IL301476A - Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis - Google Patents
Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosisInfo
- Publication number
- IL301476A IL301476A IL301476A IL30147623A IL301476A IL 301476 A IL301476 A IL 301476A IL 301476 A IL301476 A IL 301476A IL 30147623 A IL30147623 A IL 30147623A IL 301476 A IL301476 A IL 301476A
- Authority
- IL
- Israel
- Prior art keywords
- subject
- gdf11
- composition
- preventing
- polypeptide
- Prior art date
Links
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
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| US201662275645P | 2016-01-06 | 2016-01-06 | |
| PCT/US2017/012505 WO2017120450A1 (en) | 2016-01-06 | 2017-01-06 | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
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| IL285371A IL285371B (en) | 2016-01-06 | 2017-01-06 | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
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| IL260468A IL260468B (en) | 2016-01-06 | 2018-07-08 | Treatment with gdf11 prevents weight gain, improves glucose loading and reduces hepatosteatosis |
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| IL293766A IL293766B2 (en) | 2016-01-06 | 2017-01-06 | Treatment with gdf11 prevents weight gain, improves glucose loading and reduces hepatosteatosis |
| IL260468A IL260468B (en) | 2016-01-06 | 2018-07-08 | Treatment with gdf11 prevents weight gain, improves glucose loading and reduces hepatosteatosis |
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| JP2016518357A (ja) | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
| CA3010799A1 (en) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| CN108619492A (zh) * | 2018-05-31 | 2018-10-09 | 暨南大学 | Gdf11在制备用于治疗肥胖的产品中的应用及治疗肥胖的产品 |
| US10804162B2 (en) | 2018-09-27 | 2020-10-13 | Taiwan Semiconductor Manufacturing Co., Ltd. | Dual channel gate all around transistor device and fabrication methods thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| PT698094E (pt) | 1993-05-12 | 2004-05-31 | Inst Genetics Llc | Composicoes de bmp-11 |
| CA2194660C (en) | 1994-07-08 | 2009-09-29 | Se-Jin Lee | Growth differentiation factor-11 |
| US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| EP0985149A1 (en) | 1997-05-30 | 2000-03-15 | Creative Biomolecules, Inc. | Methods for evaluating tissue morphogenesis and activity |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US7795202B2 (en) | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
| US6953662B2 (en) | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
| AU1276399A (en) | 1997-11-07 | 1999-05-31 | Genetics Institute Inc. | Neuronal uses of bmp-11 |
| US20030170213A1 (en) | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| DK1097233T3 (da) | 1998-07-15 | 2009-03-23 | Metamorphix Inc | Promotor for vækstdifferentieringsfaktor og anvendelser deraf |
| US7572440B2 (en) | 1999-07-30 | 2009-08-11 | Stryker Corporation | Method for repairing a defect in an intervertebral disc |
| US20030224501A1 (en) | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| US20030104977A1 (en) | 2000-03-31 | 2003-06-05 | Ugo Ripamonti | Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors |
| EP1790726B1 (en) | 2001-02-08 | 2013-07-03 | Wyeth LLC | Modified and stabilized GDF propeptides and uses thereof |
| TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US20060078532A1 (en) | 2004-10-12 | 2006-04-13 | Omoigui Osemwota S | Method of prevention and treatment of Atherosclerosis, Peripheral vascular disease, Coronary artery disease, aging and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease |
| WO2004073633A2 (en) * | 2003-02-14 | 2004-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for modulating the development of stem cells |
| NZ529860A (en) | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| US7388027B2 (en) | 2004-03-04 | 2008-06-17 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| AU2005227896B2 (en) | 2004-03-23 | 2008-11-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| ES2551852T3 (es) | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| US20060216279A1 (en) | 2005-03-22 | 2006-09-28 | Glass David J | Myostatin inhibiting fusion polypeptides and therapeutic methods thereof |
| EA201100642A1 (ru) | 2005-04-25 | 2011-12-30 | Пфайзер Инк. | Антитела к миостатину |
| US20090215671A1 (en) | 2005-05-27 | 2009-08-27 | The Regents Of The University Of California | Compositions And Methods For Treatment of Neural Disorders Using Transforming Growth Factor-Beta Superfamily Proteins And Their Antagonists |
| PT2407486T (pt) | 2005-08-19 | 2018-02-21 | Univ Pennsylvania | Anticorpos antagonistas contra gdf-8 e utilizações no tratamento de ela e outros distúrbios associados a gdf-8 |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| WO2007109686A2 (en) | 2006-03-20 | 2007-09-27 | University Of Pittsburgh | Immunomodulation of inflammatory conditions utilizing follistatin-like protein-1 and agents that bind thereto |
| US20080044387A1 (en) | 2006-03-24 | 2008-02-21 | The Regents Of The University Of California | Artificial niches for enhancement of regenerative capacity of stem cells in aged and pathological environments |
| WO2007142818A2 (en) | 2006-05-17 | 2007-12-13 | Stryker Corporation | Use of a soluble morphogenic protein complex for treating cartilage defects |
| WO2008021196A2 (en) | 2006-08-09 | 2008-02-21 | The Mclean Hospital Corporation | Methods and compositions for the treatment of medical disorders |
| TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| WO2009021234A1 (en) * | 2007-08-09 | 2009-02-12 | Cincinnati Children's Hospital Medical Center | Methods of treatment and prevention of diet- induced obesity and sequelae thereof |
| CA2718854A1 (en) | 2008-03-20 | 2009-09-24 | Transmolecular, Inc. | Inhibition of angiogenesis |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| US8969081B2 (en) | 2008-12-10 | 2015-03-03 | The Trustees Of Columbia University In The City Of New York | Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid |
| US8952130B2 (en) | 2009-02-24 | 2015-02-10 | The Salk Institute For Biological Studies | Designer ligands of TGF-β superfamily |
| WO2011130347A2 (en) | 2010-04-13 | 2011-10-20 | The Johns Hopkins University | Methods for enhancing axonal regeneration |
| WO2012135623A1 (en) | 2011-03-31 | 2012-10-04 | Theravasc Inc. | Use of nitrites for the treatment of cerebral amyloid angiopathy, age associated dementia, and cognitive decline |
| US8765385B2 (en) * | 2011-10-27 | 2014-07-01 | Ravindra Kumar | Method of detection of neutralizing anti-actriib antibodies |
| JP6124986B2 (ja) * | 2012-03-19 | 2017-05-10 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 拡張期心不全を処置するための増殖分化因子(gdf) |
| JP2016518357A (ja) | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
| KR102423106B1 (ko) | 2013-06-11 | 2022-07-21 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| EP3881859B1 (en) | 2013-06-11 | 2024-03-06 | President and Fellows of Harvard College | Compositions for increasing neurogenesis and angiogenesis |
| US9884090B2 (en) | 2013-09-03 | 2018-02-06 | Mayo Foundation For Medical Education And Research | Using nucleic acids encoding NAP-2 and TGF-alpha polypeptides to improve cardiac function |
| WO2015070076A2 (en) | 2013-11-08 | 2015-05-14 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating neuromuscular junctions |
| WO2015073396A1 (en) | 2013-11-12 | 2015-05-21 | The Brigham And Women's Hospital, Inc. | Growth differentiation factor (gdf) for treatment of diastolic heart failure |
| EP3139957A4 (en) | 2014-05-06 | 2018-04-25 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
| WO2016049662A1 (en) | 2014-09-23 | 2016-03-31 | President And Fellows Of Harvard College | Methods and compositions for treating age-related disorders |
| CA3010799A1 (en) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| WO2018067754A1 (en) | 2016-10-04 | 2018-04-12 | Fairbanks Pharmaceuticals, Inc. | Anti-fstl3 antibodies and uses thereof |
| WO2019144053A1 (en) | 2018-01-19 | 2019-07-25 | President And Fellows Of Harward College | Gdf11 variants and uses thereof |
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| ES2893813T3 (es) | 2022-02-10 |
| IL293766A (en) | 2022-08-01 |
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| CN116059320A (zh) | 2023-05-05 |
| JP6948331B2 (ja) | 2021-10-13 |
| IL260468B (en) | 2021-08-31 |
| HK1257377A1 (en) | 2019-10-18 |
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| US20190015479A1 (en) | 2019-01-17 |
| JP2023014339A (ja) | 2023-01-26 |
| EP3399998A1 (en) | 2018-11-14 |
| JP7288012B2 (ja) | 2023-06-06 |
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| EP3399998A4 (en) | 2019-11-06 |
| US11890321B2 (en) | 2024-02-06 |
| IL285371B (en) | 2022-07-01 |
| US20210308221A1 (en) | 2021-10-07 |
| EP3949979A1 (en) | 2022-02-09 |
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