IL299491A - Methods and compositions for B2M LOCUS editing in B cells - Google Patents
Methods and compositions for B2M LOCUS editing in B cellsInfo
- Publication number
- IL299491A IL299491A IL299491A IL29949122A IL299491A IL 299491 A IL299491 A IL 299491A IL 299491 A IL299491 A IL 299491A IL 29949122 A IL29949122 A IL 29949122A IL 299491 A IL299491 A IL 299491A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- modified
- gene
- nuclease
- cells
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
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- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C12N2310/00—Structure or type of the nucleic acid
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063047978P | 2020-07-03 | 2020-07-03 | |
| US202063114131P | 2020-11-16 | 2020-11-16 | |
| PCT/US2021/039953 WO2022006309A1 (en) | 2020-07-03 | 2021-06-30 | Methods and compositions for editing the b2m locus in b cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL299491A true IL299491A (en) | 2023-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL299491A IL299491A (en) | 2020-07-03 | 2021-06-30 | Methods and compositions for B2M LOCUS editing in B cells |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4175651A1 (ko) |
| JP (1) | JP2023532917A (ko) |
| KR (1) | KR20230035048A (ko) |
| CN (1) | CN116033910A (ko) |
| AU (1) | AU2021300358A1 (ko) |
| BR (1) | BR112022026534A2 (ko) |
| CA (1) | CA3186620A1 (ko) |
| IL (1) | IL299491A (ko) |
| MX (1) | MX2022015788A (ko) |
| WO (1) | WO2022006309A1 (ko) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024030857A1 (en) * | 2022-08-01 | 2024-02-08 | Idexx Laboratories, Inc. | Human mouse fractional abundance assays |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL297018A (en) * | 2015-12-18 | 2022-12-01 | Sangamo Therapeutics Inc | Directed cleavage of cell mhc receptor |
| EP3645036A1 (en) * | 2017-06-30 | 2020-05-06 | Cellectis | Cellular immunotherapy for repetitive administration |
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2021
- 2021-06-30 WO PCT/US2021/039953 patent/WO2022006309A1/en active Application Filing
- 2021-06-30 AU AU2021300358A patent/AU2021300358A1/en active Pending
- 2021-06-30 EP EP21832140.4A patent/EP4175651A1/en active Pending
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- 2021-06-30 CN CN202180047549.4A patent/CN116033910A/zh active Pending
- 2021-06-30 IL IL299491A patent/IL299491A/en unknown
- 2021-06-30 KR KR1020237001885A patent/KR20230035048A/ko unknown
- 2021-06-30 BR BR112022026534A patent/BR112022026534A2/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230035048A (ko) | 2023-03-10 |
| EP4175651A1 (en) | 2023-05-10 |
| CA3186620A1 (en) | 2022-01-06 |
| MX2022015788A (es) | 2023-02-27 |
| BR112022026534A2 (pt) | 2023-04-18 |
| JP2023532917A (ja) | 2023-08-01 |
| WO2022006309A1 (en) | 2022-01-06 |
| AU2021300358A1 (en) | 2023-02-02 |
| CN116033910A (zh) | 2023-04-28 |
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