IL287199A - ייצור פפטידים קשורים דיסולפידים - Google Patents
ייצור פפטידים קשורים דיסולפידיםInfo
- Publication number
- IL287199A IL287199A IL287199A IL28719921A IL287199A IL 287199 A IL287199 A IL 287199A IL 287199 A IL287199 A IL 287199A IL 28719921 A IL28719921 A IL 28719921A IL 287199 A IL287199 A IL 287199A
- Authority
- IL
- Israel
- Prior art keywords
- disulfide
- production
- linked peptides
- peptides
- linked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0033—Optimalisation processes, i.e. processes with adaptive control systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00164—Controlling or regulating processes controlling the flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00186—Controlling or regulating processes controlling the composition of the reactive mixture
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Water Supply & Treatment (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Automation & Control Theory (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19169656 | 2019-04-16 | ||
| PCT/EP2020/060691 WO2020212477A1 (en) | 2019-04-16 | 2020-04-16 | Manufacture of disulfide bonded peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL287199A true IL287199A (he) | 2021-12-01 |
Family
ID=66290199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL287199A IL287199A (he) | 2019-04-16 | 2021-10-12 | ייצור פפטידים קשורים דיסולפידים |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12466851B2 (he) |
| EP (1) | EP3956343A1 (he) |
| JP (1) | JP7770923B2 (he) |
| CN (1) | CN114026107A (he) |
| IL (1) | IL287199A (he) |
| WO (1) | WO2020212477A1 (he) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112679574B (zh) * | 2020-11-16 | 2023-01-17 | 北京大学深圳研究生院 | 一种基于青霉胺的多肽二硫键合成方法及其应用 |
| WO2025229200A1 (en) | 2024-05-03 | 2025-11-06 | Bachem Holding Ag | Manufacture of disulfide bonded peptides |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4216141A (en) | 1978-07-19 | 1980-08-05 | The Salk Institute For Biological Studies | Method for cyclization of peptides |
| JPS60243021A (ja) * | 1984-03-28 | 1985-12-03 | シタス コ−ポレイシヨン | システイン含有蛋白質の制御された酸化方法 |
| US4530787A (en) | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| HU206890B (en) | 1986-10-13 | 1993-01-28 | Sandoz Ag | Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components |
| AT398766B (de) | 1988-05-26 | 1995-01-25 | Gebro Broschek Gmbh | Verfahren zur intramolekularen oxidation von zwei -sh gruppen in einer peptidverbindung zu einer disulfidbrücke |
| PT710243E (pt) * | 1993-06-29 | 2000-11-30 | Ferring Bv | Sintese melhorada de peptidos ciclicos. |
| US6548276B2 (en) * | 2000-09-06 | 2003-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced in vitro synthesis of active proteins containing disulfide bonds |
| ITMI20040812A1 (it) | 2004-04-26 | 2004-07-26 | Chemi Spa | Processo per la formazione di legami disofluro in peptidi ciclici |
| JP5537820B2 (ja) | 2009-03-13 | 2014-07-02 | 株式会社村田製作所 | 化合物にジスルフィド結合を形成させる方法 |
| WO2011098095A1 (en) * | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
| EP3674320A3 (en) | 2011-10-27 | 2020-08-12 | Genmab A/S | Production of heterodimeric proteins |
| CN104245096B (zh) | 2012-04-20 | 2017-05-24 | 佛兰芒技术研究所有限公司 | 具有膜分离步骤的改进的稀释的化学反应方法 |
| JP6289937B2 (ja) | 2014-02-27 | 2018-03-07 | 学校法人東海大学 | リラキシンの製造方法 |
| SG11201701878TA (en) | 2014-09-17 | 2017-04-27 | Vito Nv | Reaction process with membrane separation |
| US10690635B2 (en) | 2016-03-23 | 2020-06-23 | Bachem Holding Ag | Purification of glucagon-like peptide 1 analogs |
| EP3454890A4 (en) * | 2016-05-10 | 2020-01-15 | MedImmune, LLC | PREVENTION OF PROTEIN DISULFIDE BOND REDUCTION |
| CN207596761U (zh) | 2018-03-27 | 2018-07-10 | 润辉生物技术（威海）有限公司 | 一种可控温的自动加液多肽合成装置 |
-
2020
- 2020-04-16 US US17/603,826 patent/US12466851B2/en active Active
- 2020-04-16 JP JP2021561655A patent/JP7770923B2/ja active Active
- 2020-04-16 EP EP20717696.7A patent/EP3956343A1/en active Pending
- 2020-04-16 WO PCT/EP2020/060691 patent/WO2020212477A1/en not_active Ceased
- 2020-04-16 CN CN202080043908.4A patent/CN114026107A/zh active Pending
-
2021
- 2021-10-12 IL IL287199A patent/IL287199A/he unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7770923B2 (ja) | 2025-11-17 |
| CN114026107A (zh) | 2022-02-08 |
| WO2020212477A1 (en) | 2020-10-22 |
| EP3956343A1 (en) | 2022-02-23 |
| JP2022529774A (ja) | 2022-06-24 |
| US12466851B2 (en) | 2025-11-11 |
| US20220213139A1 (en) | 2022-07-07 |
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