IL31374A - Preparation of pleuromutilin and its use in animal feeds - Google Patents
Preparation of pleuromutilin and its use in animal feedsInfo
- Publication number
- IL31374A IL31374A IL31374A IL3137465A IL31374A IL 31374 A IL31374 A IL 31374A IL 31374 A IL31374 A IL 31374A IL 3137465 A IL3137465 A IL 3137465A IL 31374 A IL31374 A IL 31374A
- Authority
- IL
- Israel
- Prior art keywords
- pleuromutilin
- feed
- antibiotic
- animal
- feed supplement
- Prior art date
Links
- ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title claims description 31
- ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 title claims description 28
- 241001465754 Metazoa Species 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title description 2
- 230000003115 biocidal effect Effects 0.000 claims description 24
- 239000006052 feed supplement Substances 0.000 claims description 14
- 235000015097 nutrients Nutrition 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- OBUUFWIMEGVAQS-UHFFFAOYSA-N Pleuromutenol Natural products CC1C(O)C(C)(C=C)CC(O)C2(C)C(C)CCC31C2C(=O)CC3 OBUUFWIMEGVAQS-UHFFFAOYSA-N 0.000 claims 1
- STZYTFJPGGDRJD-NHUWBDDWSA-N retapamulin Chemical compound C([C@H]([C@@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CS[C@@H]3C[C@H]4CC[C@H](N4C)C3)C)C[C@]32[C@H]1C(=O)CC3 STZYTFJPGGDRJD-NHUWBDDWSA-N 0.000 claims 1
- 229960002771 retapamulin Drugs 0.000 claims 1
- 238000000855 fermentation Methods 0.000 description 8
- 230000004151 fermentation Effects 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XIWJLPHQDBDOAN-UHFFFAOYSA-N 2,3,5,6-tetrachloro-4-methoxyphenol Chemical compound COC1=C(Cl)C(Cl)=C(O)C(Cl)=C1Cl XIWJLPHQDBDOAN-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 241001237959 Clitopilus Species 0.000 description 2
- 235000019733 Fish meal Nutrition 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 2
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HIUCKCDFIJDCPR-HJWRWDBZSA-N (z)-undec-3-en-5,7,10-triynoic acid Chemical compound OC(=O)C\C=C/C#CC#CCC#C HIUCKCDFIJDCPR-HJWRWDBZSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000222485 Agaricales Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- 239000005996 Blood meal Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241001459693 Dipterocarpus zeylanicus Species 0.000 description 1
- 241000255582 Drosophilidae Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000364057 Peoria Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000006050 antibiotic feed supplement Substances 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- GBSAGTNCIUWLCF-UHFFFAOYSA-N butyl acetate;propan-2-one Chemical compound CC(C)=O.CCCCOC(C)=O GBSAGTNCIUWLCF-UHFFFAOYSA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- -1 methylisobutylke one Chemical compound 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT340364A AT250770B (de) | 1964-04-17 | 1964-04-17 | Futtermittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL31374A true IL31374A (en) | 1969-05-28 |
Family
ID=3549996
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL31374A IL31374A (en) | 1964-04-17 | 1965-04-07 | Preparation of pleuromutilin and its use in animal feeds |
| IL23314A IL23314A (en) | 1964-04-17 | 1965-04-07 | Esters of the antibiotic pleuro-mutilin,their production and animal feed supplement containing same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL23314A IL23314A (en) | 1964-04-17 | 1965-04-07 | Esters of the antibiotic pleuro-mutilin,their production and animal feed supplement containing same |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JPS4916631B1 (de) |
| AT (1) | AT250770B (de) |
| DE (1) | DE1249657B (de) |
| DK (2) | DK135973B (de) |
| ES (1) | ES311866A1 (de) |
| GB (2) | GB1111009A (de) |
| IL (2) | IL31374A (de) |
| NL (3) | NL6504695A (de) |
| SE (3) | SE354482B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3949079A (en) * | 1964-04-17 | 1976-04-06 | Biochemie Ges.M.B.H. | Antibiotic derivatives |
| US4041175A (en) | 1974-05-13 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Use of pleuromutilin for the treatment of swine dysentery |
| US4129721A (en) * | 1977-12-08 | 1978-12-12 | Eli Lilly And Company | A-40104 antibiotics and process for production thereof |
| JPS55113645U (de) * | 1979-01-31 | 1980-08-11 | ||
| BG64840B1 (bg) * | 2001-04-09 | 2006-06-30 | "Балканфарма-Разград" АД | Метод за получаване на плеуромутилин |
| US11168049B1 (en) * | 2020-12-19 | 2021-11-09 | Xi'an Taikomed Pharmaceutical Technology Co., Ltd. | Pleuromulin tretinoin ester with antibacterial activity and a method of preparing the same |
-
0
- DE DENDAT1249657D patent/DE1249657B/de active Pending
-
1964
- 1964-04-17 AT AT340364A patent/AT250770B/de active
-
1965
- 1965-04-07 IL IL31374A patent/IL31374A/en unknown
- 1965-04-07 IL IL23314A patent/IL23314A/en unknown
- 1965-04-09 SE SE10224/69A patent/SE354482B/xx unknown
- 1965-04-09 SE SE4674/65A patent/SE322405B/xx unknown
- 1965-04-09 SE SE10225/69A patent/SE362417B/xx unknown
- 1965-04-12 DK DK184965AA patent/DK135973B/da unknown
- 1965-04-13 NL NL6504695A patent/NL6504695A/xx unknown
- 1965-04-14 ES ES0311866A patent/ES311866A1/es not_active Expired
- 1965-04-14 GB GB16059/65A patent/GB1111009A/en not_active Expired
- 1965-04-14 GB GB56203/67A patent/GB1111010A/en not_active Expired
-
1967
- 1967-10-31 JP JP42070208A patent/JPS4916631B1/ja active Pending
-
1969
- 1969-07-18 NL NL6911082A patent/NL6911082A/xx unknown
- 1969-07-18 NL NL6911083A patent/NL6911083A/xx unknown
-
1971
- 1971-08-13 DK DK396671AA patent/DK127192B/da unknown
- 1971-12-03 JP JP46098209A patent/JPS5026540B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SE354482B (de) | 1973-03-12 |
| IL23314A (en) | 1969-04-30 |
| ES311866A1 (es) | 1965-07-16 |
| SE322405B (de) | 1970-04-06 |
| DE1249657B (de) | |
| DK135973B (da) | 1977-07-25 |
| JPS5026540B1 (de) | 1975-09-01 |
| GB1111010A (en) | 1968-04-24 |
| AT250770B (de) | 1966-11-25 |
| JPS4916631B1 (de) | 1974-04-23 |
| DK135973C (de) | 1977-12-27 |
| GB1111009A (en) | 1968-04-24 |
| NL6911083A (de) | 1969-10-27 |
| NL6911082A (de) | 1969-10-27 |
| NL6504695A (de) | 1965-10-18 |
| SE362417B (de) | 1973-12-10 |
| DK127192B (da) | 1973-10-01 |
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