JP7015169B2 - 機能性ミトコンドリアで富化された哺乳動物細胞 - Google Patents
機能性ミトコンドリアで富化された哺乳動物細胞 Download PDFInfo
- Publication number
- JP7015169B2 JP7015169B2 JP2017544332A JP2017544332A JP7015169B2 JP 7015169 B2 JP7015169 B2 JP 7015169B2 JP 2017544332 A JP2017544332 A JP 2017544332A JP 2017544332 A JP2017544332 A JP 2017544332A JP 7015169 B2 JP7015169 B2 JP 7015169B2
- Authority
- JP
- Japan
- Prior art keywords
- bone marrow
- composition
- mitochondrial
- cells
- marrow cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0669—Bone marrow stromal cells; Whole bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021142214A JP7263455B2 (ja) | 2015-02-26 | 2021-09-01 | 機能性ミトコンドリアで富化された哺乳動物細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120907P | 2015-02-26 | 2015-02-26 | |
| US62/120,907 | 2015-02-26 | ||
| PCT/IL2016/050205 WO2016135723A1 (en) | 2015-02-26 | 2016-02-24 | Mammalian cells enriched with functional mitochondria |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142214A Division JP7263455B2 (ja) | 2015-02-26 | 2021-09-01 | 機能性ミトコンドリアで富化された哺乳動物細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507690A JP2018507690A (ja) | 2018-03-22 |
| JP2018507690A5 JP2018507690A5 (enExample) | 2019-04-04 |
| JP7015169B2 true JP7015169B2 (ja) | 2022-02-02 |
Family
ID=56789318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544332A Active JP7015169B2 (ja) | 2015-02-26 | 2016-02-24 | 機能性ミトコンドリアで富化された哺乳動物細胞 |
| JP2021142214A Active JP7263455B2 (ja) | 2015-02-26 | 2021-09-01 | 機能性ミトコンドリアで富化された哺乳動物細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142214A Active JP7263455B2 (ja) | 2015-02-26 | 2021-09-01 | 機能性ミトコンドリアで富化された哺乳動物細胞 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20180030413A1 (enExample) |
| EP (1) | EP3261649A4 (enExample) |
| JP (2) | JP7015169B2 (enExample) |
| IL (2) | IL254071B2 (enExample) |
| WO (1) | WO2016135723A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL282198B2 (en) | 2011-09-11 | 2025-11-01 | Minovia Therapeutics Ltd | Compositions of functional mitochondria and uses thereof |
| CA2952121A1 (en) | 2014-06-13 | 2015-12-17 | Childrens' Medical Center Corporation | Products and methods to isolate mitochondria |
| US20170151287A1 (en) | 2015-11-30 | 2017-06-01 | Flagship Ventures Management, Inc. | Methods and compositions of chondrisomes |
| ES3057779T3 (en) | 2016-01-15 | 2026-03-04 | Childrens Medical Ct Corp | Therapeutic use of mitochondria and combined mitochondrial agents |
| WO2018088874A1 (ko) * | 2016-11-14 | 2018-05-17 | 주식회사 파이안바이오테크놀로지 | 외래 미토콘드리아를 세포로 전달하는 방법 |
| CN109983120A (zh) | 2016-11-14 | 2019-07-05 | 白雁生物技术公司 | 含有外源线粒体的天然杀伤细胞和含有其的药物组合物 |
| CN110022884A (zh) * | 2016-11-30 | 2019-07-16 | 白雁生物技术公司 | 含有线粒体的药物组合物 |
| US20200023005A1 (en) * | 2017-03-26 | 2020-01-23 | Minovia Therapeutics Ltd. | Mitochondrial compositions and methods for treatment of skin and hair |
| WO2019183042A1 (en) * | 2018-03-20 | 2019-09-26 | Unity Biotechnology, Inc. | Autologous mitochondrial extraction and expansion |
| WO2019186553A1 (en) * | 2018-03-27 | 2019-10-03 | Minovia Therapeutics Ltd. | Methods for elevation of lipid and cholesterol metabolism |
| WO2020021541A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria |
| US12502408B2 (en) * | 2018-07-22 | 2025-12-23 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| US12329781B2 (en) | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| JP7524157B2 (ja) * | 2018-07-22 | 2024-07-29 | ミノヴィア セラピューティクス リミテッド | 脳疾患のミトコンドリア増強療法 |
| WO2020021539A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| EP3823644A4 (en) * | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES |
| WO2020021535A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| WO2020021537A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of liver diseases |
| KR20210045435A (ko) * | 2018-08-14 | 2021-04-26 | 이멜 바이오테라퓨틱스, 인코포레이티드. | 미토콘드리아 질환 또는 장애 및 헤테로플라스미를 치료하기 위한 방법 및 조성물 |
| CN112912087A (zh) * | 2018-09-14 | 2021-06-04 | 卢卡科学株式会社 | 线粒体向淋巴器官中的移植以及用于该移植的组合物 |
| JP2022517784A (ja) * | 2019-01-11 | 2022-03-10 | フィジーン、エルエルシー | 線維芽細胞再生細胞 |
| JP7745544B2 (ja) * | 2019-10-24 | 2025-09-29 | イメル バイオセラピューティクス,インク. | ミトコンドリアdna中のマクロヘテロプラスミー及びミクロヘテロプラスミーを検出するための方法 |
| US12091684B2 (en) * | 2020-02-14 | 2024-09-17 | Hackensack Meridian Health, Inc. | Platelet-derived mitochondria treatment and method of generating multipotent cells |
| TWI789723B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療或/及預防腎臟損傷相關疾病之用途 |
| MX2022012157A (es) * | 2020-03-31 | 2023-02-15 | Minovia Therapeutics Ltd | Celulas geneticamente modificadas enriquecidas con mitocondrias y usos de estas. |
| CN115427052A (zh) * | 2020-03-31 | 2022-12-02 | 米诺维亚治疗公司 | 线粒体加强疗法 |
| US20230190822A1 (en) * | 2020-05-05 | 2023-06-22 | Pluri Biotech Ltd. | Methods and compositions for enrichment of target cells |
| AU2023304232A1 (en) * | 2022-07-08 | 2025-01-23 | Mitrix Bio, Inc. | Systems and methods for growing mitochondria and coating thereof |
| EP4598550A1 (en) * | 2022-10-06 | 2025-08-13 | Mitrix Bio, Inc. | Formulations and methods for cellular therapies involving chimeric antigen receptors |
| CN116478920B (zh) * | 2023-05-05 | 2025-03-25 | 重庆理工大学 | 一种离体线粒体的体外储存方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120107285A1 (en) | 2010-10-28 | 2012-05-03 | Searete Llc A Limited Liability Corporation Of The State Of Delaware | Mitochondrial enhancement of cells |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003012050A2 (en) | 2001-07-31 | 2003-02-13 | Northeastern University | Mitochondrial genome replenishment |
| US20050153381A1 (en) * | 2002-02-14 | 2005-07-14 | Marusich Michael F. | Immunocapture of mitochondrial protein complexes |
| AU2004238375A1 (en) | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| US7407800B1 (en) | 2003-09-19 | 2008-08-05 | Pierce Biotechnology, Inc. | Method for the isolation of intact mitochondria from cells |
| CA2688125A1 (en) | 2007-05-02 | 2008-11-13 | The Mclean Hospital Corporation | Methods and compositions for mitochondrial replacement therapy |
| WO2008152640A2 (en) | 2007-06-13 | 2008-12-18 | Pluristem Ltd. | Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells |
| WO2009154770A2 (en) | 2008-06-18 | 2009-12-23 | The Texas A & M University System | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
| US20110105359A1 (en) | 2009-10-30 | 2011-05-05 | Xenotech, Llc | Cryopreservation of cells and subcellular fractions |
| EP2726601B1 (en) | 2011-06-29 | 2018-12-26 | The General Hospital Corporation | Compositions and methods for enhancing bioenergetic status in female germ cells |
| US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
| IL282198B2 (en) * | 2011-09-11 | 2025-11-01 | Minovia Therapeutics Ltd | Compositions of functional mitochondria and uses thereof |
| US8648034B2 (en) * | 2011-12-09 | 2014-02-11 | Changhua Christian Hospital | Method and applications of peptide-mediated mitochondrial delivery system |
| WO2013149064A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells |
| US10702556B2 (en) | 2012-05-16 | 2020-07-07 | Minovia Therpautices Ltd. | Compositions and methods for inducing angiogenesis |
| WO2016008937A1 (en) * | 2014-07-16 | 2016-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the intercellular transfer of isolated mitochondria in recipient cells |
-
2016
- 2016-02-24 US US15/551,600 patent/US20180030413A1/en not_active Abandoned
- 2016-02-24 JP JP2017544332A patent/JP7015169B2/ja active Active
- 2016-02-24 EP EP16754857.7A patent/EP3261649A4/en active Pending
- 2016-02-24 IL IL254071A patent/IL254071B2/en unknown
- 2016-02-24 IL IL299482A patent/IL299482B2/en unknown
- 2016-02-24 WO PCT/IL2016/050205 patent/WO2016135723A1/en not_active Ceased
-
2019
- 2019-06-19 US US16/445,680 patent/US11441124B2/en active Active
-
2020
- 2020-03-24 US US16/828,698 patent/US20200239850A1/en not_active Abandoned
-
2021
- 2021-09-01 JP JP2021142214A patent/JP7263455B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120107285A1 (en) | 2010-10-28 | 2012-05-03 | Searete Llc A Limited Liability Corporation Of The State Of Delaware | Mitochondrial enhancement of cells |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180030413A1 (en) | 2018-02-01 |
| JP2018507690A (ja) | 2018-03-22 |
| JP7263455B2 (ja) | 2023-04-24 |
| US20200239850A1 (en) | 2020-07-30 |
| IL254071B1 (en) | 2023-09-01 |
| IL299482A (en) | 2023-02-01 |
| US11441124B2 (en) | 2022-09-13 |
| EP3261649A4 (en) | 2018-08-15 |
| US20190330595A1 (en) | 2019-10-31 |
| IL299482B2 (en) | 2025-02-01 |
| CA2977341A1 (en) | 2016-09-01 |
| WO2016135723A1 (en) | 2016-09-01 |
| JP2021191776A (ja) | 2021-12-16 |
| IL254071A0 (en) | 2017-10-31 |
| IL299482B1 (en) | 2024-10-01 |
| EP3261649A1 (en) | 2018-01-03 |
| IL254071B2 (en) | 2024-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7263455B2 (ja) | 機能性ミトコンドリアで富化された哺乳動物細胞 | |
| US20240415894A1 (en) | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria | |
| US12502408B2 (en) | Mitochondrial augmentation therapy for primary mitochondrial diseases | |
| US12239672B2 (en) | Mitochondrial augmentation therapy of ocular diseases | |
| US12551504B2 (en) | Mitochondrial augmentation therapy of pancreatic diseases | |
| US20210252075A1 (en) | Mitochondrial augmentation therapy of liver diseases | |
| CA2977341C (en) | Mammalian cells enriched with functional mitochondria |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190220 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190220 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20191120 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191203 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200302 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200915 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201215 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210601 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210901 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220111 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220121 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7015169 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |