IL294369A - Compounds for the treatment of myelofibrosis - Google Patents
Compounds for the treatment of myelofibrosisInfo
- Publication number
- IL294369A IL294369A IL294369A IL29436922A IL294369A IL 294369 A IL294369 A IL 294369A IL 294369 A IL294369 A IL 294369A IL 29436922 A IL29436922 A IL 29436922A IL 294369 A IL294369 A IL 294369A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- patient
- administered
- inhibitor
- Prior art date
Links
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201962953654P | 2019-12-26 | 2019-12-26 | |
| PCT/US2020/066762 WO2021133866A1 (en) | 2019-12-26 | 2020-12-23 | Compounds for the treatment of myelofibrosis |
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| MY191357A (en) * | 2012-11-15 | 2022-06-19 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| AU2014354769A1 (en) * | 2013-11-26 | 2016-05-26 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
| CN106349224A (zh) * | 2016-08-03 | 2017-01-25 | 山东大学 | 一种含有4‑氨基‑(1h)‑吡唑结构的jak激酶抑制剂及其制备方法和应用 |
| WO2019222483A1 (en) * | 2018-05-17 | 2019-11-21 | Board Of Regents, The University Of Texas System | Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form beta inhibitors |
| AU2019280693B2 (en) * | 2018-06-05 | 2024-10-10 | Actuate Therapeutics Inc. | Methods of treating malignant lymphoproliferative disorders |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2023508491A (ja) | 2023-03-02 |
| AU2020415440A1 (en) | 2022-08-04 |
| US20230062278A1 (en) | 2023-03-02 |
| CN115697323A (zh) | 2023-02-03 |
| KR20230005808A (ko) | 2023-01-10 |
| WO2021133866A1 (en) | 2021-07-01 |
| CA3166251A1 (en) | 2021-07-01 |
| EP4081213A1 (en) | 2022-11-02 |
| BR112022012819A2 (pt) | 2022-09-06 |
| MX2022008046A (es) | 2022-11-14 |
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