IL302649A - A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections - Google Patents
A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infectionsInfo
- Publication number
- IL302649A IL302649A IL302649A IL30264923A IL302649A IL 302649 A IL302649 A IL 302649A IL 302649 A IL302649 A IL 302649A IL 30264923 A IL30264923 A IL 30264923A IL 302649 A IL302649 A IL 302649A
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Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20206287.3A EP3995130A1 (en) | 2020-11-06 | 2020-11-06 | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
| EP21159620 | 2021-02-26 | ||
| PCT/EP2021/080936 WO2022096708A1 (en) | 2020-11-06 | 2021-11-08 | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
Publications (1)
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| IL302649A true IL302649A (en) | 2023-07-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| IL302649A IL302649A (en) | 2020-11-06 | 2021-11-08 | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
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| Country | Link |
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| US (1) | US20230414730A1 (https=) |
| EP (1) | EP4240323A1 (https=) |
| JP (1) | JP2023547728A (https=) |
| AU (1) | AU2021375735A1 (https=) |
| CA (1) | CA3200691A1 (https=) |
| IL (1) | IL302649A (https=) |
| WO (1) | WO2022096708A1 (https=) |
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| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| US12569517B2 (en) | 2019-02-07 | 2026-03-10 | Direct Biologics, Llc | Method for treating osteoarthritis with mesenchymal stem cell exosomes |
| US12213995B2 (en) | 2019-07-18 | 2025-02-04 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| CN115381857B (zh) * | 2022-10-28 | 2023-02-03 | 上海市东方医院（同济大学附属东方医院） | 间充质干细胞在制备治疗hpv持续感染的药物中的应用 |
| EP4680254A1 (en) * | 2023-03-17 | 2026-01-21 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cell-derived exosome drug delivery for cancer and other disorders |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| WO2025227013A1 (en) * | 2024-04-26 | 2025-10-30 | Musc Foundation For Research Development | Extracellular vesicles from alpha-1 antitrypsin overexpressing cells |
Family Cites Families (8)
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| US5376633A (en) * | 1992-09-30 | 1994-12-27 | Lezdey; John | Method for deactivating viruses in blood component containers |
| EP1366175B1 (en) * | 2000-12-18 | 2008-01-23 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| EP2148693A4 (en) * | 2007-04-20 | 2010-06-02 | Univ Colorado | ALPHA-I-ANTITRYPINE WITHOUT SIGNIFICANT SERINE PROTEASE INHIBITOR ACTIVITY |
| RU2539099C2 (ru) | 2009-04-13 | 2015-01-10 | Апцет Гмбх Унд Ко.Кг | Сконструированные мезенхимальные стволовые клетки и способ их применения для лечения опухолей |
| US9901600B2 (en) * | 2011-03-11 | 2018-02-27 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| PL3242933T3 (pl) * | 2015-01-08 | 2019-08-30 | Apceth Gmbh & Co. Kg | Zmodyfikowane genetycznie mezenchymalne komórki macierzyste wykazujące ekspresję alfa-1 antytrypsyny (aat) |
| WO2016146819A1 (en) * | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
| CA3117961A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
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- 2021-11-08 EP EP21815373.2A patent/EP4240323A1/en active Pending
- 2021-11-08 CA CA3200691A patent/CA3200691A1/en active Pending
- 2021-11-08 WO PCT/EP2021/080936 patent/WO2022096708A1/en not_active Ceased
- 2021-11-08 US US18/035,707 patent/US20230414730A1/en active Pending
- 2021-11-08 IL IL302649A patent/IL302649A/en unknown
- 2021-11-08 JP JP2023527970A patent/JP2023547728A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023547728A (ja) | 2023-11-13 |
| AU2021375735A9 (en) | 2024-09-05 |
| CA3200691A1 (en) | 2022-05-12 |
| US20230414730A1 (en) | 2023-12-28 |
| EP4240323A1 (en) | 2023-09-13 |
| AU2021375735A1 (en) | 2023-06-08 |
| WO2022096708A1 (en) | 2022-05-12 |
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