CN114340642A - 用于胸腺再生和t细胞重建的组合物和方法 - Google Patents

用于胸腺再生和t细胞重建的组合物和方法 Download PDF

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Publication number
CN114340642A
CN114340642A CN202080053410.6A CN202080053410A CN114340642A CN 114340642 A CN114340642 A CN 114340642A CN 202080053410 A CN202080053410 A CN 202080053410A CN 114340642 A CN114340642 A CN 114340642A
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cells
ntec
subject
e4orf1
ntecs
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CN202080053410.6A
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English (en)
Chinese (zh)
Inventor
P·W·芬尼根
D·J·诺兰
K·库哈若娃
M·D·金斯伯格
K·N·威尔斯
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Angiocrine Bioscience Inc
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Angiocrine Bioscience Inc
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Publication of CN114340642A publication Critical patent/CN114340642A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080053410.6A 2019-05-28 2020-05-28 用于胸腺再生和t细胞重建的组合物和方法 Pending CN114340642A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962853452P 2019-05-28 2019-05-28
US62/853,452 2019-05-28
PCT/US2020/034932 WO2020243310A1 (en) 2019-05-28 2020-05-28 Compositions and methods for thymic regeneration and t-cell reconstitution

Publications (1)

Publication Number Publication Date
CN114340642A true CN114340642A (zh) 2022-04-12

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ID=73553922

Family Applications (1)

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CN202080053410.6A Pending CN114340642A (zh) 2019-05-28 2020-05-28 用于胸腺再生和t细胞重建的组合物和方法

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Country Link
US (1) US20220226391A1 (https=)
EP (1) EP3976065A4 (https=)
JP (1) JP7637418B2 (https=)
KR (1) KR20220015451A (https=)
CN (1) CN114340642A (https=)
AU (1) AU2020283586A1 (https=)
CA (1) CA3141989A1 (https=)
IL (1) IL288439A (https=)
SG (1) SG11202113119QA (https=)
WO (1) WO2020243310A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2753441C2 (ru) 2016-09-13 2021-08-16 Ангиокрин Биосайенс, Инк. Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки
WO2024155791A1 (en) * 2023-01-18 2024-07-25 Angiocrine Bioscience, Inc. Use of umbilical vein endothelial cells for the treatment of lung injury
WO2025245461A1 (en) * 2024-05-23 2025-11-27 Thymofox Inc. Methods of activating foxn1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093081A1 (en) * 2007-01-19 2010-04-15 Cornell Research Foundation, Inc. Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis
US20170292111A1 (en) * 2014-10-29 2017-10-12 Memorial Sloan-Kettering Cancer Center Use of bmp4 for thymic regeneration
WO2018052948A1 (en) * 2016-09-13 2018-03-22 Angiocrine Bioscience, Inc. Blood-brain barrier comprising engineered endothelial cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2743761C2 (ru) 2014-12-19 2021-02-25 Анджиокрин Биосайенс, Инк. Биосовместимые имплантаты, содержащие сконструированные эндотелиальные клетки

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093081A1 (en) * 2007-01-19 2010-04-15 Cornell Research Foundation, Inc. Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis
US20170292111A1 (en) * 2014-10-29 2017-10-12 Memorial Sloan-Kettering Cancer Center Use of bmp4 for thymic regeneration
WO2018052948A1 (en) * 2016-09-13 2018-03-22 Angiocrine Bioscience, Inc. Blood-brain barrier comprising engineered endothelial cells

Also Published As

Publication number Publication date
EP3976065A1 (en) 2022-04-06
JP7637418B2 (ja) 2025-02-28
US20220226391A1 (en) 2022-07-21
IL288439A (en) 2022-01-01
KR20220015451A (ko) 2022-02-08
AU2020283586A1 (en) 2021-12-23
CA3141989A1 (en) 2020-12-03
JP2022534586A (ja) 2022-08-02
SG11202113119QA (en) 2021-12-30
WO2020243310A1 (en) 2020-12-03
EP3976065A4 (en) 2023-05-03

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