IL303892A - In vitro assembly of RNA-encapsulating enalavirus capsids - Google Patents
In vitro assembly of RNA-encapsulating enalavirus capsidsInfo
- Publication number
- IL303892A IL303892A IL303892A IL30389223A IL303892A IL 303892 A IL303892 A IL 303892A IL 303892 A IL303892 A IL 303892A IL 30389223 A IL30389223 A IL 30389223A IL 303892 A IL303892 A IL 303892A
- Authority
- IL
- Israel
- Prior art keywords
- orf1
- genetic element
- anellovirus
- anellovector
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00041—Use of virus, viral particle or viral elements as a vector
- C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10023—Virus like particles [VLP]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063130360P | 2020-12-23 | 2020-12-23 | |
| US202163147064P | 2021-02-08 | 2021-02-08 | |
| PCT/US2021/064887 WO2022140560A1 (en) | 2020-12-23 | 2021-12-22 | In vitro assembly of anellovirus capsids enclosing rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL303892A true IL303892A (en) | 2023-08-01 |
Family
ID=82160089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL303892A IL303892A (en) | 2020-12-23 | 2021-12-22 | In vitro assembly of RNA-encapsulating enalavirus capsids |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20220372519A1 (enExample) |
| EP (1) | EP4267157A4 (enExample) |
| JP (1) | JP2024501287A (enExample) |
| KR (1) | KR20230124682A (enExample) |
| AU (1) | AU2021409952A1 (enExample) |
| BR (1) | BR112023012460A2 (enExample) |
| CA (1) | CA3206361A1 (enExample) |
| IL (1) | IL303892A (enExample) |
| MX (1) | MX2023007643A (enExample) |
| TW (1) | TW202235622A (enExample) |
| WO (1) | WO2022140560A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3121528A1 (en) | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes and methods of use |
| TW202334423A (zh) | 2021-12-15 | 2023-09-01 | 美商旗艦先鋒創新公司 | 表面經修飾之病毒顆粒及模組化之病毒顆粒 |
| EP4735627A1 (en) * | 2023-06-29 | 2026-05-06 | Life Technologies Corporation | Molecules resistant to nuclease digestion |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2264482A1 (en) | 1996-09-06 | 1998-03-12 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| RU2553223C2 (ru) * | 2009-08-21 | 2015-06-10 | Виргиния Тек Интеллекчуал Пропертиз, Инк. | ВАКЦИНЫ НА ОСНОВЕ СВИНОГО ВИРУСА Torque teNO И СПОСОБЫ ДИАГНОСТИКИ ИНФЕКЦИЙ, ВЫЗВАННЫХ ЭТИМ ВИРУСОМ |
| EP2653562A1 (en) * | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| EP4397759A3 (en) | 2012-10-23 | 2024-10-09 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| PT2931898E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais |
| MX380562B (es) | 2012-12-12 | 2025-03-12 | Broad Inst Inc | Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias. |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| KR102955556B1 (ko) | 2012-12-12 | 2026-04-22 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| CA3066750A1 (en) * | 2017-06-13 | 2018-12-20 | Flagship Pioneering Innovations V, Inc. | Compositions comprising curons and uses thereof |
| MX2020006150A (es) | 2017-12-15 | 2020-11-11 | Flagship Pioneering Innovations Vi Llc | Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas. |
| US11166996B2 (en) * | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
| JP2022513459A (ja) * | 2018-12-12 | 2022-02-08 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | タンパク質代替治療モダリティを送達するためのアネロソーム |
| CA3121528A1 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes and methods of use |
| KR20230036109A (ko) * | 2020-06-12 | 2023-03-14 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 바큘로바이러스 발현 시스템 |
| KR20230041686A (ko) * | 2020-06-17 | 2023-03-24 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 아넬로바이러스를 확인 및 특징화하는 방법 및 이의 용도 |
-
2021
- 2021-12-22 CA CA3206361A patent/CA3206361A1/en active Pending
- 2021-12-22 EP EP21912150.6A patent/EP4267157A4/en active Pending
- 2021-12-22 MX MX2023007643A patent/MX2023007643A/es unknown
- 2021-12-22 IL IL303892A patent/IL303892A/en unknown
- 2021-12-22 KR KR1020237025029A patent/KR20230124682A/ko active Pending
- 2021-12-22 AU AU2021409952A patent/AU2021409952A1/en active Pending
- 2021-12-22 JP JP2023538735A patent/JP2024501287A/ja active Pending
- 2021-12-22 BR BR112023012460A patent/BR112023012460A2/pt unknown
- 2021-12-22 WO PCT/US2021/064887 patent/WO2022140560A1/en not_active Ceased
- 2021-12-22 TW TW110148173A patent/TW202235622A/zh unknown
-
2022
- 2022-06-22 US US17/846,503 patent/US20220372519A1/en not_active Abandoned
-
2025
- 2025-02-18 US US19/056,060 patent/US20250257368A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220372519A1 (en) | 2022-11-24 |
| AU2021409952A1 (en) | 2023-07-06 |
| CA3206361A1 (en) | 2022-06-30 |
| BR112023012460A2 (pt) | 2023-11-07 |
| EP4267157A1 (en) | 2023-11-01 |
| MX2023007643A (es) | 2023-09-04 |
| WO2022140560A1 (en) | 2022-06-30 |
| EP4267157A4 (en) | 2025-05-07 |
| JP2024501287A (ja) | 2024-01-11 |
| US20250257368A1 (en) | 2025-08-14 |
| TW202235622A (zh) | 2022-09-16 |
| KR20230124682A (ko) | 2023-08-25 |
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