IL308397A - אגוניסטים של קולטן פפטיד 1 דמויי גלוקגון מאקרוציקליים - Google Patents
אגוניסטים של קולטן פפטיד 1 דמויי גלוקגון מאקרוציקלייםInfo
- Publication number
- IL308397A IL308397A IL308397A IL30839723A IL308397A IL 308397 A IL308397 A IL 308397A IL 308397 A IL308397 A IL 308397A IL 30839723 A IL30839723 A IL 30839723A IL 308397 A IL308397 A IL 308397A
- Authority
- IL
- Israel
- Prior art keywords
- macrocyclic
- glucagon
- peptide
- receptor agonists
- agonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163191034P | 2021-05-20 | 2021-05-20 | |
| US202163254564P | 2021-10-12 | 2021-10-12 | |
| EP21383172 | 2021-12-21 | ||
| PCT/US2022/029958 WO2022246019A1 (en) | 2021-05-20 | 2022-05-19 | Macrocyclic glucagon-like peptide 1 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL308397A true IL308397A (he) | 2024-01-01 |
Family
ID=82016585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL308397A IL308397A (he) | 2021-05-20 | 2022-05-19 | אגוניסטים של קולטן פפטיד 1 דמויי גלוקגון מאקרוציקליים |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4341255A1 (he) |
| JP (1) | JP7703691B2 (he) |
| KR (1) | KR20230173166A (he) |
| AU (1) | AU2022275931B2 (he) |
| BR (1) | BR112023022851A2 (he) |
| CA (1) | CA3218345A1 (he) |
| IL (1) | IL308397A (he) |
| MX (1) | MX2023013717A (he) |
| TW (1) | TWI843104B (he) |
| WO (1) | WO2022246019A1 (he) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL4408840T3 (pl) | 2021-09-27 | 2025-12-22 | Terns Pharmaceuticals, Inc. | Kwasy benzoimidazolokarboksylowe jako agoniści glp-1r |
| WO2023076237A1 (en) | 2021-10-25 | 2023-05-04 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| PE20250741A1 (es) | 2022-02-23 | 2025-03-13 | Terns Pharmaceuticals Inc | Compuestos como agonistas de glp-1r |
| EP4592285A1 (en) | 2022-09-22 | 2025-07-30 | Shionogi & Co., Ltd. | Fused ring compound having glp-1 receptor agonist effect |
| AU2023377707A1 (en) * | 2022-11-11 | 2025-05-15 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
| KR20250166323A (ko) | 2023-04-07 | 2025-11-27 | 테른스 파마슈티칼스, 인크. | 간 장애 또는 심장대사 질환의 치료에 사용하기 위한 thr베타 효현제 및 glp-1r 효현제를 포함하는 조합 |
| WO2025057134A2 (en) | 2023-09-14 | 2025-03-20 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| US12291530B1 (en) | 2023-11-24 | 2025-05-06 | Ascletis Pharma (China) Co., Limited | GLP-1R agonist and therapeutic method thereof |
| WO2025158275A1 (en) | 2024-01-24 | 2025-07-31 | Pfizer Inc. | Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds |
| WO2025189141A1 (en) | 2024-03-08 | 2025-09-12 | Annapurna Bio, Inc. | Methods for treating obesity and increasing weight loss |
| CN119219759A (zh) * | 2024-10-22 | 2024-12-31 | 浙江工业大学 | 一种双水相萃取耦合反相柱层析分离纯化发酵液中glp-1类似物的方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3555064T (lt) * | 2016-12-16 | 2023-01-10 | Pfizer Inc. | Glp-1 receptoriaus agonistai ir jų naudojimas |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| WO2019239371A1 (en) | 2018-06-15 | 2019-12-19 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| IL283322B2 (he) | 2018-11-22 | 2025-08-01 | Qilu Regor Therapeutics Inc | אגוניסטים glp-1r ושימושים בהם |
| CN113853371B (zh) * | 2019-04-12 | 2024-05-03 | 上海齐鲁锐格医药研发有限公司 | Glp-1r激动剂及其用途 |
| TWI751585B (zh) * | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| WO2021018023A1 (zh) | 2019-08-01 | 2021-02-04 | 济南泰达领创医药技术有限公司 | 小分子glp-1受体调节剂 |
| MX2022004874A (es) * | 2019-10-25 | 2022-05-13 | Gilead Sciences Inc | Compuestos de modulacion de glp-1r. |
| UY38958A (es) | 2019-11-15 | 2021-05-31 | Ildong Pharmaceutical Co Ltd | Agonista del receptor glp-1 y uso de este |
| ES3010351T3 (en) | 2019-12-02 | 2025-04-02 | Hyundai Pharm Co Ltd | Glp-1 receptor agonist |
| EP4097097B1 (en) | 2020-01-29 | 2025-01-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| CN115697999A (zh) | 2020-02-13 | 2023-02-03 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| US20230203021A1 (en) | 2020-03-18 | 2023-06-29 | Lg Chem, Ltd. | Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| US20230295154A1 (en) | 2020-04-29 | 2023-09-21 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP7359974B2 (ja) | 2020-06-04 | 2023-10-11 | ハンチョウ サイウィンド バイオサイエンスィズ カンパニー リミテッド | 五員環ヘテロ芳香族イミダゾール系化合物及びその使用 |
| US20230234968A1 (en) | 2020-06-10 | 2023-07-27 | Medshine Discovery Inc. | Methyl-substituted benzobisoxazole compound and use thereof |
| CN113801136B (zh) | 2020-06-16 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 咪唑并杂芳基类衍生物、其制备方法及其在医药上的应用 |
| CN115916772B (zh) | 2020-06-19 | 2025-01-14 | 江苏恒瑞医药股份有限公司 | 6-氧代-3,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
| CN113831337B (zh) | 2020-06-24 | 2023-03-24 | 广州市恒诺康医药科技有限公司 | Glp-1受体激动剂及其药物组合物和用途 |
| TW202214622A (zh) | 2020-08-06 | 2022-04-16 | 大陸商上海齊魯銳格醫藥研發有限公司 | Ｇｌｐ－１ｒ促效劑及其用途 |
| WO2022028572A1 (en) | 2020-08-06 | 2022-02-10 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| BR112023003168A2 (pt) | 2020-08-21 | 2023-05-09 | Terns Pharmaceuticals Inc | Compostos como agonistas do glp-1r |
| EP4204415A4 (en) | 2020-08-28 | 2025-03-26 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| CN119930604A (zh) | 2020-09-01 | 2025-05-06 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
| WO2022068772A1 (zh) | 2020-09-29 | 2022-04-07 | 深圳信立泰药业股份有限公司 | 一种苯并咪唑类衍生物及其制备方法和医药用途 |
| CN116348464A (zh) | 2020-10-12 | 2023-06-27 | 杭州中美华东制药有限公司 | 苯并咪唑酮类glp-1受体激动剂及其用途 |
| EP4229049A4 (en) | 2020-10-13 | 2024-12-18 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2023546055A (ja) | 2020-10-13 | 2023-11-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| CN113480534B (zh) | 2021-07-23 | 2022-05-13 | 广州必贝特医药股份有限公司 | 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用 |
-
2022
- 2022-05-17 TW TW111118381A patent/TWI843104B/zh active
- 2022-05-19 BR BR112023022851A patent/BR112023022851A2/pt unknown
- 2022-05-19 JP JP2023571304A patent/JP7703691B2/ja active Active
- 2022-05-19 MX MX2023013717A patent/MX2023013717A/es unknown
- 2022-05-19 AU AU2022275931A patent/AU2022275931B2/en active Active
- 2022-05-19 KR KR1020237039778A patent/KR20230173166A/ko active Pending
- 2022-05-19 EP EP22729392.5A patent/EP4341255A1/en active Pending
- 2022-05-19 WO PCT/US2022/029958 patent/WO2022246019A1/en not_active Ceased
- 2022-05-19 CA CA3218345A patent/CA3218345A1/en active Pending
- 2022-05-19 IL IL308397A patent/IL308397A/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4341255A1 (en) | 2024-03-27 |
| KR20230173166A (ko) | 2023-12-26 |
| AU2022275931A1 (en) | 2023-11-02 |
| BR112023022851A2 (pt) | 2024-01-23 |
| JP7703691B2 (ja) | 2025-07-07 |
| WO2022246019A1 (en) | 2022-11-24 |
| AU2022275931B2 (en) | 2024-08-15 |
| TW202310838A (zh) | 2023-03-16 |
| TWI843104B (zh) | 2024-05-21 |
| MX2023013717A (es) | 2024-01-16 |
| CA3218345A1 (en) | 2022-11-24 |
| JP2024521073A (ja) | 2024-05-28 |
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