IL302519A - Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers - Google Patents
Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkersInfo
- Publication number
- IL302519A IL302519A IL302519A IL30251923A IL302519A IL 302519 A IL302519 A IL 302519A IL 302519 A IL302519 A IL 302519A IL 30251923 A IL30251923 A IL 30251923A IL 302519 A IL302519 A IL 302519A
- Authority
- IL
- Israel
- Prior art keywords
- ifny
- patients
- seq
- hlh
- mas
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/521—Chemokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158153P | 2015-05-07 | 2015-05-07 | |
| US201562221393P | 2015-09-21 | 2015-09-21 | |
| US201562246949P | 2015-10-27 | 2015-10-27 | |
| PCT/EP2016/060360 WO2016177913A1 (en) | 2015-05-07 | 2016-05-09 | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL302519A true IL302519A (en) | 2023-07-01 |
Family
ID=56008603
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL302519A IL302519A (en) | 2015-05-07 | 2016-05-09 | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
| IL282923A IL282923B2 (en) | 2015-05-07 | 2016-05-09 | Methods and preparations for diagnosis and treatment of disorders in patients with high levels of chemokine C.-X.-C. Ligand 9 and other biomarkers |
| IL255440A IL255440B (en) | 2015-05-07 | 2017-11-05 | Methods and preparations for the diagnosis and treatment of disorders in patients with high levels of chemokine C.-X.-C. Ligand 9 and other biomarkers |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL282923A IL282923B2 (en) | 2015-05-07 | 2016-05-09 | Methods and preparations for diagnosis and treatment of disorders in patients with high levels of chemokine C.-X.-C. Ligand 9 and other biomarkers |
| IL255440A IL255440B (en) | 2015-05-07 | 2017-11-05 | Methods and preparations for the diagnosis and treatment of disorders in patients with high levels of chemokine C.-X.-C. Ligand 9 and other biomarkers |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11034760B2 (enExample) |
| EP (1) | EP3292147A1 (enExample) |
| JP (4) | JP2018515493A (enExample) |
| KR (1) | KR20180004254A (enExample) |
| CN (1) | CN107849127A (enExample) |
| AU (1) | AU2016257023B2 (enExample) |
| BR (1) | BR112017023867A2 (enExample) |
| CA (1) | CA2985001A1 (enExample) |
| EA (1) | EA037532B1 (enExample) |
| IL (3) | IL302519A (enExample) |
| MX (3) | MX2017014294A (enExample) |
| SG (1) | SG10202108996PA (enExample) |
| WO (1) | WO2016177913A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| WO2016177913A1 (en) * | 2015-05-07 | 2016-11-10 | Novimmune Sa | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
| EP3307318A4 (en) | 2015-06-09 | 2019-01-16 | Children's Hospital Medical Center | DOSAGE ALGORITHM FOR COMPLEMENT INHIBITOR |
| AU2017352033A1 (en) * | 2016-10-24 | 2019-06-06 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| CN107942079B (zh) * | 2017-11-27 | 2019-05-03 | 首都医科大学附属北京友谊医院 | 细胞因子在噬血细胞综合征的诊断和分型中的应用 |
| EP3717004A4 (en) * | 2017-12-01 | 2021-12-01 | Children's Hospital Medical Center | COMPOSITIONS FOR BLOCKING INTERERONS AND THEIR METHODS OF USE |
| WO2019173676A1 (en) * | 2018-03-09 | 2019-09-12 | Children's Hospital Medical Center | Compositions and methods for the treatment of macrophage activation syndrome |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| WO2021185832A1 (en) | 2020-03-16 | 2021-09-23 | Swedish Orphan Biovitrum Ag | New therapeutic treatment |
| JP7396213B2 (ja) * | 2020-06-22 | 2023-12-12 | Tdk株式会社 | データ解析システム、データ解析方法及びデータ解析プログラム |
| CN115812671B (zh) * | 2022-11-17 | 2024-07-19 | 青岛大学 | 帕金森病动物模型的建立方法及其应用 |
| WO2024254401A1 (en) | 2023-06-09 | 2024-12-12 | Children's Hospital Medical Center | Treatment of stem cell graft failure |
| CN118266439A (zh) * | 2024-04-26 | 2024-07-02 | 倍科为(天津)生物技术有限公司 | 一种斑马鱼继发性噬血细胞综合征模型的构建方法及应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096705A (en) | 1981-10-19 | 1992-03-17 | Genentech, Inc. | Human immune interferon |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4599306A (en) | 1983-04-15 | 1986-07-08 | Amgen | Monoclonal antibodies which specifically bind to human immune interferon |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| JP3887011B2 (ja) | 1992-12-29 | 2007-02-28 | ジェネンテク，インコーポレイテッド | ＩＦＮ−γインヒビターによる炎症性腸疾患の処置 |
| US20030059428A1 (en) | 1993-02-26 | 2003-03-27 | Boris Skurkovich | Treatment of autoimmune diseases |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| MXPA01005515A (es) | 1998-12-01 | 2003-07-14 | Protein Design Labs Inc | Anticuerpos humanizados para gamma-interferon. |
| US6534059B2 (en) | 2001-06-05 | 2003-03-18 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
| US6861056B2 (en) | 2001-06-05 | 2005-03-01 | Advanced Biotherapy, Inc. | Compositions and methods for treating hyperimmune response in the eye |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| IL161677A0 (en) | 2001-11-08 | 2004-09-27 | Protein Design Labs | Stable liquid pharmaceutical formulation of igg antibodies |
| CA2486147A1 (en) | 2002-05-17 | 2003-11-27 | Protein Design Labs, Inc. | Treatment of crohn's disease or psoriasis using anti-inteferon gamma antibodies |
| US20040052791A1 (en) | 2002-05-22 | 2004-03-18 | Rolf Ehrhardt | Treatment of Crohn's disease or psoriasis using anti-interferon gamma antibodies |
| US7335743B2 (en) | 2002-10-16 | 2008-02-26 | Amgen Inc. | Human anti-IFN-γ neutralizing antibodies as selective IFN-γ pathway inhibitors |
| GB0314461D0 (en) | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| DK1848744T3 (da) * | 2005-01-27 | 2012-03-19 | Novimmune Sa | Humane anti-interferon-gamma-antistoffer og fremgangsmåder til anvendelse heraf |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| GB0607943D0 (en) | 2006-04-21 | 2006-05-31 | Novartis Ag | Biomarkers for chronic transplant dysfunction |
| WO2008121615A2 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Inc. | Antibody formulation |
| NZ585516A (en) | 2007-12-21 | 2012-07-27 | Hoffmann La Roche | Anti-cd20 antibody formulation |
| WO2010042705A1 (en) | 2008-10-09 | 2010-04-15 | Medimmune, Llc | Antibody formulation |
| JP2012519712A (ja) | 2009-03-06 | 2012-08-30 | メディミューン，エルエルシー | ヒト化抗ｃｄ１９抗体製剤 |
| EP2519262A2 (en) * | 2009-12-29 | 2012-11-07 | F. Hoffmann-La Roche AG | Antibody formulation |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| KR102031020B1 (ko) * | 2011-03-31 | 2019-10-14 | 머크 샤프 앤드 돔 코포레이션 | 인간 프로그램화된 사멸 수용체 pd-1에 대한 항체의 안정한 제제 및 관련된 치료 |
| WO2013078378A1 (en) | 2011-11-23 | 2013-05-30 | Amgen Inc. | Methods of treatment using an antibody against interferon gamma |
| KR20170018810A (ko) | 2014-06-10 | 2017-02-20 | 메이지 세이카 파루마 가부시키가이샤 | 안정한 아달리무맙 수성 제제 |
| US20170360929A1 (en) * | 2014-12-23 | 2017-12-21 | Pfizer Inc. | Stable aqueous antibody formulation for anti tnf alpha antibodies |
| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| WO2016177913A1 (en) | 2015-05-07 | 2016-11-10 | Novimmune Sa | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
| AU2017352033A1 (en) | 2016-10-24 | 2019-06-06 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
-
2016
- 2016-05-09 WO PCT/EP2016/060360 patent/WO2016177913A1/en not_active Ceased
- 2016-05-09 IL IL302519A patent/IL302519A/en unknown
- 2016-05-09 JP JP2017557901A patent/JP2018515493A/ja active Pending
- 2016-05-09 BR BR112017023867A patent/BR112017023867A2/pt active Search and Examination
- 2016-05-09 IL IL282923A patent/IL282923B2/en unknown
- 2016-05-09 EP EP16723063.0A patent/EP3292147A1/en active Pending
- 2016-05-09 EA EA201792447A patent/EA037532B1/ru unknown
- 2016-05-09 MX MX2017014294A patent/MX2017014294A/es unknown
- 2016-05-09 CA CA2985001A patent/CA2985001A1/en active Pending
- 2016-05-09 US US15/149,633 patent/US11034760B2/en active Active
- 2016-05-09 SG SG10202108996PA patent/SG10202108996PA/en unknown
- 2016-05-09 AU AU2016257023A patent/AU2016257023B2/en active Active
- 2016-05-09 KR KR1020177035421A patent/KR20180004254A/ko not_active Ceased
- 2016-05-09 CN CN201680040022.8A patent/CN107849127A/zh active Pending
-
2017
- 2017-11-05 IL IL255440A patent/IL255440B/en unknown
- 2017-11-07 MX MX2022001008A patent/MX2022001008A/es unknown
- 2017-11-07 MX MX2024001909A patent/MX2024001909A/es unknown
-
2020
- 2020-12-14 US US17/121,513 patent/US12275785B2/en active Active
-
2021
- 2021-03-09 JP JP2021036849A patent/JP2021100943A/ja active Pending
-
2023
- 2023-05-11 JP JP2023078474A patent/JP7685008B2/ja active Active
-
2025
- 2025-05-16 JP JP2025082282A patent/JP2025118898A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2985001A1 (en) | 2016-11-10 |
| JP2025118898A (ja) | 2025-08-13 |
| IL282923B1 (en) | 2023-06-01 |
| MX2022001008A (es) | 2022-02-22 |
| AU2016257023A1 (en) | 2017-11-30 |
| SG10202108996PA (en) | 2021-09-29 |
| JP2021100943A (ja) | 2021-07-08 |
| US11034760B2 (en) | 2021-06-15 |
| EP3292147A1 (en) | 2018-03-14 |
| IL255440B (en) | 2021-08-31 |
| JP2018515493A (ja) | 2018-06-14 |
| US20160326244A1 (en) | 2016-11-10 |
| IL282923A (en) | 2021-06-30 |
| US12275785B2 (en) | 2025-04-15 |
| MX2024001909A (es) | 2024-02-28 |
| JP2023090964A (ja) | 2023-06-29 |
| MX2017014294A (es) | 2018-08-09 |
| JP7685008B2 (ja) | 2025-05-28 |
| BR112017023867A2 (pt) | 2018-07-24 |
| IL282923B2 (en) | 2023-10-01 |
| KR20180004254A (ko) | 2018-01-10 |
| IL255440A0 (en) | 2017-12-31 |
| US20210101972A1 (en) | 2021-04-08 |
| EA201792447A1 (ru) | 2018-05-31 |
| AU2016257023B2 (en) | 2022-06-30 |
| WO2016177913A1 (en) | 2016-11-10 |
| EA037532B1 (ru) | 2021-04-08 |
| CN107849127A (zh) | 2018-03-27 |
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