unknown
- 1972-03-29 OA OA54528A patent/OA03987A/xx unknown
- 1972-03-30 IE IE423/72A patent/IE36247B1/xx unknown
- 1972-04-04 NO NO1128/72A patent/NO139169C/no unknown
- 1972-04-04 SE SE7204266A patent/SE385692B/xx unknown
- 1972-04-05 US US00241381A patent/US3828095A/en not_active Expired - Lifetime
- 1972-04-06 BR BR722015A patent/BR7202015D0/pt unknown
- 1972-04-06 IL IL39147A patent/IL39147A/en unknown
- 1972-04-06 CS CS2304A patent/CS171256B2/cs unknown
- 1972-04-06 ES ES401500A patent/ES401500A1/es not_active Expired
- 1972-04-06 GB GB1595072A patent/GB1358803A/en not_active Expired
- 1972-04-06 JP JP3396972A patent/JPS5544738B1/ja active Pending
- 1972-04-06 AU AU40818/72A patent/AU463651B2/en not_active Expired
- 1972-04-06 DE DE2216537A patent/DE2216537C2/de not_active Expired
- 1972-04-06 CA CA139,108A patent/CA999010A/en not_active Expired
- 1972-04-07 SU SU1772371A patent/SU448639A3/ru active
- 1972-04-07 BE BE116056A patent/BE781805A/xx not_active IP Right Cessation
- 1972-04-07 IT IT22835/72A patent/IT998066B/it active
- 1972-04-07 ZA ZA722318A patent/ZA722318B/xx unknown
- 1972-04-07 NL NLAANVRAGE7204726,A patent/NL176453C/nl not_active IP Right Cessation
- 1972-04-07 CH CH516072A patent/CH551942A/fr not_active IP Right Cessation
- 1972-04-08 HU HULI227A patent/HU164931B/hu unknown
- 1972-04-10 DD DD162185A patent/DD100459A5/xx unknown
- 1972-04-10 AT AT308272A patent/AT315151B/de not_active IP Right Cessation
- 1972-04-10 AR AR241388A patent/AR192925A1/es active
Also Published As
Publication number | Publication date |
---|---|
OA03987A (fr) | 1979-09-15 |
NO139169C (no) | 1979-01-31 |
GB1358803A (en) | 1974-07-03 |
US3828095A (en) | 1974-08-06 |
DD100459A5 (nl) | 1973-09-20 |
FR2132570B1 (nl) | 1974-08-02 |
NL176453B (nl) | 1984-11-16 |
SU448639A3 (ru) | 1974-10-30 |
IL39147A0 (en) | 1972-06-28 |
ZA722318B (en) | 1972-12-27 |
NO139169B (no) | 1978-10-09 |
FR2132570A1 (nl) | 1972-11-24 |
AU463651B2 (en) | 1975-07-16 |
CA999010A (en) | 1976-10-26 |
ES401500A1 (es) | 1975-09-16 |
BE781805A (fr) | 1972-10-09 |
DE2216537C2 (de) | 1984-08-02 |
IE36247B1 (en) | 1976-09-15 |
BR7202015D0 (pt) | 1975-02-12 |
IT998066B (it) | 1976-01-20 |
AT315151B (de) | 1974-05-10 |
NL176453C (nl) | 1985-04-16 |
NL7204726A (nl) | 1972-10-11 |
SE385692B (sv) | 1976-07-19 |
DE2216537A1 (de) | 1972-10-19 |
CH551942A (fr) | 1974-07-31 |
HU164931B (nl) | 1974-05-28 |
AU4081872A (en) | 1973-10-11 |
JPS5544738B1 (nl) | 1980-11-13 |
YU35102B (en) | 1980-09-25 |
CS171256B2 (nl) | 1976-10-29 |
AR192925A1 (es) | 1973-03-21 |
YU77172A (en) | 1980-03-15 |
IE36247L (en) | 1972-10-09 |
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