IL288439A - Compounds and methods for regeneration of the thymus gland and restoration of t cells - Google Patents
Compounds and methods for regeneration of the thymus gland and restoration of t cellsInfo
- Publication number
- IL288439A IL288439A IL288439A IL28843921A IL288439A IL 288439 A IL288439 A IL 288439A IL 288439 A IL288439 A IL 288439A IL 28843921 A IL28843921 A IL 28843921A IL 288439 A IL288439 A IL 288439A
- Authority
- IL
- Israel
- Prior art keywords
- compositions
- methods
- cell reconstitution
- thymic regeneration
- thymic
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
- 230000002992 thymic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962853452P | 2019-05-28 | 2019-05-28 | |
| PCT/US2020/034932 WO2020243310A1 (en) | 2019-05-28 | 2020-05-28 | Compositions and methods for thymic regeneration and t-cell reconstitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL288439A true IL288439A (en) | 2022-01-01 |
Family
ID=73553922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL288439A IL288439A (en) | 2019-05-28 | 2021-11-25 | Compounds and methods for regeneration of the thymus gland and restoration of t cells |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220226391A1 (https=) |
| EP (1) | EP3976065A4 (https=) |
| JP (1) | JP7637418B2 (https=) |
| KR (1) | KR20220015451A (https=) |
| CN (1) | CN114340642A (https=) |
| AU (1) | AU2020283586A1 (https=) |
| CA (1) | CA3141989A1 (https=) |
| IL (1) | IL288439A (https=) |
| SG (1) | SG11202113119QA (https=) |
| WO (1) | WO2020243310A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2753441C2 (ru) | 2016-09-13 | 2021-08-16 | Ангиокрин Биосайенс, Инк. | Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки |
| WO2024155791A1 (en) * | 2023-01-18 | 2024-07-25 | Angiocrine Bioscience, Inc. | Use of umbilical vein endothelial cells for the treatment of lung injury |
| WO2025245461A1 (en) * | 2024-05-23 | 2025-11-27 | Thymofox Inc. | Methods of activating foxn1 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8465732B2 (en) * | 2007-01-19 | 2013-06-18 | Cornell Research Foundation, Inc. | Endothelial cells expressing adenovirus E4ORF1 and methods of use thereof |
| WO2016069911A1 (en) * | 2014-10-29 | 2016-05-06 | Jarrod Dudakov | Use of bmp4 for thymic regeneration |
| RU2743761C2 (ru) | 2014-12-19 | 2021-02-25 | Анджиокрин Биосайенс, Инк. | Биосовместимые имплантаты, содержащие сконструированные эндотелиальные клетки |
| RU2753441C2 (ru) * | 2016-09-13 | 2021-08-16 | Ангиокрин Биосайенс, Инк. | Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки |
-
2020
- 2020-05-28 KR KR1020217042865A patent/KR20220015451A/ko not_active Ceased
- 2020-05-28 CN CN202080053410.6A patent/CN114340642A/zh active Pending
- 2020-05-28 SG SG11202113119QA patent/SG11202113119QA/en unknown
- 2020-05-28 WO PCT/US2020/034932 patent/WO2020243310A1/en not_active Ceased
- 2020-05-28 CA CA3141989A patent/CA3141989A1/en active Pending
- 2020-05-28 US US17/614,521 patent/US20220226391A1/en active Pending
- 2020-05-28 AU AU2020283586A patent/AU2020283586A1/en not_active Abandoned
- 2020-05-28 JP JP2021570514A patent/JP7637418B2/ja active Active
- 2020-05-28 EP EP20813769.5A patent/EP3976065A4/en not_active Withdrawn
-
2021
- 2021-11-25 IL IL288439A patent/IL288439A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3976065A1 (en) | 2022-04-06 |
| JP7637418B2 (ja) | 2025-02-28 |
| US20220226391A1 (en) | 2022-07-21 |
| KR20220015451A (ko) | 2022-02-08 |
| AU2020283586A1 (en) | 2021-12-23 |
| CA3141989A1 (en) | 2020-12-03 |
| JP2022534586A (ja) | 2022-08-02 |
| SG11202113119QA (en) | 2021-12-30 |
| CN114340642A (zh) | 2022-04-12 |
| WO2020243310A1 (en) | 2020-12-03 |
| EP3976065A4 (en) | 2023-05-03 |
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