IL299547A - צורות גבישיות של 2-[4-[(2, 3, 4, -טרימטוקסיפניל)מתיל]פיפראזין-1-איל]מתיל פירידין-3-קרבוקסילאט ושיטות לסינתיזה - Google Patents

צורות גבישיות של 2-[4-[(2, 3, 4, -טרימטוקסיפניל)מתיל]פיפראזין-1-איל]מתיל פירידין-3-קרבוקסילאט ושיטות לסינתיזה

Info

Publication number
IL299547A
IL299547A IL299547A IL29954722A IL299547A IL 299547 A IL299547 A IL 299547A IL 299547 A IL299547 A IL 299547A IL 29954722 A IL29954722 A IL 29954722A IL 299547 A IL299547 A IL 299547A
Authority
IL
Israel
Prior art keywords
compound
formula
composition
free base
crystal
Prior art date
Application number
IL299547A
Other languages
English (en)
Original Assignee
Imbria Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imbria Pharmaceuticals Inc filed Critical Imbria Pharmaceuticals Inc
Publication of IL299547A publication Critical patent/IL299547A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL299547A 2020-06-30 2021-06-28 צורות גבישיות של 2-[4-[(2, 3, 4, -טרימטוקסיפניל)מתיל]פיפראזין-1-איל]מתיל פירידין-3-קרבוקסילאט ושיטות לסינתיזה IL299547A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063046120P 2020-06-30 2020-06-30
US202063046123P 2020-06-30 2020-06-30
PCT/US2021/039305 WO2022005928A1 (en) 2020-06-30 2021-06-28 Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin -1-yl]ethyl pyridine-3-carboxylate and methods of synthesis

Publications (1)

Publication Number Publication Date
IL299547A true IL299547A (he) 2023-02-01

Family

ID=79314883

Family Applications (1)

Application Number Title Priority Date Filing Date
IL299547A IL299547A (he) 2020-06-30 2021-06-28 צורות גבישיות של 2-[4-[(2, 3, 4, -טרימטוקסיפניל)מתיל]פיפראזין-1-איל]מתיל פירידין-3-קרבוקסילאט ושיטות לסינתיזה

Country Status (8)

Country Link
EP (1) EP4171233A4 (he)
JP (2) JP7792920B2 (he)
KR (1) KR20230031320A (he)
CN (1) CN116056711B (he)
AU (1) AU2021299266A1 (he)
CA (1) CA3188286A1 (he)
IL (1) IL299547A (he)
WO (1) WO2022005928A1 (he)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4531845A4 (en) * 2022-06-03 2026-04-29 Imbria Pharmaceuticals Inc COMPOUNDS AND METHODS FOR INCREASING THE EFFICIENCY OF CARDIAC METABOLISM

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169279B2 (en) * 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
CN102850296B (zh) * 2012-09-29 2015-01-07 瑞阳制药有限公司 曲美他嗪的制备方法
WO2018236745A1 (en) * 2017-06-20 2018-12-27 Carnot, Llc COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CARDIAC METABOLISM
US20220249463A1 (en) * 2019-05-31 2022-08-11 Imbria Pharmaceuticals, Inc. Methods of altering cardiac remodeling using compounds that promote glucose oxidation
EP3976101A4 (en) * 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION

Also Published As

Publication number Publication date
CN116056711A (zh) 2023-05-02
WO2022005928A1 (en) 2022-01-06
CA3188286A1 (en) 2022-01-06
AU2021299266A1 (en) 2023-02-02
EP4171233A4 (en) 2024-08-21
JP2026027462A (ja) 2026-02-18
KR20230031320A (ko) 2023-03-07
JP2023532330A (ja) 2023-07-27
EP4171233A1 (en) 2023-05-03
JP7792920B2 (ja) 2025-12-26
CN116056711B (zh) 2026-03-31

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