IL39079A - 16-loweralkyl and 16,16-diloweralkyl prostaglandins of the a2,b2,e2,and f2 types and process for making them - Google Patents
16-loweralkyl and 16,16-diloweralkyl prostaglandins of the a2,b2,e2,and f2 types and process for making themInfo
- Publication number
- IL39079A IL39079A IL39079A IL3907972A IL39079A IL 39079 A IL39079 A IL 39079A IL 39079 A IL39079 A IL 39079A IL 3907972 A IL3907972 A IL 3907972A IL 39079 A IL39079 A IL 39079A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- methyl
- compound
- formula
- racemic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 13
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 45
- 229910052739 hydrogen Inorganic materials 0.000 claims 45
- 239000001257 hydrogen Substances 0.000 claims 45
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 24
- 150000002431 hydrogen Chemical class 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 230000003287 optical effect Effects 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 101150052863 THY1 gene Proteins 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 229960002986 dinoprostone Drugs 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical group [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- PRFXRIUZNKLRHM-UHFFFAOYSA-N l-prostaglandin B2 Natural products CCCCCC(O)C=CC1=C(CC=CCCCC(O)=O)C(=O)CC1 PRFXRIUZNKLRHM-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 1
- NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 claims 1
- -1 tetrahydropyranyl oxy groups Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13334271A | 1971-04-12 | 1971-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL39079A0 IL39079A0 (en) | 1972-05-30 |
| IL39079A true IL39079A (en) | 1976-08-31 |
Family
ID=22458141
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL39079A IL39079A (en) | 1971-04-12 | 1972-03-26 | 16-loweralkyl and 16,16-diloweralkyl prostaglandins of the a2,b2,e2,and f2 types and process for making them |
| IL4715172A IL47151A (en) | 1971-04-12 | 1972-03-26 | 5alpha-hydroxy-2beta-(3alpha-(hydroxy or tetrahydropyranyloxy)-trans-1-octenyl)-1alpha-cyclopentane acetic acid or aldehyde ypsilon-lactone or ypsilon-lactol derivatives and their preparation |
| IL4715072A IL47150A (en) | 1971-04-12 | 1972-03-26 | 3alpha-benzoyloxy-5alpha-hydroxy-2beta-(trans-1-octenyl)-1alpha-cyclopentane acetic acid ypsilon-lactone derivatives and process for their preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL4715172A IL47151A (en) | 1971-04-12 | 1972-03-26 | 5alpha-hydroxy-2beta-(3alpha-(hydroxy or tetrahydropyranyloxy)-trans-1-octenyl)-1alpha-cyclopentane acetic acid or aldehyde ypsilon-lactone or ypsilon-lactol derivatives and their preparation |
| IL4715072A IL47150A (en) | 1971-04-12 | 1972-03-26 | 3alpha-benzoyloxy-5alpha-hydroxy-2beta-(trans-1-octenyl)-1alpha-cyclopentane acetic acid ypsilon-lactone derivatives and process for their preparation |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5314551B1 (enrdf_load_html_response) |
| AR (2) | AR194589A1 (enrdf_load_html_response) |
| ES (1) | ES401665A1 (enrdf_load_html_response) |
| FI (1) | FI54293C (enrdf_load_html_response) |
| HU (2) | HU165856B (enrdf_load_html_response) |
| IL (3) | IL39079A (enrdf_load_html_response) |
| NO (3) | NO135936C (enrdf_load_html_response) |
| PH (1) | PH10946A (enrdf_load_html_response) |
| PL (2) | PL96861B1 (enrdf_load_html_response) |
| SU (1) | SU628814A3 (enrdf_load_html_response) |
| ZA (1) | ZA721936B (enrdf_load_html_response) |
-
1972
- 1972-03-21 ZA ZA721936A patent/ZA721936B/xx unknown
- 1972-03-26 IL IL39079A patent/IL39079A/en unknown
- 1972-03-26 IL IL4715172A patent/IL47151A/en unknown
- 1972-03-26 IL IL4715072A patent/IL47150A/en unknown
- 1972-04-03 PH PH13409A patent/PH10946A/en unknown
- 1972-04-05 JP JP3358872A patent/JPS5314551B1/ja active Pending
- 1972-04-06 AR AR24133772A patent/AR194589A1/es active
- 1972-04-10 PL PL15464272A patent/PL96861B1/pl unknown
- 1972-04-10 PL PL18399072A patent/PL96666B1/pl unknown
- 1972-04-11 ES ES401665A patent/ES401665A1/es not_active Expired
- 1972-04-11 HU HUUO000075 patent/HU165856B/hu unknown
- 1972-04-11 FI FI101772A patent/FI54293C/fi active
- 1972-04-11 HU HUUO000081 patent/HU166656B/hu unknown
- 1972-04-11 NO NO122772A patent/NO135936C/no unknown
- 1972-08-21 SU SU721821458A patent/SU628814A3/ru active
- 1972-11-27 NO NO434172A patent/NO138252C/no unknown
- 1972-11-27 NO NO434272A patent/NO140423C/no unknown
-
1973
- 1973-02-27 AR AR24682173A patent/AR194784A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| SU439087A3 (enrdf_load_html_response) | 1974-08-05 |
| ES401665A1 (es) | 1975-03-01 |
| IL47150A (en) | 1976-08-31 |
| PL96666B1 (pl) | 1978-01-31 |
| NO135936C (enrdf_load_html_response) | 1977-06-29 |
| FI54293B (fi) | 1978-07-31 |
| IL47151A (en) | 1976-08-31 |
| FI54293C (fi) | 1978-11-10 |
| PH10946A (en) | 1977-10-05 |
| AR194589A1 (es) | 1973-07-31 |
| ZA721936B (en) | 1973-01-31 |
| NO138252C (no) | 1978-08-02 |
| NO140423C (no) | 1979-08-29 |
| NO138252B (no) | 1978-04-24 |
| SU628814A3 (ru) | 1978-10-15 |
| AR194784A1 (es) | 1973-08-14 |
| JPS5314551B1 (enrdf_load_html_response) | 1978-05-18 |
| HU165856B (enrdf_load_html_response) | 1974-11-28 |
| IL39079A0 (en) | 1972-05-30 |
| PL96861B1 (pl) | 1978-01-31 |
| HU166656B (enrdf_load_html_response) | 1975-04-28 |
| NO135936B (enrdf_load_html_response) | 1977-03-21 |
| NO140423B (no) | 1979-05-21 |
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