IL298855A - Combined treatment with deoxyuridine triphosphatase inhibitors - Google Patents

Combined treatment with deoxyuridine triphosphatase inhibitors

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Publication number
IL298855A
IL298855A IL298855A IL29885522A IL298855A IL 298855 A IL298855 A IL 298855A IL 298855 A IL298855 A IL 298855A IL 29885522 A IL29885522 A IL 29885522A IL 298855 A IL298855 A IL 298855A
Authority
IL
Israel
Prior art keywords
optionally substituted
substituted
cancer
inhibitor
agent
Prior art date
Application number
IL298855A
Other languages
English (en)
Hebrew (he)
Original Assignee
Cv6 Therapeutics Ni Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv6 Therapeutics Ni Ltd filed Critical Cv6 Therapeutics Ni Ltd
Publication of IL298855A publication Critical patent/IL298855A/en

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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US5962246A (en) 1996-03-29 1999-10-05 The University Of Medicine And Dentistry Of New Jersey dUTPase, its isoforms, and diagnostic and other uses
US8530490B2 (en) 2008-06-03 2013-09-10 Taiho Pharmaceutical Co., Ltd. Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
US20110212467A1 (en) 2008-08-27 2011-09-01 University Of Southern California INHIBITORS OF dUTPase
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US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
PT3319939T (pt) * 2015-07-08 2025-03-05 Cv6 Therapeutics Ni Ltd Inibidores de desoxiuridina-trifosfatase contendo hidantoína
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US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US11168059B2 (en) 2016-11-23 2021-11-09 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
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