IL301857A - Engineered phosphopentomutase variant enzymes - Google Patents

Engineered phosphopentomutase variant enzymes

Info

Publication number
IL301857A
IL301857A IL301857A IL30185723A IL301857A IL 301857 A IL301857 A IL 301857A IL 301857 A IL301857 A IL 301857A IL 30185723 A IL30185723 A IL 30185723A IL 301857 A IL301857 A IL 301857A
Authority
IL
Israel
Prior art keywords
thc
seq
sequence
engineered phosphopentomutase
phosphopentomutase
Prior art date
Application number
IL301857A
Other languages
English (en)
Hebrew (he)
Inventor
Jonathan Vroom
Santhosh Sivaramakrishnan
Jessica Anna Hurtak
Original Assignee
Codexis Inc
Jonathan Vroom
Santhosh Sivaramakrishnan
Jessica Anna Hurtak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc, Jonathan Vroom, Santhosh Sivaramakrishnan, Jessica Anna Hurtak filed Critical Codexis Inc
Publication of IL301857A publication Critical patent/IL301857A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y504/00Intramolecular transferases (5.4)
    • C12Y504/02Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02007Phosphopentomutase (5.4.2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1058Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL301857A 2020-10-07 2021-10-05 Engineered phosphopentomutase variant enzymes IL301857A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063088556P 2020-10-07 2020-10-07
PCT/US2021/053626 WO2022076454A1 (en) 2020-10-07 2021-10-05 Engineered phosphopentomutase variant enzymes

Publications (1)

Publication Number Publication Date
IL301857A true IL301857A (en) 2023-06-01

Family

ID=81125465

Family Applications (1)

Application Number Title Priority Date Filing Date
IL301857A IL301857A (en) 2020-10-07 2021-10-05 Engineered phosphopentomutase variant enzymes

Country Status (8)

Country Link
US (1) US20230374486A1 (https=)
EP (1) EP4225909A4 (https=)
JP (1) JP2023544783A (https=)
CN (1) CN116710558A (https=)
AU (1) AU2021358938A1 (https=)
CA (1) CA3196715A1 (https=)
IL (1) IL301857A (https=)
WO (1) WO2022076454A1 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1858920T1 (sl) * 2005-02-18 2016-07-29 Glaxosmithkline Biologicals S.A. Proteini in nukleinske kisline iz escherichia coli, povezane z meningitisom/sepso
EP3821026A4 (en) * 2018-07-09 2022-06-01 Codexis, Inc. MANIPULATED ENZYME VARIANTS OF PHOSPHOPENTOMUTASE

Also Published As

Publication number Publication date
JP2023544783A (ja) 2023-10-25
US20230374486A1 (en) 2023-11-23
EP4225909A4 (en) 2025-02-12
CN116710558A (zh) 2023-09-05
AU2021358938A1 (en) 2023-04-27
WO2022076454A1 (en) 2022-04-14
CA3196715A1 (en) 2022-04-14
EP4225909A1 (en) 2023-08-16

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