IL312012A - Compositions and methods for the treatment of opioid overdose - Google Patents

Compositions and methods for the treatment of opioid overdose

Info

Publication number
IL312012A
IL312012A IL312012A IL31201224A IL312012A IL 312012 A IL312012 A IL 312012A IL 312012 A IL312012 A IL 312012A IL 31201224 A IL31201224 A IL 31201224A IL 312012 A IL312012 A IL 312012A
Authority
IL
Israel
Prior art keywords
nalmefene
opioid
formulation
administered
therapeutically effective
Prior art date
Application number
IL312012A
Other languages
English (en)
Hebrew (he)
Original Assignee
Opiant Pharmaceuticals Inc
Aegis Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62146061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL312012(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opiant Pharmaceuticals Inc, Aegis Therapeutics Llc filed Critical Opiant Pharmaceuticals Inc
Publication of IL312012A publication Critical patent/IL312012A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Addiction (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL312012A 2016-11-18 2017-11-09 Compositions and methods for the treatment of opioid overdose IL312012A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662424378P 2016-11-18 2016-11-18
PCT/US2017/060964 WO2018093666A1 (en) 2016-11-18 2017-11-09 Compositions and methods for the treatment of opioid overdose

Publications (1)

Publication Number Publication Date
IL312012A true IL312012A (en) 2024-06-01

Family

ID=62146061

Family Applications (2)

Application Number Title Priority Date Filing Date
IL312012A IL312012A (en) 2016-11-18 2017-11-09 Compositions and methods for the treatment of opioid overdose
IL266674A IL266674B2 (en) 2016-11-18 2017-11-09 Compositions, devices and methods of using intranasal nalmefene and dodecyl maltoside for treatment of opioid overdose

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL266674A IL266674B2 (en) 2016-11-18 2017-11-09 Compositions, devices and methods of using intranasal nalmefene and dodecyl maltoside for treatment of opioid overdose

Country Status (9)

Country Link
US (3) US11458091B2 (cg-RX-API-DMAC10.html)
EP (1) EP3541386A4 (cg-RX-API-DMAC10.html)
JP (2) JP7312698B2 (cg-RX-API-DMAC10.html)
CN (1) CN110139651A (cg-RX-API-DMAC10.html)
AU (2) AU2017360910B2 (cg-RX-API-DMAC10.html)
CA (1) CA3044221A1 (cg-RX-API-DMAC10.html)
IL (2) IL312012A (cg-RX-API-DMAC10.html)
RU (1) RU2769397C2 (cg-RX-API-DMAC10.html)
WO (1) WO2018093666A1 (cg-RX-API-DMAC10.html)

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US20210220346A1 (en) * 2018-05-17 2021-07-22 Aegis Therapeutics Llc Formulations and methods for the prevention of opioid overdose
WO2019231993A1 (en) * 2018-06-01 2019-12-05 Purdue Pharma L.P. Compositions and methods for opioid overdose rescue
US11865112B2 (en) 2018-11-06 2024-01-09 Purdue Pharma L.P. Compositions and methods for opioid antagonist delivery
US20210401827A1 (en) * 2018-11-07 2021-12-30 Opiant Pharmaceuticals, Inc. Methods, parenteral pharmaceutical formulations, and devices for the prevention of opioid overdose
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CA3167312A1 (en) * 2020-02-07 2021-08-12 Stephen J. Lewis Compositions and methods for attenuating opioid induced cardio and/or respiratory depression
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WO2024222920A1 (zh) * 2023-04-28 2024-10-31 成都苑东生物制药股份有限公司 一种用于鼻内给药的药物制剂及其制备方法
WO2025255416A1 (en) * 2024-06-05 2025-12-11 TMTRx, Inc. Fentanyl and fentanyl analogue overdose reversal

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Also Published As

Publication number Publication date
US20200060967A1 (en) 2020-02-27
IL266674B1 (en) 2024-05-01
IL266674A (en) 2019-07-31
AU2017360910B2 (en) 2023-11-23
WO2018093666A1 (en) 2018-05-24
JP7312698B2 (ja) 2023-07-21
IL266674B2 (en) 2024-09-01
EP3541386A4 (en) 2020-05-27
CN110139651A (zh) 2019-08-16
AU2024201047A1 (en) 2024-03-14
US20220387306A1 (en) 2022-12-08
JP2023140359A (ja) 2023-10-04
US20250127712A1 (en) 2025-04-24
RU2019118465A3 (cg-RX-API-DMAC10.html) 2021-03-04
JP7730443B2 (ja) 2025-08-28
AU2017360910A1 (en) 2019-05-30
EP3541386A1 (en) 2019-09-25
CA3044221A1 (en) 2018-05-24
JP2019534315A (ja) 2019-11-28
RU2019118465A (ru) 2020-12-18
US11458091B2 (en) 2022-10-04
RU2769397C2 (ru) 2022-03-31

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