IL298399A - Treatment of facial wrinkles with the botulinum toxin in high dose and low volume - Google Patents
Treatment of facial wrinkles with the botulinum toxin in high dose and low volumeInfo
- Publication number
- IL298399A IL298399A IL298399A IL29839922A IL298399A IL 298399 A IL298399 A IL 298399A IL 298399 A IL298399 A IL 298399A IL 29839922 A IL29839922 A IL 29839922A IL 298399 A IL298399 A IL 298399A
- Authority
- IL
- Israel
- Prior art keywords
- botulinum toxin
- lines
- treatment
- dose
- days
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title claims description 110
- 229940053031 botulinum toxin Drugs 0.000 title claims description 96
- 238000011282 treatment Methods 0.000 title claims description 94
- 230000037303 wrinkles Effects 0.000 title claims description 64
- 230000001815 facial effect Effects 0.000 title claims description 54
- 206010040954 Skin wrinkling Diseases 0.000 claims description 144
- 239000007924 injection Substances 0.000 claims description 68
- 238000002347 injection Methods 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 18
- 210000001061 forehead Anatomy 0.000 claims description 15
- 231100001103 botulinum neurotoxin Toxicity 0.000 claims description 14
- 231100000189 neurotoxic Toxicity 0.000 claims description 12
- 230000002887 neurotoxic effect Effects 0.000 claims description 12
- 241000193155 Clostridium botulinum Species 0.000 claims description 8
- 239000007927 intramuscular injection Substances 0.000 claims description 5
- 238000010255 intramuscular injection Methods 0.000 claims description 5
- 235000004252 protein component Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 59
- 210000003205 muscle Anatomy 0.000 description 53
- 108010024001 incobotulinumtoxinA Proteins 0.000 description 34
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 21
- 230000006872 improvement Effects 0.000 description 21
- 230000009471 action Effects 0.000 description 18
- 239000002581 neurotoxin Substances 0.000 description 18
- 231100000618 neurotoxin Toxicity 0.000 description 18
- 101710138657 Neurotoxin Proteins 0.000 description 17
- 239000003053 toxin Substances 0.000 description 17
- 231100000765 toxin Toxicity 0.000 description 17
- 108700012359 toxins Proteins 0.000 description 17
- 230000002411 adverse Effects 0.000 description 13
- 235000018102 proteins Nutrition 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 12
- 102000008100 Human Serum Albumin Human genes 0.000 description 11
- 108091006905 Human Serum Albumin Proteins 0.000 description 11
- 108010079650 abobotulinumtoxinA Proteins 0.000 description 11
- 229940094657 botulinum toxin type a Drugs 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 229940037201 oris Drugs 0.000 description 10
- 230000004044 response Effects 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 8
- 241000225674 Procerus Species 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 231100000673 dose–response relationship Toxicity 0.000 description 7
- 229940018272 xeomin Drugs 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
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- 230000015572 biosynthetic process Effects 0.000 description 5
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- 238000010790 dilution Methods 0.000 description 5
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- 239000000945 filler Substances 0.000 description 5
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- 230000005923 long-lasting effect Effects 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 208000004130 Blepharoptosis Diseases 0.000 description 3
- 206010015995 Eyelid ptosis Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 229940077429 abobotulinumtoxina Drugs 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229940089093 botox Drugs 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 229940098753 dysport Drugs 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 239000000185 hemagglutinin Substances 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 229960004716 idoxuridine Drugs 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 229940077446 onabotulinumtoxina Drugs 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 201000003004 ptosis Diseases 0.000 description 3
- 108010074523 rimabotulinumtoxinB Proteins 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 230000002459 sustained effect Effects 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000000423 cell based assay Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229940124272 protein stabilizer Drugs 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 230000000946 synaptic effect Effects 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 101710117542 Botulinum neurotoxin type A Proteins 0.000 description 1
- 101710082714 Exotoxin A Proteins 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 241000158526 Nasalis Species 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 108010069023 botulinum toxin type E Proteins 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 229940112646 myobloc Drugs 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000008760 nerve sprouting Effects 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000011268 retreatment Methods 0.000 description 1
- 229940077435 rimabotulinumtoxinb Drugs 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007888 toxin activity Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20178574 | 2020-06-05 | ||
| PCT/EP2021/064986 WO2021245223A1 (en) | 2020-06-05 | 2021-06-04 | High dose and low volume botulinum toxin treatment of facial wrinkles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL298399A true IL298399A (en) | 2023-01-01 |
Family
ID=71016459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL298399A IL298399A (en) | 2020-06-05 | 2021-06-04 | Treatment of facial wrinkles with the botulinum toxin in high dose and low volume |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12599550B2 (https=) |
| EP (2) | EP4161562B1 (https=) |
| JP (1) | JP2023529095A (https=) |
| KR (1) | KR20230020961A (https=) |
| CN (1) | CN115666629A (https=) |
| AU (1) | AU2021286196A1 (https=) |
| BR (1) | BR112022023413A2 (https=) |
| CA (1) | CA3177835A1 (https=) |
| ES (1) | ES3013130T3 (https=) |
| IL (1) | IL298399A (https=) |
| MX (1) | MX2022014564A (https=) |
| TW (1) | TW202214211A (https=) |
| WO (1) | WO2021245223A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL298399A (en) | 2020-06-05 | 2023-01-01 | Merz Pharma Gmbh & Co Kgaa | Treatment of facial wrinkles with the botulinum toxin in high dose and low volume |
| KR20240169045A (ko) * | 2022-04-01 | 2024-12-02 | 충칭 클라루비스 파마슈티컬 컴퍼니 리미티드 | 보툴리눔 독소 단백질 조성물, 이의 제조 방법 및 용도 |
| EP4626556A1 (en) * | 2022-11-28 | 2025-10-08 | Merz Pharma GmbH & Co. KGaA | High concentration botulinum toxin treatment for neck rejuvenation |
| WO2025231403A1 (en) * | 2024-05-03 | 2025-11-06 | Revivity Pharma Corporation | Methods of administering and manufacturing toxic compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| BRPI0513850A (pt) | 2004-07-26 | 2008-05-20 | Merz Pharma Gmbh & Co Kgaa | composição terapêutica com uma neurotoxina botulìnica |
| EP2072039A1 (en) * | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
| PL2271670T3 (pl) | 2008-03-14 | 2015-05-29 | Allergan Inc | Testy aktywności serotypu A toksyny botulinowej oparte na immunologii |
| HUE037509T2 (hu) * | 2011-09-29 | 2018-09-28 | Cellsnap Llc | Készítmények és eljárások toxigenicitás meghatározására |
| PL3014267T3 (pl) * | 2013-06-28 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Środki i sposoby określania aktywności biologicznej polipeptydów neurotoksyny w komórkach |
| US9480731B2 (en) * | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| SG11202005239YA (en) * | 2017-12-04 | 2020-07-29 | Revance Therapeutics Inc | Injectable botulinum toxin formulations and methods of use thereof having high response rate and long effect duration |
| IL298399A (en) | 2020-06-05 | 2023-01-01 | Merz Pharma Gmbh & Co Kgaa | Treatment of facial wrinkles with the botulinum toxin in high dose and low volume |
-
2021
- 2021-06-04 IL IL298399A patent/IL298399A/en unknown
- 2021-06-04 US US18/007,712 patent/US12599550B2/en active Active
- 2021-06-04 EP EP21728601.2A patent/EP4161562B1/en active Active
- 2021-06-04 KR KR1020227040449A patent/KR20230020961A/ko active Pending
- 2021-06-04 ES ES21728601T patent/ES3013130T3/es active Active
- 2021-06-04 TW TW110120421A patent/TW202214211A/zh unknown
- 2021-06-04 JP JP2022573504A patent/JP2023529095A/ja active Pending
- 2021-06-04 AU AU2021286196A patent/AU2021286196A1/en active Pending
- 2021-06-04 CA CA3177835A patent/CA3177835A1/en active Pending
- 2021-06-04 CN CN202180037805.1A patent/CN115666629A/zh active Pending
- 2021-06-04 BR BR112022023413A patent/BR112022023413A2/pt unknown
- 2021-06-04 EP EP24206746.0A patent/EP4467202A3/en active Pending
- 2021-06-04 MX MX2022014564A patent/MX2022014564A/es unknown
- 2021-06-04 WO PCT/EP2021/064986 patent/WO2021245223A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023529095A (ja) | 2023-07-07 |
| CN115666629A (zh) | 2023-01-31 |
| EP4161562A1 (en) | 2023-04-12 |
| MX2022014564A (es) | 2022-12-15 |
| EP4467202A3 (en) | 2025-02-19 |
| WO2021245223A1 (en) | 2021-12-09 |
| EP4161562B1 (en) | 2024-11-20 |
| AU2021286196A1 (en) | 2022-12-01 |
| KR20230020961A (ko) | 2023-02-13 |
| EP4467202A2 (en) | 2024-11-27 |
| ES3013130T3 (en) | 2025-04-11 |
| TW202214211A (zh) | 2022-04-16 |
| BR112022023413A2 (pt) | 2022-12-20 |
| CA3177835A1 (en) | 2021-12-09 |
| US20230329996A1 (en) | 2023-10-19 |
| US12599550B2 (en) | 2026-04-14 |
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