IL299482B2 - Mammalian cells are enriched with active mitochondria - Google Patents
Mammalian cells are enriched with active mitochondriaInfo
- Publication number
- IL299482B2 IL299482B2 IL299482A IL29948222A IL299482B2 IL 299482 B2 IL299482 B2 IL 299482B2 IL 299482 A IL299482 A IL 299482A IL 29948222 A IL29948222 A IL 29948222A IL 299482 B2 IL299482 B2 IL 299482B2
- Authority
- IL
- Israel
- Prior art keywords
- bone
- composition
- marrow cells
- mitochondrial
- cells
- Prior art date
Links
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| IL282198B2 (en) | 2011-09-11 | 2025-11-01 | Minovia Therapeutics Ltd | Compositions of functional mitochondria and uses thereof |
| CN106536056B (zh) | 2014-06-13 | 2021-07-16 | 儿童医学中心公司 | 分离线粒体的产品和方法 |
| US11903974B2 (en) | 2015-11-30 | 2024-02-20 | Flagship Pioneering Innovations V, Inc. | Methods and compositions relating to chondrisomes from cultured cells |
| WO2017124037A1 (en) | 2016-01-15 | 2017-07-20 | The Children's Medical Center Corporation | Therapeutic use of mitochondria and combined mitochondrial agents |
| KR101846464B1 (ko) | 2016-11-14 | 2018-04-09 | 주식회사 파이안바이오테크놀로지 | 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물 |
| JP7187036B2 (ja) * | 2016-11-14 | 2022-12-12 | パイアン バイオテクノロジ－ インコーポレイテッド | 外因性ミトコンドリアを細胞内に送達する方法 |
| JP2020502078A (ja) * | 2016-11-30 | 2020-01-23 | パイアン・バイオテクノロジー・インコーポレイテッドＰａｅａｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｃ． | ミトコンドリアを含む医薬組成物 |
| WO2018178970A1 (en) * | 2017-03-26 | 2018-10-04 | Minovia Therapeutics Ltd. | Mitochondrial compositions and methods for treatment of skin and hair |
| WO2019183042A1 (en) * | 2018-03-20 | 2019-09-26 | Unity Biotechnology, Inc. | Autologous mitochondrial extraction and expansion |
| EP3773639A4 (en) * | 2018-03-27 | 2021-08-11 | Minovia Therapeutics Ltd. | LIPID AND CHOLESTEROL METABOLISM RAISING PROCESSES |
| EP3823646A4 (en) * | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of brain diseases |
| EP3823644A4 (en) * | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES |
| JP7586811B2 (ja) * | 2018-07-22 | 2024-11-19 | ミノヴィア セラピューティクス リミテッド | 腎臓疾患のミトコンドリア増強療法 |
| EP3823643A4 (en) * | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF LIVER DISEASES |
| AU2019311859B2 (en) * | 2018-07-22 | 2025-12-18 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| WO2020021535A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| US11951135B2 (en) | 2018-07-22 | 2024-04-09 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| US20210322485A1 (en) * | 2018-07-22 | 2021-10-21 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria |
| US20200054682A1 (en) * | 2018-08-14 | 2020-02-20 | Imel Biotherapeutics, Inc. | Methods and compositions for treating mitochondrial disease or disorders and heteroplasmy |
| CN112912087A (zh) * | 2018-09-14 | 2021-06-04 | 卢卡科学株式会社 | 线粒体向淋巴器官中的移植以及用于该移植的组合物 |
| AU2020207410A1 (en) * | 2019-01-11 | 2021-08-19 | Figene, Llc | Fibroblast regenerative cells |
| JP7745544B2 (ja) * | 2019-10-24 | 2025-09-29 | イメル バイオセラピューティクス，インク． | ミトコンドリアｄｎａ中のマクロヘテロプラスミー及びミクロヘテロプラスミーを検出するための方法 |
| US12091684B2 (en) * | 2020-02-14 | 2024-09-17 | Hackensack Meridian Health, Inc. | Platelet-derived mitochondria treatment and method of generating multipotent cells |
| TWI857807B (zh) * | 2020-03-20 | 2024-10-01 | 台灣粒線體應用技術股份有限公司 | 含有粒線體之組合物及其用於作為皮膚纖維母細胞活性促進劑之用途 |
| BR112022019609A2 (pt) * | 2020-03-31 | 2022-11-29 | Minovia Therapeutics Ltd | Células geneticamente modificadas enriquecidas com mitocôndrias e usos das mesmas |
| AU2021248780A1 (en) * | 2020-03-31 | 2022-11-10 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy |
| WO2021224920A1 (en) * | 2020-05-05 | 2021-11-11 | Pluristem Ltd. | Methods and compositions for enrichment of target cells |
| AU2023356237A1 (en) * | 2022-10-06 | 2025-05-22 | Mitrix Bio Inc. | Formulations and methods for cellular therapies involving chimeric antigen receptors |
| CN116478920B (zh) * | 2023-05-05 | 2025-03-25 | 重庆理工大学 | 一种离体线粒体的体外储存方法 |
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| US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
| WO2013035101A1 (en) * | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
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| AU2002330938A1 (en) | 2001-07-31 | 2003-02-17 | Northeastern University | Mitochondrial genome replenishment |
| US20050153381A1 (en) * | 2002-02-14 | 2005-07-14 | Marusich Michael F. | Immunocapture of mitochondrial protein complexes |
| CA2525560A1 (en) | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| US7407800B1 (en) | 2003-09-19 | 2008-08-05 | Pierce Biotechnology, Inc. | Method for the isolation of intact mitochondria from cells |
| US9603872B2 (en) | 2007-05-02 | 2017-03-28 | The McLeon Hospital Corporation | Methods and compositions for mitochondrial replacement therapy |
| WO2008152640A2 (en) | 2007-06-13 | 2008-12-18 | Pluristem Ltd. | Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells |
| JP5866601B2 (ja) | 2008-06-18 | 2016-02-17 | ザ テキサス エーアンドエム ユニバーシティ システムＴｈｅ Ｔｅｘａｓ Ａ＆Ｍ Ｕｎｉｖｅｒｓｉｔｙ Ｓｙｓｔｅｍ | 医薬組成物の製造方法 |
| WO2011059547A2 (en) | 2009-10-30 | 2011-05-19 | Xenotech, Llc | Cryopreservation of cells and subcellular fractions |
| US8846028B2 (en) | 2010-10-28 | 2014-09-30 | The Invention Science Fund I, Llc | Mitochondrial enhancement of cells |
| EA201490050A1 (ru) | 2011-06-29 | 2014-07-30 | Зе Дженерэл Хоспитэл Корпорейшн | Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток |
| US8648034B2 (en) * | 2011-12-09 | 2014-02-11 | Changhua Christian Hospital | Method and applications of peptide-mediated mitochondrial delivery system |
| WO2013149064A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells |
| WO2013171752A1 (en) | 2012-05-16 | 2013-11-21 | Minovia Therapeutics Ltd. | Compositions and methods for inducing angiogenesis |
| WO2016008937A1 (en) * | 2014-07-16 | 2016-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the intercellular transfer of isolated mitochondria in recipient cells |
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Patent Citations (2)
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|---|---|---|---|---|
| US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
| WO2013035101A1 (en) * | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
Non-Patent Citations (1)
| Title |
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| KITANI, T., ET AL., DIRECT HUMAN MITOCHONDRIAL TRANSFER: A NOVEL CONCEPT BASED ON THE ENDOSYMBIOTIC THEORY., 31 May 2014 (2014-05-31) * |
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