IL254071B2 - Mammalian cells are enriched in active mitochondria - Google Patents
Mammalian cells are enriched in active mitochondriaInfo
- Publication number
- IL254071B2 IL254071B2 IL254071A IL25407117A IL254071B2 IL 254071 B2 IL254071 B2 IL 254071B2 IL 254071 A IL254071 A IL 254071A IL 25407117 A IL25407117 A IL 25407117A IL 254071 B2 IL254071 B2 IL 254071B2
- Authority
- IL
- Israel
- Prior art keywords
- bone
- mitochondrial
- cells
- mitochondria
- marrow cells
- Prior art date
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| IL282198B2 (en) | 2011-09-11 | 2025-11-01 | Minovia Therapeutics Ltd | Compositions of functional mitochondria and uses thereof |
| CA2952121A1 (en) | 2014-06-13 | 2015-12-17 | Childrens' Medical Center Corporation | Products and methods to isolate mitochondria |
| US20170151287A1 (en) | 2015-11-30 | 2017-06-01 | Flagship Ventures Management, Inc. | Methods and compositions of chondrisomes |
| ES3057779T3 (en) | 2016-01-15 | 2026-03-04 | Childrens Medical Ct Corp | Therapeutic use of mitochondria and combined mitochondrial agents |
| WO2018088874A1 (ko) * | 2016-11-14 | 2018-05-17 | 주식회사 파이안바이오테크놀로지 | 외래 미토콘드리아를 세포로 전달하는 방법 |
| CN109983120A (zh) | 2016-11-14 | 2019-07-05 | 白雁生物技术公司 | 含有外源线粒体的天然杀伤细胞和含有其的药物组合物 |
| CN110022884A (zh) * | 2016-11-30 | 2019-07-16 | 白雁生物技术公司 | 含有线粒体的药物组合物 |
| US20200023005A1 (en) * | 2017-03-26 | 2020-01-23 | Minovia Therapeutics Ltd. | Mitochondrial compositions and methods for treatment of skin and hair |
| WO2019183042A1 (en) * | 2018-03-20 | 2019-09-26 | Unity Biotechnology, Inc. | Autologous mitochondrial extraction and expansion |
| WO2019186553A1 (en) * | 2018-03-27 | 2019-10-03 | Minovia Therapeutics Ltd. | Methods for elevation of lipid and cholesterol metabolism |
| WO2020021541A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria |
| US12502408B2 (en) * | 2018-07-22 | 2025-12-23 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| US12329781B2 (en) | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| JP7524157B2 (ja) * | 2018-07-22 | 2024-07-29 | ミノヴィア セラピューティクス リミテッド | 脳疾患のミトコンドリア増強療法 |
| WO2020021539A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| EP3823644A4 (en) * | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES |
| WO2020021535A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| WO2020021537A1 (en) * | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of liver diseases |
| KR20210045435A (ko) * | 2018-08-14 | 2021-04-26 | 이멜 바이오테라퓨틱스, 인코포레이티드. | 미토콘드리아 질환 또는 장애 및 헤테로플라스미를 치료하기 위한 방법 및 조성물 |
| CN112912087A (zh) * | 2018-09-14 | 2021-06-04 | 卢卡科学株式会社 | 线粒体向淋巴器官中的移植以及用于该移植的组合物 |
| JP2022517784A (ja) * | 2019-01-11 | 2022-03-10 | フィジーン、エルエルシー | 線維芽細胞再生細胞 |
| JP7745544B2 (ja) * | 2019-10-24 | 2025-09-29 | イメル バイオセラピューティクス，インク． | ミトコンドリアｄｎａ中のマクロヘテロプラスミー及びミクロヘテロプラスミーを検出するための方法 |
| US12091684B2 (en) * | 2020-02-14 | 2024-09-17 | Hackensack Meridian Health, Inc. | Platelet-derived mitochondria treatment and method of generating multipotent cells |
| TWI789723B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療或/及預防腎臟損傷相關疾病之用途 |
| MX2022012157A (es) * | 2020-03-31 | 2023-02-15 | Minovia Therapeutics Ltd | Celulas geneticamente modificadas enriquecidas con mitocondrias y usos de estas. |
| CN115427052A (zh) * | 2020-03-31 | 2022-12-02 | 米诺维亚治疗公司 | 线粒体加强疗法 |
| US20230190822A1 (en) * | 2020-05-05 | 2023-06-22 | Pluri Biotech Ltd. | Methods and compositions for enrichment of target cells |
| AU2023304232A1 (en) * | 2022-07-08 | 2025-01-23 | Mitrix Bio, Inc. | Systems and methods for growing mitochondria and coating thereof |
| EP4598550A1 (en) * | 2022-10-06 | 2025-08-13 | Mitrix Bio, Inc. | Formulations and methods for cellular therapies involving chimeric antigen receptors |
| CN116478920B (zh) * | 2023-05-05 | 2025-03-25 | 重庆理工大学 | 一种离体线粒体的体外储存方法 |
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| WO2013035101A1 (en) * | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
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| WO2003012050A2 (en) | 2001-07-31 | 2003-02-13 | Northeastern University | Mitochondrial genome replenishment |
| US20050153381A1 (en) * | 2002-02-14 | 2005-07-14 | Marusich Michael F. | Immunocapture of mitochondrial protein complexes |
| AU2004238375A1 (en) | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| US7407800B1 (en) | 2003-09-19 | 2008-08-05 | Pierce Biotechnology, Inc. | Method for the isolation of intact mitochondria from cells |
| CA2688125A1 (en) | 2007-05-02 | 2008-11-13 | The Mclean Hospital Corporation | Methods and compositions for mitochondrial replacement therapy |
| WO2008152640A2 (en) | 2007-06-13 | 2008-12-18 | Pluristem Ltd. | Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells |
| WO2009154770A2 (en) | 2008-06-18 | 2009-12-23 | The Texas A & M University System | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
| US20110105359A1 (en) | 2009-10-30 | 2011-05-05 | Xenotech, Llc | Cryopreservation of cells and subcellular fractions |
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| US20130022666A1 (en) * | 2011-07-20 | 2013-01-24 | Anna Brzezinska | Methods and compositions for transfer of mitochondria into mammalian cells |
| WO2013035101A1 (en) * | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
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| IL299482B2 (en) | 2025-02-01 |
| CA2977341A1 (en) | 2016-09-01 |
| WO2016135723A1 (en) | 2016-09-01 |
| JP2021191776A (ja) | 2021-12-16 |
| IL254071A0 (en) | 2017-10-31 |
| IL299482B1 (en) | 2024-10-01 |
| EP3261649A1 (en) | 2018-01-03 |
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